Indications & Uses
Pharmacology
Pizotifen reduces the peripheral effects of serotonin and histamine, both of which increase the permeability of cranial blood vessel membranes and the leakage of plasmakinin, and this action helps shift pain thresholds during a migraine. It also blocks 5-HT receptors, which lessens serotonin's role in constricting cranial blood vessels and its tendency to boost platelet activity and clumping. Some evidence suggests the drug curbs the peripheral effects of bradykinin as well. Pizotifen may also limit how much serotonin blood platelets reabsorb, a change that affects vessel tone and reduces the passive widening of extracranial arteries. As for its tendency to stimulate appetite, this is thought to arise from its influence on metabolism rather than any direct action on the brain's appetite centre.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: The usual dose is 1.5 mg daily, taken either as a single dose at night or split into three smaller doses through the day. The dose should be adjusted to suit each patient, up to a maximum of 4.5 mg daily. A single dose of up to 3 mg may be given.
Children (over 2 years of age): Up to 1.5 mg daily, usually given in divided doses, although up to 1 mg has been given as a single dose at night.
Side Effects
The most common side effects are increased appetite, weight gain and drowsiness.
Cautions & Contraindications
Warnings & Precautions
Take care in patients with urinary retention or kidney impairment. Pizotifen can cause drowsiness, which may impair the ability to drive or operate machinery. Pizotifen also enhances the effects of alcohol.
Contraindications
Pizotifen should not be used by anyone who has a known allergy (hypersensitivity) to pizotifen or to any other ingredient in the product.
Pregnancy & Breastfeeding
Pizotifen hasn't been studied extensively in pregnant women, though no harmful effects have come to light so far. Given this limited data, it should only be used during pregnancy if the expected benefit to the mother outweighs any possible risk to the unborn baby. Similarly, its safety while breastfeeding hasn't been established, so it's best avoided by nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Pizotifen in a dry place, away from light and heat. Keep it out of the reach of children.
Common questions about Migratin 500 mcg
What is Migratin 500 mcg Tablet?
Migratin 500 mcg Tablet is a medicine that contains Pizotifen. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Anti-histamine Preparations group of medicines.
What is Migratin used for?
Migratin is used for: Migraine, Headache.
What are the side effects of Migratin?
The most common side effects are increased appetite, weight gain and drowsiness.
Can I take Migratin during pregnancy or while breastfeeding?
Pizotifen hasn't been studied extensively in pregnant women, though no harmful effects have come to light so far. Given this limited data, it should only be used during pregnancy if the expected benefit to the mother outweighs any possible risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Migratin?
Store Pizotifen in a dry place, away from light and heat. Keep it out of the reach of children.
Do I need a prescription for Migratin?
Migratin is a prescription (Rx) medicine. Take it as your doctor advises.