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Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Nalbun is indicated for:
Pharmacology
Nalbuphine Hydrochloride is a potent synthetic analgesic, with pain-relieving strength essentially equal to that of morphine on a milligram-for-milligram basis. Receptor studies show that it binds to mu, kappa, and delta receptors, but not to sigma receptors, acting primarily as a kappa agonist with partial mu-antagonist activity. Given intravenously, it starts working within 2 to 3 minutes; given subcutaneously or intramuscularly, it takes effect in under 15 minutes. Its plasma half-life is about 5 hours, and clinical studies have found its pain-relieving effect to last anywhere from 3 to 6 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual recommended adult dose is 10 mg for a 70 kg individual, given by intramuscular or intravenous injection; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, the physical condition of the patient, and other medications the patient may be receiving.
For moderate to severe pain, the intravenous or intramuscular dose is 10 to 20 mg for a 70 kg patient, adjusted as required; for a child, up to 0.3 mg/kg, repeated once or twice as necessary.
For preoperative anesthesia, the intravenous or intramuscular dose is 0.1 to 0.2 mg/kg.
For obstetrical analgesia during labor and delivery, the intravenous dose is 0.3 to 1 mg/kg given over 10 to 15 minutes, with maintenance doses of 0.25 to 0.5 mg/kg given as a single intravenous administration as required.
For intraoperative analgesia, the intravenous dose is 0.25 to 0.5 mg/kg at 30 minute intervals.
For myocardial infarction, the dose is 10 to 20 mg by slow intravenous injection, repeated after 30 minutes if necessary. A larger dose is required when nalbuphine is used as a supplement to anesthesia than when it is used for analgesia alone.
For children from 18 months to 15 years old, the usual dose is 0.2 mg/kg body weight, given preferably by intravenous or intramuscular injection. Maintenance doses may be given at intervals of 4 to 6 hours, or the dose may be determined by the physician.
Side Effects
Generally, Raltrox is well tolerated. A few people may notice side effects such as sedation, sweating, nausea, vomiting, dizziness, vertigo, dry mouth, headache, respiratory depression, breathlessness, or asthma.
Cautions & Contraindications
Warnings & Precautions
Nalbuphine should be used with care in people who have impaired breathing, reduced kidney or liver function, or who are having biliary tract surgery. Caution is also needed after a myocardial infarction and in people with low blood pressure (hypotension).
Contraindications
Don't give Nalbuphine Hydrochloride to anyone known to be hypersensitive to it.
Pregnancy & Breastfeeding
Pregnancy category B. Nalbuphine crosses the placenta readily and quickly, and there are no well-controlled studies in pregnant women, so it should be used in pregnancy only when clearly needed. Limited data show that small amounts pass into breast milk (under 1% of the maternal dose), with no expected clinical effect on the infant; even so, caution is advised when giving Nalbuphine to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Nalbuphine Hydrochloride can cause sleepiness and mild dyspnea (difficulty in breathing). The specific antidote is an opiate antagonist such as Naloxone or Nalmefene, and it should be given intravenously straight away. Other supportive measures should be used as indicated, including oxygen, intravenous fluids and vasopressors.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Nalbuphine Hydrochloride below 30°C and protect it from light. Keep it out of reach of children.
Drug Interactions
Common questions about Nalbun 20 mg/2 ml
What is Nalbun 20 mg/2 ml IM/IV Injection?
Nalbun 20 mg/2 ml IM/IV Injection is a medicine that contains Nalbuphine Hydrochloride. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Opioid analgesics group of medicines.
What is Nalbun used for?
Nalbun is used for: Myocardial Infarction, Pain.
What are the side effects of Nalbun?
Generally, Raltrox is well tolerated. A few people may notice side effects such as sedation, sweating, nausea, vomiting, dizziness, vertigo, dry mouth, headache, respiratory depression, breathlessness, or asthma.
Can I take Nalbun during pregnancy or while breastfeeding?
Pregnancy category B. Nalbuphine crosses the placenta readily and quickly, and there are no well-controlled studies in pregnant women, so it should be used in pregnancy only when clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nalbun?
An overdose of Nalbuphine Hydrochloride can cause sleepiness and mild dyspnea (difficulty in breathing). The specific antidote is an opiate antagonist such as Naloxone or Nalmefene, and it should be given intravenously straight away. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nalbun?
Store Nalbuphine Hydrochloride below 30°C and protect it from light. Keep it out of reach of children.
Can I take other medicines with Nalbun?
Some medicines can interact with Nalbuphine Hydrochloride, for example: Morphine Sulfate, Tapentadol Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nalbun?
Nalbun is a prescription (Rx) medicine. Take it as your doctor advises.