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Allylestrenol is used in intra uterine growth retardation (IUGR), threatened abortion, habitual abortion and threatened premature delivery.
Pharmacology
Allylestrenol has a fairly weak progestational effect on the human endometrium. In oestrogen-primed castrated women, getting a full secretory endometrium needed higher doses than those recommended for treating or preventing abortion. The same was true when menstruation was postponed (with an oestrogen added) in normal ovulating women.
In vitro studies showed that allylestrenol stimulates the synthesis of progesterone in the human placenta. It also brought about a significant (p/. 0,01) increase in the production of some specific placental enzymes, cystine aminopeptidase and heat-stable alkaline phosphatase.
In women with a normal pregnancy and in those with a threatened pregnancy, treatment with allylestrenol led to histological and histochemical changes that point to increased activity in the placenta, particularly in the syncytiotrophoblast. The effect on placental function was also suggested by higher levels of placental hormones (pregnanediol, oestriol, HCG and HPL) and enzymes (oxytocinase, CAP) in the maternal urine and plasma. These rises followed administration of the drug, for example in the early weeks as well as in the last trimester of pregnancy.
A study in full-term pregnant women found that allylestrenol in high doses (up to 100 mg daily) did suppress the intensity of spontaneous uterine contractions. It had no effect on how sensitive the uterine muscle is to oxytocin, and no adverse effect on the progress of normal delivery.
Studies in non-pregnant women, with and without endocrinological disorders, showed that allylestrenol has no oestrogenic or androgenic properties and no adverse effects on adrenal function.
Healthy non-pregnant female volunteers who were given allylestrenol showed no abnormal liver function tests and no water or salt retention.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Allylestrenol for intra uterine growth retardation is 1 tablet three times a day for at least two months. The dose should be reduced if symptoms improve.
For threatened abortion, take 1 tablet three times daily until the symptoms disappear.
For habitual abortion, the dose is 1 to 2 tablets daily, starting as soon as pregnancy is diagnosed. Keep giving it for at least one month after the end of the critical period.
For threatened premature delivery, the dose must be decided for each patient individually. High doses, up to 40 mg daily, have been used.
If a dose is missed, the patient should take it as soon as she remembers and then carry on with the regular schedule. A double dose is not recommended.
Side Effects
Allylestrenol can cause some stomach and gut complaints, mostly with long term treatment. These include vomiting and nausea, and sometimes discomfort in the upper abdomen (the epigastric area).
Cautions & Contraindications
Warnings & Precautions
Take care with Allylestrenol if you have heart disease, congestive heart failure, sick sinus syndrome or coronary artery disease. The same goes for seizures, epilepsy, renal dysfunction and migraine headaches. People with breathing diseases, including asthma, emphysema, chronic bronchitis or COPD, should also be careful, and so should women who are breast-feeding.
Contraindications
Allylestrenol should not be used in people with breast cancer, or with a history of breast problems such as nodules, an abnormal mammogram or fibrocystic disease. It should also be avoided in severe liver disease, such as cholestatic jaundice or hepatitis, and in hepatic cell tumours, Rotor syndrome and Dubin Jhonson syndrome. Other conditions where it must not be used are undiagnosed vaginal bleeding, toxaemia of pregnancy, crisis seizures and migraines.
Pregnancy & Breastfeeding
Allylestrenol is made for use during pregnancy. Stop taking it after delivery, because it may affect a nursing infant to a small but noticeable degree.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Allylestrenol should not be given to children younger than 16 years old.
Overdose
An overdose of Allylestrenol may cause unusual drowsiness, a rapid pulse and fainting. Some people also have unusual muscle movement or rigidity of the face, neck or limbs, along with seizures and loss of consciousness.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Allylestrenol below 30°C, away from light and moisture. Keep it out of the reach of children.
Common questions about Nidagest 5 mg
What is Nidagest 5 mg Tablet?
Nidagest 5 mg Tablet is a medicine that contains Allylestrenol. It is made by Chemist Laboratories Ltd. It belongs to the Female Sex hormones group of medicines.
What is Nidagest used for?
Allylestrenol is used in intra uterine growth retardation (IUGR), threatened abortion, habitual abortion and threatened premature delivery.
What are the side effects of Nidagest?
Allylestrenol can cause some stomach and gut complaints, mostly with long term treatment. These include vomiting and nausea, and sometimes discomfort in the upper abdomen (the epigastric area).
Can I take Nidagest during pregnancy or while breastfeeding?
Allylestrenol is made for use during pregnancy. Stop taking it after delivery, because it may affect a nursing infant to a small but noticeable degree. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nidagest?
An overdose of Allylestrenol may cause unusual drowsiness, a rapid pulse and fainting. Some people also have unusual muscle movement or rigidity of the face, neck or limbs, along with seizures and loss of consciousness. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nidagest?
Store Allylestrenol below 30°C, away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Nidagest is already among the lowest-priced brands of Allylestrenol at this strength.
Do I need a prescription for Nidagest?
Nidagest is a prescription (Rx) medicine. Take it as your doctor advises.