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These brands contain the same active ingredient (Fluoxetine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Fluoxetine Hydrochloride is used to treat depressive illness, bulimia nervosa and obsessive compulsive disorder.
Pharmacology
Fluoxetine selectively blocks the reuptake of serotonin at the presynaptic neuronal membrane. This raises the concentration of serotonin in the synapse in the CNS, and that leads to many functional changes linked to stronger serotonergic neurotransmission. Fluoxetine appears to have no effect on the reuptake of norepinephrine and dopamine. At usual therapeutic doses it also shows no anticholinergic, antihistaminic or α1 adrenergic blocking activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Initial treatment
Recent studies suggest that 20 mg/day of Fluoxetine may be enough to get a satisfactory antidepressant response. So the recommended starting dose is 20 mg/day, taken in the morning. If there's no clinical improvement after several weeks, a dose increase may be considered. Any dose above 20 mg/day should be given twice a day (bid), in the morning and at noon, and the total should not go above the maximum of 80 mg/day. As with other antidepressants, the full antidepressant effect may be delayed until 4 weeks of treatment or longer. As with many other medicines, patients with renal and/or hepatic impairment should be given a lower or less frequent dosage. A lower or less frequent dosage should also be considered for patients such as the elderly, those with concurrent disease or those on multiple medicines. The recommended maximum dose for elderly patients is 60 mg per day.
Maintenance treatment
Expert psychopharmacologists generally agree that an acute episode of depression needs sustained drug therapy for several months or longer. Fluoxetine is also used at a dose of 60 mg daily for the management of bulimia nervosa.
Use in children
Fluoxetine is not recommended for children, because its safety and efficacy have not been established.
Side Effects
Gastrointestinal: Fluoxetine Hydrochloride can cause nausea, vomiting, dyspepsia, dry mouth and diarrhoea. Neurological: Anxiety, nervousness, insomnia or drowsiness, and fatigue can occur. Others: Excessive sweating, pruritus and skin rashes may occur, and the rashes can be associated with liver, kidney and lung involvement. Because of this, it has been advised that Fluoxetine Hydrochloride therapy should be stopped in any patient who develops a skin rash.
Cautions & Contraindications
Warnings & Precautions
Fluoxetine Hydrochloride is broken down in the liver and cleared through the kidneys. So if a patient has impaired liver or kidney function, it should be used with caution and in reduced doses. It can also cause seizures, which means extra care is needed in people with epilepsy or a history of such disorders. Fluoxetine Hydrochloride may change glycaemic control, so caution is needed in diabetic patients too. Depressed patients with suicidal tendencies should be supervised carefully during treatment. It is not usually considered a suitable therapy for the depressive part of bipolar (manic depressive) illness, because mania may be precipitated.
Contraindications
Fluoxetine Hydrochloride must not be given to anyone known to be hypersensitive to it. Serious, sometimes fatal reactions have been reported in patients who took Fluoxetine together with monoamine oxidase inhibitors (MAOIs). They have also been reported in patients who had recently stopped Fluoxetine and were then started on an MAOI. The reactions included hyperthermia, rigidity, myoclonus, and autonomic instability with possible rapid fluctuations of vital signs. There were also changes of mental status, with extreme agitation progressing to delirium and coma. Some cases looked like neuroleptic malignant syndrome. So Fluoxetine should not be used with an MAOI, or within 14 days of stopping MAOI therapy. Fluoxetine and its major metabolites stay in the body for a very long time (their elimination half-lives are very long), so at least 5 weeks should pass after stopping Fluoxetine before an MAOI is started.
Pregnancy & Breastfeeding
Animal studies found no teratogenicity or other harmful effect with Fluoxetine. But animal reproductive studies don't always predict what happens in humans, so Fluoxetine should be used in pregnancy only if it is clearly needed. Fluoxetine passes into human milk, so take care when it is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Fluoxetine Hydrochloride away from light and moisture. Store it in a cool, dry place, below 30°C. And as with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Modipran 20 mg
What is Modipran 20 mg Capsule?
Modipran 20 mg Capsule is a medicine that contains Fluoxetine Hydrochloride. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Phenothiazine related drugs group of medicines.
What is Modipran used for?
Fluoxetine Hydrochloride is used to treat depressive illness, bulimia nervosa and obsessive compulsive disorder.
What are the side effects of Modipran?
Gastrointestinal: Fluoxetine Hydrochloride can cause nausea, vomiting, dyspepsia, dry mouth and diarrhoea. Neurological: Anxiety, nervousness, insomnia or drowsiness, and fatigue can occur.
Can I take Modipran during pregnancy or while breastfeeding?
Animal studies found no teratogenicity or other harmful effect with Fluoxetine. But animal reproductive studies don't always predict what happens in humans, so Fluoxetine should be used in pregnancy only if it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Modipran?
Keep Fluoxetine Hydrochloride away from light and moisture. Store it in a cool, dry place, below 30°C.
Can I take other medicines with Modipran?
Some medicines can interact with Fluoxetine Hydrochloride, for example: Haloperidol, Carbamazepine, Phenytoin, Clozapine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Nodepress by Kemiko Pharmaceuticals Ltd. has the same ingredient and strength for ৳2.60 per unit, compared with ৳2.89 for Modipran. Ask your doctor or pharmacist before switching.
Do I need a prescription for Modipran?
Modipran is a prescription (Rx) medicine. Take it as your doctor advises.