Pricing
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Other strengths and forms by Navana Pharmaceuticals Ltd.
Indications & Uses
Nortin is indicated for:
Pharmacology
Nortriptyline is a dibenzocycloheptadiene tricyclic antidepressant and is the primary active metabolite of amitriptyline. In the central nervous system (CNS), it raises the synaptic concentration of serotonin and/or norepinephrine by blocking the neuronal reuptake of these two neurotransmitters.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Depression: start with a low dose and increase gradually as needed, up to 75-100 mg daily (either divided through the day or as one single dose); do not exceed 150 mg daily. In adolescents and elderly patients, 30-50 mg daily in divided doses is usual. For nerve (neuropathic) pain: start at 10 mg daily at night, raising gradually if needed to 75 mg daily; doses above this should only be used under a specialist's supervision. Or take as directed by your physician.
Side Effects
Dry mouth, constipation, blurred vision, tremor, sedation, sweating, rashes, and behavioral disturbances may occur.
Cautions & Contraindications
Warnings & Precautions
Nortin should be used cautiously in patients with cardiovascular disease, including heart failure or arrhythmias, and such patients should have their heart function and ECG monitored during treatment. At high doses, it has been reported to cause QTc prolongation, arrhythmias, sinus tachycardia, and slowed conduction. Myocardial infarction and stroke have also been reported with drugs of this class.
Contraindications
Concurrent use with a monoamine oxidase (MAO) inhibitor is contraindicated, as hyperpyretic crises, severe convulsions, and fatalities have been reported when similar tricyclic antidepressants were combined with these drugs. The MAO inhibitor should be stopped at least two weeks before starting Nortriptyline. Nortriptyline must not be given to patients who are hypersensitive to it, and caution is warranted since cross-sensitivity with other dibenzazepine compounds is possible. Its use is also contraindicated during the acute recovery phase following a myocardial infarction.
Pregnancy & Breastfeeding
Nortriptyline is classed as Pregnancy Category C. It should be used during pregnancy only when a doctor thinks it is necessary. Doctors weigh the risks of leaving depression untreated against the risks of the medicine, and the medicine should be taken under close supervision from a physician.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
A toxic overdose of nortriptyline can cause confusion, restlessness, agitation and vomiting. Other effects include hyperpyrexia (a very high body temperature), muscle rigidity, hyperactive reflexes and tachycardia (a fast heartbeat). The ECG may show impaired conduction. Shock, congestive heart failure, stupor and coma can follow. There may also be CNS stimulation with convulsions, followed by respiratory depression. Deaths have occurred after overdose with drugs of this class.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Nortriptyline in a cool, dry place and away from light. Make sure children can't reach it.
Drug Interactions
Common questions about Nortin 25 mg
What is Nortin 25 mg Capsule?
Nortin 25 mg Capsule is a medicine that contains Nortriptyline. It is made by Navana Pharmaceuticals Ltd. It belongs to the Tricyclic & related anti-depressant drugs group of medicines.
What is Nortin used for?
Nortin is used for: Neuropathic Pain, Pain, Depression.
What are the side effects of Nortin?
Dry mouth, constipation, blurred vision, tremor, sedation, sweating, rashes, and behavioral disturbances may occur.
Can I take Nortin during pregnancy or while breastfeeding?
Nortriptyline is classed as Pregnancy Category C. It should be used during pregnancy only when a doctor thinks it is necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nortin?
A toxic overdose of nortriptyline can cause confusion, restlessness, agitation and vomiting. Other effects include hyperpyrexia (a very high body temperature), muscle rigidity, hyperactive reflexes and tachycardia (a fast heartbeat). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nortin?
Keep Nortriptyline in a cool, dry place and away from light. Make sure children can't reach it.
Can I take other medicines with Nortin?
Some medicines can interact with Nortriptyline, for example: Rifampicin + Isoniazid, Cimetidine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Nortin is already among the lowest-priced brands of Nortriptyline at this strength.
Do I need a prescription for Nortin?
Nortin is a prescription (Rx) medicine. Take it as your doctor advises.