More from Monocard
Other strengths and forms by Drug International Unani Ltd.
Indications & Uses
Monocard is indicated for:
Pharmacology
Isosorbide mononitrate is the major active metabolite of isosorbide dinitrate (ISDN), and most of the clinical activity of the dinitrate is attributable to the mononitrate. The principal pharmacological action of isosorbide mononitrate is relaxation of vascular smooth muscle, which leads to dilatation of the peripheral arteries and veins, especially the veins. Widening of the veins allows blood to pool in the periphery and reduces the amount returning to the heart, thereby lowering left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Relaxation of the arterioles reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). The coronary arteries also dilate as a result of this action. How much each of these effects (preload reduction, afterload reduction, and coronary dilatation) contributes to the overall benefit is not yet clearly established.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual oral dose of Isosorbide Mononitrate is 1 tablet (20 mg) taken 2 times daily. Take the first dose in the morning and the second 7 hours later. Maintenance doses can range from 20 mg to 120 mg (1 to 6 tablets). A dose of 10 mg (1/2 tablet) is suitable when a lower dose is wanted at the start of treatment, or as directed by a registered physician.
Dosage for other forms (1)
The usual oral dose is 1 capsule (50 mg) once daily, or as directed by a registered physician.
Side Effects
Headache and dizziness may occur, and blood pressure can sometimes drop (hypotension).
Cautions & Contraindications
Warnings & Precautions
Severe drops in blood pressure, especially when a person stands up, can happen even with small doses of Angifix. So it should be used carefully in people who are short of fluid in the body or who already have low blood pressure for any reason. Low blood pressure caused by Angifix may come with a slow heartbeat that works the wrong way, and with worse angina. Nitrate treatment can also make the chest pain caused by hypertrophic cardiomyopathy worse. Industrial workers who were exposed to organic nitrates over many years, at doses that were probably high but not known, clearly built up a tolerance to them. When these workers had their nitrates stopped for a while, they developed chest pain, acute myocardial infarction, and even sudden death. This shows that a real physical dependence can develop. How much this matters for the routine clinical use of oral Angifix is not known. Patients should know that Angifix tablets keep working against angina as long as the prescribed schedule is followed closely, which means two doses taken seven hours apart. For most people this is easy to manage: take the first dose when you wake up and the second dose 7 hours later. As with other nitrates, daily headaches sometimes come with Angifix. For people who get them, the headache is a sign that the medicine is active. Please don't try to avoid the headaches by changing the timing of your Angifix doses, because losing the headache may mean you are losing the anti-angina effect at the same time. Aspirin and/or acetaminophen often relieve Angifix headaches well, and they don't reduce how well Angifix works against angina. Angifix can cause light-headedness when you stand up, particularly right after getting up from lying down or sitting. This is more likely if you have also been drinking alcohol.
Contraindications
Isosorbide mononitrate should not be used in patients who are allergic to it. Do not use Isosorbide Mononitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. Taking these together can cause severe hypotension, syncope, or myocardial ischemia. Do not use Isosorbide Mononitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat, since taking them together can cause hypotension.
Pregnancy & Breastfeeding
Pregnancy Category B: In reproduction studies, rats given up to 540 mg/kg/day and rabbits given up to 810 mg/kg/day showed no evidence that isosorbide mononitrate harmed the fetus. However, no adequate, well-controlled studies have been done in pregnant women, and animal studies do not always predict how humans will respond. For this reason, Isosorbide Mononitrate should be used in pregnancy only when the need is clear.
Nursing Mothers: It is not known whether isosorbide mononitrate passes into human breast milk. Since many drugs do pass into breast milk, nursing mothers should be given isosorbide mononitrate with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Isosorbide Mononitrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Monocard 10 mg
What is Monocard 10 mg Tablet?
Monocard 10 mg Tablet is a medicine that contains Isosorbide Mononitrate. It is made by Drug International Unani Ltd. It belongs to the Nitrates: Coronary vasodilators group of medicines.
What is Monocard used for?
Monocard is used for: Angina Pectoris.
What are the side effects of Monocard?
Headache and dizziness may occur, and blood pressure can sometimes drop (hypotension).
Can I take Monocard during pregnancy or while breastfeeding?
Pregnancy Category B: In reproduction studies, rats given up to 540 mg/kg/day and rabbits given up to 810 mg/kg/day showed no evidence that isosorbide mononitrate harmed the fetus. However, no adequate, well-controlled studies have been done in pregnant women, and animal studies do not always predict how humans will respond. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Monocard?
Store Isosorbide Mononitrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Monocard?
Some medicines can interact with Isosorbide Mononitrate, for example: Levosimendan. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Monocard?
Monocard is a prescription (Rx) medicine. Take it as your doctor advises.