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Same active ingredient — pay up to 43% less
These brands contain the same active ingredient (Olmesartan Medoxomil). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Olmelo
Other strengths and forms by Naafco Pharma PLC.
Indications & Uses
Olmelo is indicated for:
Pharmacology
Angiotensin II, the main pressor hormone of the renin-angiotensin system, is produced from angiotensin I through the action of angiotensin-converting enzyme (ACE, also known as kininase II). It acts on blood vessels to cause constriction, prompts the adrenal glands to synthesize and release aldosterone, stimulates the heart, and promotes sodium reabsorption by the kidneys.
Olmesartan works by selectively blocking angiotensin II from binding to the AT1 receptor found in vascular smooth muscle, thereby preventing its vessel-constricting effect. A second receptor type, AT2, is also present in many tissues, but it has no established role in cardiovascular regulation. Olmesartan's affinity for the AT1 receptor is more than 12,500 times greater than for the AT2 receptor, making its action highly selective.
Unlike ACE inhibitors, olmesartan medoxomil does not inhibit ACE (kininase II) and therefore does not alter the body's response to bradykinin. By blocking the angiotensin II receptor, olmesartan interrupts the normal feedback mechanism through which angiotensin II suppresses renin release. This leads to a rise in plasma renin activity and circulating angiotensin II levels, but this compensatory increase is not enough to overcome olmesartan's blood-pressure-lowering effect.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual starting dose of olmesartan is 20 mg once daily when it is used on its own, in people who are not volume-depleted. Doses are set individually, so your doctor may choose differently for you. If blood pressure still needs lowering after 2 weeks, the dose can be raised to 40 mg. Going above 40 mg does not seem to lower blood pressure any further. Taking the same total dose in two parts a day gives no advantage over taking it once daily.
No starting dose change is recommended for elderly people, or for people with moderate to marked kidney impairment (creatinine clearance below 40 ml/min) or moderate to marked liver dysfunction. If there is a chance the body has lost fluid from the blood vessels, for example in people taking diuretics, especially those with weaker kidney function, olmesartan should be started under close medical supervision. A lower starting dose may be considered in these cases.
Olmesartan can be taken with or without food.
Paediatric use: Safety and effectiveness in paediatric patients have not been established.
Side Effects
Oltan's safety was assessed in more than 3825 patients and subjects, including more than 3275 patients treated for hypertension in controlled trials. Treatment with Oltan was well tolerated, and the rate of adverse reactions was similar to placebo. The frequency of adverse reactions did not vary by dose. Looking at gender, age and race groups, no differences turned up between patients treated with Oltan and those given placebo. Across all hypertension trials, 2.4% of patients treated with Oltan withdrew due to adverse reactions, compared with 2.7% of control patients. In placebo controlled trials, the only adverse reaction affecting more than 1% of patients treated with Oltan, at a higher rate than placebo, was dizziness (3% vs. 1%). The following adverse reactions occurred in placebo controlled clinical trials in more than 1% of patients treated with Oltan, but at a similar or greater rate among patients given placebo: back pain, bronchitis, increased creatine phosphokinase, diarrhea, headache, hematuria, hyperglycemia, hypertriglyceridemia, influenza like symptoms, pharyngitis, rhinitis and sinusitis. Cough occurred at a similar rate in placebo treated patients (0.7%) and Oltan treated patients (0.9%).
Cautions & Contraindications
Warnings & Precautions
As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals treated with Oltan. In patients whose renal function may depend upon the activity of the renin-angiotensin-aldosterone system (for example, patients with severe congestive heart failure), treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotemia and, rarely, with acute renal failure and/or death. Similar results may be anticipated in patients treated with Oltan.
Contraindications
Olmesartan medoxomil should not be used by anyone who has previously had an allergic reaction to it or to any other ingredient in this medicine.
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding
If pregnancy is confirmed, this medicine should be stopped as soon as possible. Taking a drug that acts directly on the renin-angiotensin system during the second or third trimester of pregnancy can harm the developing baby, and in some cases has led to fetal death. Whether Olmesartan passes into human breast milk is not known, though it has been found at low levels in the milk of nursing rats. Because of the possible risk to a nursing infant, a decision should be made to stop either breastfeeding or the medicine, weighing how important the drug is for the mother's health.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no known experience of overdose with Olmesartan Medoxomil. If it did happen, the most likely effects would be low blood pressure (hypotension) and a fast heart rate (tachycardia). A slow heart rate (bradycardia) could also occur if parasympathetic (vagal) stimulation took place.
If the person has taken the medicine only recently, gastric lavage or induction of emesis may be considered. When an Olmesartan Medoxomil overdose causes clinically significant hypotension, the cardiovascular system needs active support. This means close monitoring of heart and lung function, raising the extremities, and attention to circulating fluid volume and urine output.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Olmesartan Medoxomil in a cool, dry place below 30ºC. Protect it from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Olmelo 40 mg
What is Olmelo 40 mg Tablet?
Olmelo 40 mg Tablet is a medicine that contains Olmesartan Medoxomil. It is made by Naafco Pharma PLC. It belongs to the Angiotensin-ll receptor blocker group of medicines.
What is Olmelo used for?
Olmelo is used for: Hypertension.
What are the side effects of Olmelo?
Oltan's safety was assessed in more than 3825 patients and subjects, including more than 3275 patients treated for hypertension in controlled trials. Treatment with Oltan was well tolerated, and the rate of adverse reactions was similar to placebo.
Can I take Olmelo during pregnancy or while breastfeeding?
Pregnancy & Breastfeeding If pregnancy is confirmed, this medicine should be stopped as soon as possible. Taking a drug that acts directly on the renin-angiotensin system during the second or third trimester of pregnancy can harm the developing baby, and in some cases has led to fetal death. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Olmelo?
There is no known experience of overdose with Olmesartan Medoxomil. If it did happen, the most likely effects would be low blood pressure (hypotension) and a fast heart rate (tachycardia). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Olmelo?
Store Olmesartan Medoxomil in a cool, dry place below 30ºC. Protect it from light and moisture.
Can I take other medicines with Olmelo?
Some medicines can interact with Olmesartan Medoxomil, for example: Digoxin, Olmesartan Medoxomil + Hydrochlorothiazide, Amlodipine Besilate + Olmesartan Medoxomil, Warfarin Sodium, Telmisartan + Hydrochlorothiazide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Olmenor by Delta Pharma PLC. has the same ingredient and strength for ৳8.00 per unit, compared with ৳14.00 for Olmelo. Ask your doctor or pharmacist before switching.
Do I need a prescription for Olmelo?
Olmelo is a prescription (Rx) medicine. Take it as your doctor advises.