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Same active ingredient — pay up to 38% less
These brands contain the same active ingredient (Gemifloxacin). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Gemifloxacin (Flogem) is used to treat the following bacterial infections in adults, when sensitive organisms cause them. The first is acute bacterial exacerbation of chronic bronchitis, caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae or Moraxella catarrhalis. The second is community-acquired pneumonia of mild to moderate severity, caused by Streptococcus pneumoniae (including multi-drug resistant strains), Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydia pneumoniae or Klebsiella pneumoniae.
Pharmacology
Gemifloxacin is a fluoroquinolone antibiotic and it kills bacteria (it is bactericidal, with minimum bactericidal concentrations). It stops bacteria from making DNA by blocking the bacterial type II topoisomerases, DNA gyrase and/or topoisomerase IV (TOPO IV). Bacteria need both of these enzymes to grow.
After a dose by mouth, gemifloxacin is absorbed quickly and spreads widely through the body. Studies in healthy subjects showed that it reaches target tissues and body fluids rapidly, including the lung (epithelial lining fluid, alveolar macrophages, bronchial tissue) and nasal secretions. About 36% of an oral dose is passed out in the urine and 61% in the feces, as unchanged drug and metabolites.
AUC values were generally only slightly higher (approx. 10%) in women than in men. No dose adjustment is required based on gender.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Acute bacterial exacerbation of chronic bronchitis: the adult dose of gemifloxacin is 320 mg once daily for 5 days.
Community-acquired pneumonia (mild to moderate severity): when the infection is known or suspected to be due to S. pneumoniae, H. influenzae, M. pneumoniae or C. pneumoniae, give one 320 mg tablet daily for 5 days. When it is known or suspected to be due to multi-drug resistant Streptococcus pneumoniae, K. pneumoniae or M. catarrhalis, give one 320 mg tablet daily for 7 days.
Side Effects
The most common side effects with gemifloxacin are abdominal pain, diarrhea, headache, nausea, rash and vomiting. Some others have been reported only rarely. These include fungal overgrowth in the body, dizziness, insomnia, urticaria, pruritis, and a maculopapular erythmatous skin rash.
Cautions & Contraindications
Warnings & Precautions
People with severe kidney impairment need their Gemifloxacin dose changed to 160 mg once daily. Patients on Gemifloxacin should drink enough fluid, because this prevents highly concentrated urine and crystalluria. The medicine may cause dizziness. If that happens, the patient should not drive or operate machinery, or take part in activities that need mental alertness or co-ordination. Tendinitis and tendon rupture can occur at any age during treatment with quinolones, Gemifloxacin included. The risk is higher in elderly patients and when corticosteroids are given at the same time. If tendinitis is suspected, or at the first sign of pain or inflammation, stop Gemifloxacin and rest the affected limb. In clinical studies, Gemifloxacin caused a small mean increase in QTc interval. Use it with caution in patients who are predisposed to QTc interval prolongation, or who are taking other medicines known to prolong the QTc interval. Use it with caution in patients with epilepsy too.
Contraindications
Gemifloxacin should not be given to anyone with a known hypersensitivity to gemifloxacin or to other quinolones. It is also not suitable for patients who have had tendon damage with fluoroquinolones in the past. Children under 18 years of age should not take gemifloxacin.
Pregnancy & Breastfeeding
Pregnant or breastfeeding women should not use Gemifloxacin. Its safety and how well it works have not been established in women who are pregnant or lactating.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Renal impairment: with Gemifloxacin, patients with mild or moderate renal impairment don't need a dose adjustment. Some change in dosage is recommended for patients with severe renal dysfunction. As a guide, when creatinine clearance is above 40 ml/min, the usual dosage applies. When creatinine clearance is below 40 ml/min, the dose is 160 mg once daily. Patients on haemodialysis or continuous ambulatory peritoneal dialysis should also receive 160 mg once daily.
Hepatic impairment: Gemifloxacin may be given to patients with hepatic impairment, and no dose adjustment is required.
Elderly patients: no dose adjustment is required.
Overdose
No specific antidote is known for Gemif. Dialysis doesn't remove enough of the medicine to be useful in an overdose. If someone has taken too much by mouth in a single acute dose, the stomach should be emptied, either by inducing vomiting or by gastric lavage. The patient should then be watched carefully and treated for whatever symptoms appear, and adequate hydration should be maintained.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Gemifloxacin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Orasquin 320 mg
What is Orasquin 320 mg Tablet?
Orasquin 320 mg Tablet is a medicine that contains Gemifloxacin. It is made by Incepta Pharmaceuticals Ltd. It belongs to the 4-Quinolone preparations group of medicines.
What is Orasquin used for?
Gemifloxacin (Flogem) is used to treat the following bacterial infections in adults, when sensitive organisms cause them. The first is acute bacterial exacerbation of chronic bronchitis, caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae or Moraxella catarrhalis.
What are the side effects of Orasquin?
The most common side effects with gemifloxacin are abdominal pain, diarrhea, headache, nausea, rash and vomiting. Some others have been reported only rarely.
Can I take Orasquin during pregnancy or while breastfeeding?
Pregnant or breastfeeding women should not use Gemifloxacin. Its safety and how well it works have not been established in women who are pregnant or lactating. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Orasquin?
No specific antidote is known for Gemif. Dialysis doesn't remove enough of the medicine to be useful in an overdose. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Orasquin?
Store Gemifloxacin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Orasquin?
Some medicines can interact with Gemifloxacin, for example: Sucralfate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Gemitab by Ibn Sina Pharmaceutical Ind. Ltd. has the same ingredient and strength for ৳40.00 per unit, compared with ৳65.00 for Orasquin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Orasquin?
Orasquin is a prescription (Rx) medicine. Take it as your doctor advises.