Indications & Uses
Nevalto 5/80 is indicated for:
Pharmacology
Nebivolol is a cardiovascular medicine from the group of selective beta-blockers (that is, it acts selectively on the cardiovascular system). It stops the heart rate from rising and controls how strongly the heart pumps. It also widens the blood vessels, which helps lower blood pressure. Valsartan works by blocking the angiotensin II receptor, acting on the AT1 subtype. This dilates the blood vessels and brings blood pressure down without affecting the pulse rate.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Nebivolol + Valsartan is one 5 mg/80 mg (nebivolol/valsartan) tablet, taken by mouth once daily. It can be used as the first treatment, and also for patients whose blood pressure is not adequately controlled on valsartan 80 mg or on nebivolol up to and including 10 mg. The full blood pressure lowering effect is reached within 2 to 4 weeks. Raising the dose of nebivolol/valsartan 5/80 does not bring any meaningful further fall in blood pressure. Patients who already take 5 mg nebivolol and 80 mg valsartan separately can switch to the 5/80 tablet in place of the two components.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Warnings & Precautions
Stopping Nebivolol + Valsartan can bring on an acute worsening of coronary artery disease, so don't stop it suddenly. In people with diabetes, glucose should be monitored, because beta-blockers may mask the symptoms of hypoglycemia. In susceptible patients, renal function and potassium level need to be monitored.
Contraindications
Nebivolol + Valsartan should not be used in any of these conditions: severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, and sick sinus syndrome (unless a permanent pacemaker is in place). It is also contraindicated in patients with severe hepatic impairment (Child-Pugh >B) and in patients who are hypersensitive to any component of this product. Aliskiren should not be co-administered with 5/80 in patients with diabetes.
Pregnancy & Breastfeeding
Nebivolol + Valsartan can cause harm to the baby if it is given to a pregnant woman, so it is not recommended during pregnancy. Mothers are also advised not to breastfeed while taking it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Safety and effectiveness in pediatric patients have not been established.
Geriatric use: Elderly patients and younger patients showed no overall differences in safety or effectiveness. Other reported clinical experience has not found any difference in response either.
Renal impairment: Nebivolol/Valsartan is not recommended as initial treatment in patients with severe renal impairment, because the recommended starting dose of nebivolol in this population is 2.5 mg once daily.
Hepatic impairment: There are no studies of Nebivolol/Valsartan in patients with hepatic insufficiency.
Overdose
Nebivolol: if an overdose happens, give general supportive care and treat the specific symptoms as they appear.
Bradycardia: give IV atropine.
Hypotension: give IV fluids and vasopressors. Intravenous glucagon may be useful.
Heart block (second or third degree): monitor the patient and treat with an isoproterenol infusion. In some situations a transthoracic or transvenous pacemaker may be needed.
Congestive heart failure: start therapy with a digitalis glycoside and diuretics. In certain cases, consider inotropic and vasodilating agents.
Bronchospasm: give bronchodilator therapy, such as a short acting inhaled 2-agonist and/or aminophylline.
Hypoglycemia: give IV glucose. Repeated doses of IV glucose, or possibly glucagon, may be required.
Supportive measures should continue until the patient is clinically stable. The half-life of low doses of nebivolol is 12-19 hours.
Valsartan: there are only limited data on valsartan overdosage in humans. The most likely signs would be hypotension and tachycardia, and bradycardia could occur from parasympathetic (vagal) stimulation. Valsartan is not removed from the plasma by hemodialysis.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Nebivolol + Valsartan at a temperature not above 30°C, in a dry place. Protect it from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Nevalto 5/80 5 mg
What is Nevalto 5/80 5 mg Tablet?
Nevalto 5/80 5 mg Tablet is a medicine that contains Nebivolol + Valsartan. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Nevalto 5/80 used for?
Nevalto 5/80 is used for: Hypertension.
Can I take Nevalto 5/80 during pregnancy or while breastfeeding?
Nebivolol + Valsartan can cause harm to the baby if it is given to a pregnant woman, so it is not recommended during pregnancy. Mothers are also advised not to breastfeed while taking it. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nevalto 5/80?
Nebivolol: if an overdose happens, give general supportive care and treat the specific symptoms as they appear. Bradycardia: give IV atropine. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nevalto 5/80?
Store Nebivolol + Valsartan at a temperature not above 30°C, in a dry place. Protect it from light, and keep it out of the reach of children.
Can I take other medicines with Nevalto 5/80?
Some medicines can interact with Nebivolol + Valsartan, for example: Nebivolol, Clonidine Hydrochloride, Verapamil Hydrochloride, Diltiazem Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nevalto 5/80?
Nevalto 5/80 is a prescription (Rx) medicine. Take it as your doctor advises.