Pricing
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All price changes →Indications & Uses
MIF is indicated as a medical alternative to surgical termination of intra-uterine pregnancy. It is also used for softening and dilatation of the cervix uteri before surgical pregnancy termination. Another use is preparation for the action of prostaglandin analogues when a pregnancy is terminated for medical reasons. And MIF is indicated for labour induction, to bring about the expulsion of a dead fetus (fetal death in utero).
Pharmacology
Mifepristone is an antiprogestin, meaning it blocks the action of progesterone, a naturally produced hormone that prepares the inner lining of the uterus for implantation of a fertilized ovum and support of a growing embryo and placenta. The drug is taken orally in a prescribed dose during the first seven to nine weeks of pregnancy, and within two days the uterine lining begins to deteriorate, usually causing bleeding similar to that experienced during normal menstruation. Mifepristone is then followed by a dose (taken orally or as a vaginal suppository) of the synthetic prostaglandin Misoprostol, which stimulates the uterus to undergo contractions. The embryo and other uterine contents are then expelled in a process very similar to spontaneous abortion or miscarriage.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
As a medical alternative to surgical termination of intra-uterine pregnancy in early pregnancy: a single oral dose of 600 mg Mifepristone is taken, followed 36 to 48 hours later by a prostaglandin analogue, either Misoprostol 400 mcg taken orally (for pregnancies up to 49 days) or Gemeprost 1 mg given vaginally (for pregnancies up to 63 days).
For softening and dilatation of the cervix uteri before surgical termination of pregnancy: 200 mg Mifepristone is given, followed 36 to 48 hours later (but not later than that) by the surgical termination of pregnancy.
As preparation for the action of prostaglandin analogues when terminating a pregnancy for medical reasons, in order to reduce the required doses of prostaglandin: a single oral dose of 600 mg Mifepristone is taken 36 to 48 hours before the scheduled prostaglandin administration, which is then repeated as often as needed.
For induction of labour to expel a dead fetus (fetal death in utero): 600 mg of Mifepristone is taken as a single oral dose, once daily, for 2 consecutive days. Mifepristone alone brings about expulsion in around 60% of cases. If labour has not begun within 72 hours of the first Mifepristone dose, it should be induced using the usual methods.
Use in children: safety and effectiveness in pediatric patients have not been established.
Side Effects
Uterine contractions or cramping are very common in the hours after taking the prostaglandin, affecting roughly 10 to 45% of women. Bleeding tends to be heavier with more advanced gestational age, with heavy bleeding occurring in about 5% of cases; of these, roughly 0 to 1.4% may need haemostatic curettage. Uterine rupture, low blood pressure, skin rashes, hives, hot flashes and dizziness have been reported uncommonly.
Cautions & Contraindications
Warnings & Precautions
Mifepristone (MIF) comes only in single-dose packaging and must be given under the supervision of a qualified physician. Its safety and effectiveness have not been studied in women with chronic conditions such as cardiovascular, hypertensive, hepatic, respiratory or renal disease; insulin-dependent diabetes mellitus; severe anemia; or heavy smoking. Women over 35 who smoke 10 or more cigarettes a day should be treated with caution, since such patients were generally excluded from MIF's clinical trials. No clinical evidence confirms it, but MIF may work less effectively if misoprostol is given more than two days after it.
Contraindications
Mifepristone should not be used if there is any uncertainty about whether the pregnancy exists or how far along it is, or if an ectopic (outside-the-womb) pregnancy is suspected. An ultrasound scan and/or a Beta-hCG measurement should be carried out before the medicine is given. For first-trimester abortion, Mifepristone is not recommended once the pregnancy has passed 49 days since the last menstrual period if it is being combined with Misoprostol, or 63 days if combined with Gemeprost. Mifepristone should never be given to patients with chronic adrenal failure, a known allergy to Mifepristone or any of its ingredients, severe asthma that is not controlled by corticosteroid treatment, porphyria, kidney or liver failure, malnutrition, or during breastfeeding. Mifepristone is a fat-soluble compound and may in theory pass into breast milk, though no data on this are currently available.
Pregnancy & Breastfeeding
Mifepristone is approved only for ending an early pregnancy, up to 49 days' gestation, and should not be used for any other purpose during pregnancy. Whether it passes into breast milk is not known, though many hormones with a similar structure do. Because its effects on a nursing infant are not established, breastfeeding mothers should talk to their doctor about whether to express and discard their milk for a few days after taking the medication.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Single doses of Mifepristone up to 2 gm caused no unwanted reaction. If someone takes a very large amount, signs of adrenal failure might appear. Acute intoxication may need admission to hospital and, if relevant, treatment with dexamethasone.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Mifepristone in a cool, dry place, away from light. The storage temperature should stay below 25°C.
Drug Interactions
Common questions about MIF 200 mg
What is MIF 200 mg Tablet?
MIF 200 mg Tablet is a medicine that contains Mifepristone. It is made by Renata PLC. It belongs to the Drugs acting on the Uterus group of medicines.
What is MIF used for?
MIF is indicated as a medical alternative to surgical termination of intra-uterine pregnancy. It is also used for softening and dilatation of the cervix uteri before surgical pregnancy termination.
What are the side effects of MIF?
Uterine contractions or cramping are very common in the hours after taking the prostaglandin, affecting roughly 10 to 45% of women. Bleeding tends to be heavier with more advanced gestational age, with heavy bleeding occurring in about 5% of cases; of these, roughly 0 to 1.4% may need haemostatic curettage.
Can I take MIF during pregnancy or while breastfeeding?
Mifepristone is approved only for ending an early pregnancy, up to 49 days' gestation, and should not be used for any other purpose during pregnancy. Whether it passes into breast milk is not known, though many hormones with a similar structure do. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much MIF?
Single doses of Mifepristone up to 2 gm caused no unwanted reaction. If someone takes a very large amount, signs of adrenal failure might appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store MIF?
Keep Mifepristone in a cool, dry place, away from light. The storage temperature should stay below 25°C.
Can I take other medicines with MIF?
Some medicines can interact with Mifepristone, for example: Ibuprofen, Ibuprofen + Paracetamol, Mifepristone + Misoprostol, Dexketoprofen, Erythromycin, Carbamazepine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
MIF is already among the lowest-priced brands of Mifepristone at this strength.
Do I need a prescription for MIF?
MIF is a prescription (Rx) medicine. Take it as your doctor advises.