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Indications & Uses
Ferric Pyrophosphate Citrate is used to replace iron so that hemoglobin can be maintained in adult patients with hemodialysis-dependent chronic kidney disease (HDD-CKD).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Before you mix Ferric Pyrophosphate Citrate into the bicarbonate concentrate, look at the ampoule for any sign of precipitation. Ferric Pyrophosphate Citrate should only be added to the bicarbonate concentrate, never to acid concentrate mixtures. It goes into the bicarbonate concentrate that is used to make the hemodialysate. The final concentration of iron (III) in the final hemodialysate is 2 micromolar (110 mcg/L). At each center, several ampoules can be added to the master bicarbonate mix, at a ratio of one ampoule to each 2.5 gallons of bicarbonate concentrate.
Administer Ferric Pyrophosphate Citrate to patients at every dialysis procedure, for as long as they are receiving maintenance hemodialysis therapy for CKD.
Use the hemodialysis solutions within 24 hours of preparing the Ferric Pyrophosphate Citrate/bicarbonate concentrate mixture.
Side Effects
The most common side effects of Ferric Pyrophosphate Citrate are headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, hypotension, muscle spasms, pain in extremity, back pain and dyspnea.
Cautions & Contraindications
Warnings & Precautions
Hypersensitivity reactions can happen with Ferric Pyrophosphate Citrate. These include anaphylactic-type reactions, shock, low blood pressure (hypotension), loss of consciousness and collapse. Watch the patient for signs and symptoms of hypersensitivity during hemodialysis and after it, until he or she is clinically stable. Staff and treatments should be immediately available to manage any serious hypersensitivity reaction. Iron laboratory testing Iron status should be checked on blood samples taken before dialysis. Samples taken after dialysis may overestimate serum iron and transferrin saturation.
Pregnancy & Breastfeeding
Pregnant women: Ferric Pyrophosphate Citrate is Pregnancy Category C.
Breastfeeding mothers: it is not known whether Ferric Pyrophosphate Citrate is present in human milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no information available on overdose with Ferric Pyrophosphate Citrate.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Ferric Pyrophosphate Citrate in a cool, dry place, away from light. Keep it out of reach of children.
Common questions about Nepofer 27.2 mg/5 ml
What is Nepofer 27.2 mg/5 ml IV Infusion?
Nepofer 27.2 mg/5 ml IV Infusion is a medicine that contains Ferric Pyrophosphate Citrate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Parenteral Iron Preparations group of medicines.
What is Nepofer used for?
Ferric Pyrophosphate Citrate is used to replace iron so that hemoglobin can be maintained in adult patients with hemodialysis-dependent chronic kidney disease (HDD-CKD).
What are the side effects of Nepofer?
The most common side effects of Ferric Pyrophosphate Citrate are headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, hypotension, muscle spasms, pain in extremity, back pain and dyspnea.
Can I take Nepofer during pregnancy or while breastfeeding?
Pregnant women: Ferric Pyrophosphate Citrate is Pregnancy Category C. Breastfeeding mothers: it is not known whether Ferric Pyrophosphate Citrate is present in human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nepofer?
There is no information available on overdose with Ferric Pyrophosphate Citrate. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nepofer?
Store Ferric Pyrophosphate Citrate in a cool, dry place, away from light. Keep it out of reach of children.
Do I need a prescription for Nepofer?
Nepofer is a prescription (Rx) medicine. Take it as your doctor advises.