Olonase
Rx25 mcg+600 mcg • Nasal Spray
Indications & Uses
Olonase is indicated for:
Pharmacology
This is a metered-dose manual nasal spray containing an aqueous suspension of a fixed-dose combination of olopatadine hydrochloride and mometasone furoate monohydrate.
Olopatadine is a histamine-1 (H1) receptor inhibitor. Its antihistamine activity has been documented in isolated tissues, animal models and humans.
Mometasone furoate is a corticosteroid with potent anti-inflammatory activity. The precise way corticosteroids act in allergic rhinitis is not known. They have been shown to have a wide range of inhibitory effects on many cell types (for example mast cells, eosinophils, neutrophils, macrophages and lymphocytes) and on mediators involved in inflammation (for example histamine, eicosanoids, leukotrienes and cytokines).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and adolescents (12 years of age and older): the recommended dose of Mometasone Furoate + Olopatadine Hydrochloride is 2 sprays in each nostril twice daily.
Children (6 to 11 years of age): the recommended dose is 1 spray in each nostril twice daily.
This medicine is for nasal use only. Shake the bottle well before each use, and avoid spraying into the eyes or mouth. See the illustrated patient's instructions for proper use of the nasal spray. Read the complete instructions carefully and use the spray only as directed.
Side Effects
The most common side effects of Mometasone Furoate + Olopatadine Hydrochloride are dysgeusia (an altered sense of taste), epistaxis (nosebleed) and nasal discomfort. Other clinically significant adverse reactions have also been described: local nasal adverse reactions, somnolence and impaired mental alertness, glaucoma and cataracts, hypersensitivity reactions, immunosuppression and risk of infections, and hypercorticism and adrenal suppression.
Cautions & Contraindications
Warnings & Precautions
Epistaxis, nasal ulcerations, nasal septal perforations, impaired wound healing, and Candida albicans infection: patients using this Mometasone Furoate + Olopatadine Hydrochloride nasal spray should be checked from time to time for signs of adverse reactions on the nasal mucosa. Somnolence: don't take on hazardous work that needs complete mental alertness and motor coordination, such as driving or operating machinery, while using this nasal spray. Avoid alcohol or other central nervous system (CNS) depressants with the spray too, because alertness may fall further and CNS performance may be more impaired. Glaucoma and cataracts: monitor patients who have a change in vision or a history of increased intraocular pressure, glaucoma, and/or cataracts. Hypersensitivity reactions can occur with this nasal spray, and reactions including wheezing have occurred after nasal use of mometasone furoate. Stop the spray if such reactions occur. Immunosuppression and risk of infections: there is potential worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or ocular herpes simplex. Chickenpox or measles may also take a more serious or even fatal course in susceptible patients. Use caution in patients with any of these, because of the potential for worsening of these infections. Hypercorticism and adrenal suppression can occur with misuse or use of higher-than-recommended dosages, or even at the regular dosage in susceptible patients at risk for such effects. Potential reduction in growth velocity in children: routinely monitor the growth of pediatric patients receiving this nasal spray.
Contraindications
Don't use Olopatadine Hydrochloride and Mometasone Furoate Nasal Spray if you are allergic to any of its components.
Pregnancy & Breastfeeding
We don't have any data on the use of mometasone furoate in pregnant women, so it isn't known whether it carries a risk of major birth defects, miscarriage or other harmful outcomes for the mother or the baby. There are also no data on whether olopatadine or mometasone furoate, or its metabolites, pass into human milk. The effects on a breastfed child and on milk production are likewise unknown. Other corticosteroids similar to mometasone furoate are excreted in human milk. However, plasma concentrations of mometasone furoate after nasal therapeutic doses are low, so the concentrations in breast milk are likely to be correspondingly low.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Olopatadine Hydrochloride: an overdose of this antihistamine may cause drowsiness in adults and children. In children, agitation and restlessness can come first, followed by drowsiness. If an overdose happens, symptomatic or supportive treatment is recommended.
Mometasone Furoate: long-term overdose with any corticosteroid may lead to signs or symptoms of hypercorticism.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Mometasone Furoate + Olopatadine Hydrochloride below 25°C and don't refrigerate it. Keep it away from light and damp places, and out of reach of children.
Drug Interactions
Common questions about Olonase 25 mcg+600 mcg
What is Olonase 25 mcg+600 mcg Nasal Spray?
Olonase 25 mcg+600 mcg Nasal Spray is a medicine that contains Mometasone Furoate + Olopatadine Hydrochloride. It is made by Eskayef Pharmaceuticals Ltd.
What is Olonase used for?
Olonase is used for: Allergic Rhinitis.
What are the side effects of Olonase?
The most common side effects of Mometasone Furoate + Olopatadine Hydrochloride are dysgeusia (an altered sense of taste), epistaxis (nosebleed) and nasal discomfort. Other clinically significant adverse reactions have also been described: local nasal adverse reactions, somnolence and impaired mental alertness, glaucoma and cataracts, hypersensitivity reactions, immunosuppression and risk of infections, and hypercorticism and adrenal suppression.
Can I take Olonase during pregnancy or while breastfeeding?
We don't have any data on the use of mometasone furoate in pregnant women, so it isn't known whether it carries a risk of major birth defects, miscarriage or other harmful outcomes for the mother or the baby. There are also no data on whether olopatadine or mometasone furoate, or its metabolites, pass into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Olonase?
Olopatadine Hydrochloride: an overdose of this antihistamine may cause drowsiness in adults and children. In children, agitation and restlessness can come first, followed by drowsiness. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Olonase?
Store Mometasone Furoate + Olopatadine Hydrochloride below 25°C and don't refrigerate it. Keep it away from light and damp places, and out of reach of children.
Can I take other medicines with Olonase?
Some medicines can interact with Mometasone Furoate + Olopatadine Hydrochloride, for example: Mometasone Furoate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Olonase?
Olonase is a prescription (Rx) medicine. Take it as your doctor advises.