More from Nebactil
Other strengths and forms by Beximco Pharmaceuticals Ltd.
Indications & Uses
Nebactil is indicated for:
Pharmacology
Nalidixic acid is a synthetic antibacterial with a narrow spectrum of activity. Depending on the concentration used, it can either stop bacteria from multiplying or kill them outright. It works by blocking bacterial DNA synthesis, likely by interfering with the DNA polymerization process. After oral dosing, it is absorbed quickly and almost completely from the gastrointestinal tract, and the parent drug along with its active metabolites reach most body tissues, with especially high concentrations in the kidney and urine. When kidney function is normal, its half-life runs from 1.1 to 2.5 hours; if kidney function is impaired, this can stretch to as long as 21 hours. The drug is cleared from the body quickly, with excretion nearly complete within 24 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Initially, 1 g every 6 hours for 7 days, then reduced to 500 mg every 6 hours. Children: For infants and children aged 3 months and over, the initial dose is 13.75 mg per kg of body weight by mouth every six hours for one or two weeks. The maintenance dose is 8.25 mg per kg of body weight by mouth every six hours, or as prescribed by the physician.
Side Effects
Gastro-intestinal disturbances such as nausea, vomiting and diarrhoea may occur. Haemolysis can develop in people with G6PD deficiency. Allergic reactions may include urticaria, rashes, fever, arthralgia and eosinophilia. Other possible side effects are myalgia, muscle weakness, phototoxicity, jaundice, visual disturbances and convulsions.
Cautions & Contraindications
Warnings & Precautions
The benefits and risks should be weighed carefully before use during the first trimester of pregnancy, while breastfeeding, and in patients with impaired kidney or liver function.
Contraindications
Nalidixic acid should not be used in infants under 3 months of age, in people with epilepsy, or in those with CNS (central nervous system) lesions.
Pregnancy & Breastfeeding
There is a possibility that nalidixic acid may damage cartilage. Because it works by inhibiting DNA gyrase, it may also cause DNA damage. Nalidixic acid passes into breast milk, and there is a report of haemolytic anaemia in a breastfed child whose mother had azotaemia.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Nalidixic Acid below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Nebactil 300 mg
What is Nebactil 300 mg Powder For Suspension?
Nebactil 300 mg Powder For Suspension is a medicine that contains Nalidixic Acid. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Anti-diarrhoeal antimicrobial drugs group of medicines.
What is Nebactil used for?
Nebactil is used for: Urinary Tract Infection.
What are the side effects of Nebactil?
Gastro-intestinal disturbances such as nausea, vomiting and diarrhoea may occur. Haemolysis can develop in people with G6PD deficiency.
Can I take Nebactil during pregnancy or while breastfeeding?
There is a possibility that nalidixic acid may damage cartilage. Because it works by inhibiting DNA gyrase, it may also cause DNA damage. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Nebactil?
Store Nalidixic Acid below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Nebactil?
Some medicines can interact with Nalidixic Acid, for example: Melphalan, Carica Papaya Leaf Extract, Methoxsalen, Chlorpromazine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nebactil?
Nebactil is a prescription (Rx) medicine. Take it as your doctor advises.