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Indications & Uses
Nicin is indicated for:
Pharmacology
Natamycin is a tetraene polyene antibiotic obtained from Streptomyces natalensis. It is thought to work against fungi by binding to sterols in the fungal cell membrane, which alters membrane permeability and lets essential cellular contents leak out. It shows in vitro activity against several yeasts and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. While its antifungal action is dose-related, Natamycin is mainly fungicidal. Applied topically, it appears to reach effective concentrations within the corneal stroma, but not within the intraocular fluid.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For fungal keratitis: the preferred starting dose is 1 drop placed in the conjunctival sac(s) every 1 to 2 hours. After the first 3 to 4 days, the frequency can usually be reduced to 1 drop 6 to 8 times a day. Treatment should generally continue for 14 to 21 days, or until the active fungal keratitis has cleared. For fungal blepharitis and conjunctivitis: 1 drop 4 to 6 times a day may be enough. Pediatric use: safety and effectiveness in pediatric patients have not been established.
Side Effects
Eye irritation, eye discomfort, swelling of the eye, and swelling and redness of the conjunctiva (conjunctival chemosis and hyperaemia) have been reported.
Cautions & Contraindications
Warnings & Precautions
Do not let the dropper tip touch any surface, as this may contaminate the suspension. Patients should be advised not to wear contact lenses if they have signs and symptoms of fungal blepharitis, conjunctivitis or keratitis. If keratitis does not improve after 7 to 10 days of treatment, the infection may be caused by a microorganism that is not susceptible to Natadrop. Whether to continue therapy should be decided on the basis of clinical re-evaluation and additional laboratory studies. The suspension regularly adheres to areas of epithelial ulceration or is retained in the fornices.
Contraindications
Natamycin ophthalmic suspension should not be used in people who have a history of hypersensitivity to any of its components.
Pregnancy & Breastfeeding
Pregnancy category C. No animal reproduction studies have been carried out with Natamycin, and it is not known whether the drug can harm the fetus or affect fertility when used by a pregnant woman. For this reason, Natamycin ophthalmic suspension should be used during pregnancy only if there is a clear need for it. It is also not known whether Natamycin passes into human breast milk. Since many medicines do pass into breast milk, it should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Natamycin in a cool, dry place and away from light. Don't let it freeze. Once you have opened the bottle, don't use it for longer than one month.
Common questions about Nicin 5%
What is Nicin 5% Ophthalmic Suspension?
Nicin 5% Ophthalmic Suspension is a medicine that contains Natamycin. It is made by Nipa Pharmaceuticals Ltd. It belongs to the Ophthalmic antibacterial drugs group of medicines.
What is Nicin used for?
Nicin is used for: Bacterial Infection, Conjunctivitis.
What are the side effects of Nicin?
Eye irritation, eye discomfort, swelling of the eye, and swelling and redness of the conjunctiva (conjunctival chemosis and hyperaemia) have been reported.
Can I take Nicin during pregnancy or while breastfeeding?
Pregnancy category C. No animal reproduction studies have been carried out with Natamycin, and it is not known whether the drug can harm the fetus or affect fertility when used by a pregnant woman. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Nicin?
Keep Natamycin in a cool, dry place and away from light. Don't let it freeze.
Do I need a prescription for Nicin?
Nicin is a prescription (Rx) medicine. Take it as your doctor advises.