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Rx50 mg • Tablet (Extended Release)
More from Nevola
Other strengths and forms by Ziska Pharmaceuticals Ltd.
Indications & Uses
Desvenlafaxine Succinate is used to treat Major Depressive Disorder (MDD). Doctors generally agree that an acute episode of major depressive disorder needs several months or longer of steady treatment with medicine. Patients should be reassessed from time to time, so the doctor can decide whether they still need to continue treatment.
Pharmacology
Desvenlafaxine is a synthetic form of the main active metabolite of Venlafaxine, taken on its own, and it belongs to the group of medicines called Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). It blocks the transporter reuptake protein for key neurotransmitters that affect mood, so more of the active neurotransmitters stay in the synapse. The two neurotransmitters involved are Serotonin (5-hydroxytryptamine) and Norepinephrine (Noradrenaline). Desvenlafaxine is approximately 10 times more potent at inhibiting Serotonin uptake than Norepinephrine uptake.
The exact way Desvenlafaxine works against depression is not known. It is thought to be linked to potentiation of Serotonin and Norepinephrine in the central nervous system, through inhibition of their reuptake. Non-clinical studies have shown that Desvenlafaxine is a potent Serotonin and Norepinephrine Reuptake Inhibitor (SNRI).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Desvenlafaxine Succinate is 50 mg once daily, and you can take it with or without food. In clinical studies, doses from 50 to 400 mg/day were shown to be effective. Try to take it at about the same time each day.
Swallow the tablet whole with some fluid. Don't divide, crush or chew it, and don't dissolve it either.
When the treatment is being stopped, the dose should be reduced gradually whenever possible, so that discontinuation symptoms are kept to a minimum.
Side Effects
Desvenlafaxine Succinate can cause nausea, dizziness, insomnia, heavy sweating (hyperhidrosis), constipation, sleepiness (somnolence), decreased appetite, anxiety and dry mouth. Some men may also have specific problems with sexual function.
Cautions & Contraindications
Warnings & Precautions
Patients with Major Depressive Disorder (MDD), both adults and children, may find their depression getting worse. They may also develop suicidal thoughts and behaviour (suicidality) or show unusual changes in behaviour. This can happen whether or not they are taking an antidepressant medicine such as desvenlafaxine succinate, and the risk may last until the depression has improved significantly. Short-term placebo-controlled studies of antidepressants (SSRIs and others) were pooled and analysed. They showed that these medicines increase the risk of suicidal thinking and behaviour in children, adolescents and young adults (aged 18 to 24) with MDD and other psychiatric disorders. In adults older than 24, the short-term studies did not show a higher risk of suicidality with antidepressants than with placebo.
Contraindications
Don't give Desvenlafaxine Succinate to anyone who is hypersensitive to Desvenlafaxine Succinate, to Venlafaxine Hydrochloride, or to any of the excipients in the Desvenlafaxine formulation. It must also not be used together with MAOIs (Mono Amine Oxidase Inhibitors) that are meant to treat psychiatric disorders. The same applies if the MAOI was taken within 7 days of stopping Desvenlafaxine. And Desvenlafaxine is also contraindicated within 14 days of stopping an MAOI intended to treat psychiatric disorders.
Pregnancy & Breastfeeding
Desvenlafaxine is Pregnancy Category C. Use it during pregnancy only if the possible benefits justify the possible risks to the fetus.
Desvenlafaxine (O-desmethylvenlafaxine) passes into human milk. Because it can cause serious adverse reactions in a nursing infant, a decision should be made whether to stop nursing or to stop the medicine, taking into account how important the medicine is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Dosage Adjustment in Renal Impairment
Patients with mild renal impairment don't need any dosage adjustment. For moderate renal impairment, the recommended dose of Desvenlafaxine is 50 mg per day. For severe renal impairment or End-Stage Renal Disease (ESRD), the recommended dose is a maximum of 50 mg every other day. Don't give a supplemental dose after dialysis. And the dose should not be escalated in patients with moderate or severe renal impairment or ESRD.
Dosage Adjustment in Hepatic Impairment
The recommended dose in patients with hepatic impairment is 50 mg/day. A maximum of 100 mg/day is not recommended.
Storage
Store Desvenlafaxine Succinate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Nevola 50 mg
What is Nevola 50 mg Tablet (Extended Release)?
Nevola 50 mg Tablet (Extended Release) is a medicine that contains Desvenlafaxine Succinate. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Serotonin-norepinephrine reuptake inhibitor (SNRI) group of medicines.
What is Nevola used for?
Desvenlafaxine Succinate is used to treat Major Depressive Disorder (MDD). Doctors generally agree that an acute episode of major depressive disorder needs several months or longer of steady treatment with medicine.
What are the side effects of Nevola?
Desvenlafaxine Succinate can cause nausea, dizziness, insomnia, heavy sweating (hyperhidrosis), constipation, sleepiness (somnolence), decreased appetite, anxiety and dry mouth. Some men may also have specific problems with sexual function.
Can I take Nevola during pregnancy or while breastfeeding?
Desvenlafaxine is Pregnancy Category C. Use it during pregnancy only if the possible benefits justify the possible risks to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Nevola?
Store Desvenlafaxine Succinate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Nevola?
Some medicines can interact with Desvenlafaxine Succinate, for example: Venlafaxine, Tolterodine Tartrate, Nebivolol, Metoprolol Tartrate, Dextromethorphan Hydrobromide, Atomoxetine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Nevola is already among the lowest-priced brands of Desvenlafaxine Succinate at this strength.
Do I need a prescription for Nevola?
Nevola is a prescription (Rx) medicine. Take it as your doctor advises.