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Indications & Uses
T-Dex is used for steroid-responsive inflammatory conditions of the eye (affecting the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe) where a superficial bacterial eye infection is also present. It is also used for chronic anterior uveitis and for corneal injury caused by chemical, radiation or thermal burns, or by penetrating foreign bodies. A combination product containing an anti-infective component is appropriate when the risk of superficial eye infection is high.
Pharmacology
Like other aminoglycosides, Tobramycin exerts its bactericidal effect by specifically blocking normal protein synthesis in susceptible bacteria, although the exact mechanism is still not fully understood. It is believed that this inhibition occurs through an action on the ribosome, causing bacteria to misread messenger RNA. Dexamethasone, for its part, works by inhibiting phospholipase A2, the first step in prostaglandin synthesis, and also suppresses the chemotactic infiltration of neutrophils into the site of inflammation. As a result, its anti-inflammatory activity is about 25 times greater, and its overall therapeutic effectiveness 8 to 10 times greater, than that of hydrocortisone.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Apply a small amount into the conjunctival sac 3 to 4 times a day. Close the eyes slowly without blinking and keep them closed for 1 to 2 minutes.
Pediatric Use: Safety and effectiveness in pediatric patients under 2 years of age have not been established.
Dosage for other forms (1)
Place 1 drop into the conjunctival sac 3 to 5 times a day. During the first 24 to 48 hours, the dose may be raised to 1 drop every 2 hours.
Side Effects
Tobramycin, the antibiotic in this combination, most often causes hypersensitivity and local irritation of the eye, such as itching and swelling of the eyelids and redness of the conjunctiva. These reactions affect fewer than 4% of patients. The steroid component (Dexamethasone) may cause a rise in pressure inside the eye, which can lead to glaucoma and, rarely, damage to the optic nerve. It may also cause a posterior subcapsular cataract to form and may delay wound healing.
Cautions & Contraindications
Warnings & Precautions
Fungal infection of the cornea is a possibility to keep in mind after long-term steroid use. As with other antibiotic preparations, prolonged use may lead to overgrowth of organisms that are not susceptible to the drug, including fungi. If a superinfection develops, appropriate treatment should be started. Cross-sensitivity to other aminoglycoside antibiotics can occur; if hypersensitivity develops while using this product, stop treatment and begin appropriate therapy.
Contraindications
This combination must not be used in patients with epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, or many other viral diseases of the cornea and conjunctiva. It is also contraindicated in mycobacterial infection of the eye, and in anyone with hypersensitivity to any component of the medication.
Pregnancy & Breastfeeding
Pregnancy: Well-controlled studies in pregnant women have not been conducted. This ophthalmic solution should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Nursing Mothers: It is not known whether topical corticosteroids are absorbed into the bloodstream in amounts sufficient to appear in human breast milk. Because many drugs do pass into human milk, nursing mothers should use caution if this ophthalmic solution is prescribed for them.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Overdose from local use of Dexamethasone + Tobramycin is not known. If someone swallows it by accident, take specific measures to reduce absorption. There is no specific antidote.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Dexamethasone + Tobramycin at room temperature. Close the bottle straight after each use. Once you've opened the bottle, don't use the contents for longer than one month.
Common questions about Orbidex T 0.1%+0.3%
What is Orbidex T 0.1%+0.3% Ophthalmic Ointment?
Orbidex T 0.1%+0.3% Ophthalmic Ointment is a medicine that contains Dexamethasone + Tobramycin. It is made by Popular Pharmaceuticals PLC. It belongs to the Aminoglycosides group of medicines.
What is Orbidex T used for?
T-Dex is used for steroid-responsive inflammatory conditions of the eye (affecting the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe) where a superficial bacterial eye infection is also present. It is also used for chronic anterior uveitis and for corneal injury caused by chemical, radiation or thermal burns, or by penetrating foreign bodies.
What are the side effects of Orbidex T?
Tobramycin, the antibiotic in this combination, most often causes hypersensitivity and local irritation of the eye, such as itching and swelling of the eyelids and redness of the conjunctiva. These reactions affect fewer than 4% of patients.
Can I take Orbidex T during pregnancy or while breastfeeding?
Pregnancy: Well-controlled studies in pregnant women have not been conducted. This ophthalmic solution should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Orbidex T?
Overdose from local use of Dexamethasone + Tobramycin is not known. If someone swallows it by accident, take specific measures to reduce absorption. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Orbidex T?
Keep Dexamethasone + Tobramycin at room temperature. Close the bottle straight after each use.
Do I need a prescription for Orbidex T?
Orbidex T is a prescription (Rx) medicine. Take it as your doctor advises.