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These brands contain the same active ingredient (Misoprostol). Same strength and form. Confirm the switch with your doctor or pharmacist.
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Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Misoclear is indicated for:
Pharmacology
Misoprostol is extensively absorbed and rapidly de-esterified to its free acid, which is responsible for its clinical activity and, unlike the parent compound, can be detected in plasma. Peak plasma levels of misoprostol acid are lower when the dose is taken with food, and taking an antacid alongside it reduces the total amount of misoprostol acid available. Misoprostol has both antisecretory action, in that it inhibits gastric acid secretion, and, in animal studies, a protective effect on the stomach lining. NSAIDs inhibit prostaglandin synthesis, and a resulting shortage of prostaglandins in the gastric mucosa can reduce bicarbonate and mucus secretion, contributing to the mucosal damage these drugs cause. Misoprostol can boost bicarbonate and mucus production, but in humans this has only been shown at doses of 200 mcg and above, doses that are also antisecretory. It is therefore not possible to say whether misoprostol's ability to lower the risk of gastric ulcer comes from its antisecretory effect, its protective effect on the mucosa, or both.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily, given in 2 to 4 divided doses with breakfast or main meals and at bedtime. Treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required.
Prophylaxis of NSAID-induced gastric and duodenal ulcer: 200 mcg 2 to 4 times daily, taken with the NSAID. If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy as prescribed by the physician.
Induction of labor: Place 25 mcg in the posterior fornix of the vagina. Repeat every 6 hours if necessary until the maximum total dose of 200 mcg of misoprostol is reached. Fetal heart rate and uterine contractions should be monitored. Alternatively, 100 mcg may be taken orally. If cervical ripening or active labor does not occur, a repeated dose of 100 to 200 mcg of oral misoprostol is given every 4 hours until labor is established, as shown by a Bishop score of 7 or more. The maximum number of doses is 6. Maternal vital signs, fetal heart rate and contractions should be monitored. Oxytocin can be started 4 hours after the last dose of misoprostol. The physician should be notified of any signs of fetal distress or tetanic uterine contractions. Oral misoprostol therapy should be monitored by a physician.
Prevention of postpartum hemorrhage: 600 mcg orally immediately following delivery.
Treatment of postpartum hemorrhage: 600 mcg orally or 1000 mcg rectally.
Side Effects
Cytomis is generally well tolerated. The side effects most often reported with Cytomis treatment involve the GI tract (gastrointestinal system) and include diarrhea, abdominal pain, dyspepsia (indigestion), flatulence, nausea, vomiting, rashes and dizziness. Diarrhea can be kept to a minimum by taking the medicine after meals and at bedtime, and by not taking it together with a magnesium-containing antacid or any other antacid that has a laxative effect.
Cautions & Contraindications
Warnings & Precautions
When used to prevent or treat stomach and duodenal ulcers caused by NSAIDs: Cytomis is contraindicated in pregnant women and should not be used in women who are able to become pregnant unless they need NSAID therapy. Women who are able to become pregnant should be told that they must not be pregnant when Cytomis treatment is started, and that they must use an effective method of contraception while taking Cytomis. When used to induce labour: The pregnancy should have completed 38 weeks of gestation by reliable dating, or lung maturity should be shown by an L/S ratio above 2.0 or a positive phosphatidyl glycerol test, or the pregnancy should have completed 36 weeks of gestation with a maternal or fetal medical reason for inducing labour. Inducing labour is contraindicated in acute fetal distress, abruptio placenta, placenta previa, or unexplained vaginal bleeding. The fetus should be in vertex presentation.
Contraindications
Misoprostol should not be used by anyone with a known allergy to prostaglandins. It is also contraindicated in pregnancy.
Pregnancy & Breastfeeding
Misoprostol can cause abortion, so it must not be used by women who are pregnant. It should also not be given to women who could become pregnant, with one exception. That is when the patient needs nonsteroidal anti-inflammatory drug (NSAID) therapy and is at high risk of developing a gastric or duodenal ulcer, or of developing complications from such an ulcer linked to the NSAID. In these patients Misoprostol may be prescribed if the patient has had a negative serum pregnancy test within 2 weeks before starting therapy. The patient must also be able to comply with effective contraceptive measures, and she must have received both oral and written warnings about the hazards of Misoprostol, the risk that contraception may fail, and the danger to other women of childbearing potential if the drug is taken by mistake. Finally, she should begin it only on the second or third day of her next normal menstrual period.
The active metabolite (Misoprostol acid) may pass into breast milk, but this has not been studied. Because of the potential for serious adverse reactions in nursing infants, Misoprostol is not recommended for nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in children: Misoprostol hasn't been shown to be safe or effective in children below the age of 18 years.
Overdose
No one has worked out what dose of Misoprostol is toxic in humans. Signs that may point to an overdose are sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea and fever. Treatment is supportive, directed at the symptoms as they appear.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Misoprostol in a cool, dry place, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Misoclear 200 mcg
What is Misoclear 200 mcg Tablet?
Misoclear 200 mcg Tablet is a medicine that contains Misoprostol. It is made by The ACME Laboratories Ltd. It belongs to the Drugs acting on the Uterus group of medicines.
What is Misoclear used for?
Misoclear is used for: Peptic Ulcer.
What are the side effects of Misoclear?
Cytomis is generally well tolerated. The side effects most often reported with Cytomis treatment involve the GI tract (gastrointestinal system) and include diarrhea, abdominal pain, dyspepsia (indigestion), flatulence, nausea, vomiting, rashes and dizziness.
Can I take Misoclear during pregnancy or while breastfeeding?
Misoprostol can cause abortion, so it must not be used by women who are pregnant. It should also not be given to women who could become pregnant, with one exception. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Misoclear?
No one has worked out what dose of Misoprostol is toxic in humans. Signs that may point to an overdose are sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea and fever. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Misoclear?
Keep Misoprostol in a cool, dry place, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Misoclear?
Some medicines can interact with Misoprostol, for example: Polymyxin B Sulfate, Mifepristone + Misoprostol, Diclofenac Sodium + Misoprostol. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Misoclear?
Misoclear is a prescription (Rx) medicine. Take it as your doctor advises.