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Indications & Uses
Midorest is indicated for:
Pharmacology
Benzodiazepines such as midazolam work by acting on gamma-aminobutyric acid (GABA), one of the main inhibitory neurotransmitters in the central nervous system. They increase the activity of GABA, which produces a calming, sedative effect, relaxes the skeletal muscles, and brings on sleep, anesthesia, and memory loss (amnesia). Midazolam does this by attaching to the benzodiazepine site on GABA-A receptors, which strengthens the effect of GABA by making chloride channels open more often. These receptors are found in various body tissues, including the heart and skeletal muscle, but they are concentrated mainly in the central nervous system.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral dosage. For adults, the usual dose is 7.5 to 15 mg daily. For elderly and debilitated patients, the recommended dose is 7.5 mg. For premedication, 15 mg of midazolam should be given 30 to 60 minutes before the procedure.
Intravenous administration. For endoscopic or cardiovascular procedures in healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg. For induction of anesthesia, the dose is 10 to 15 mg.
Intramuscular administration. For adults, the dose is 0.07 to 0.1 mg per kg of body weight, and the usual dose is about 5 mg. For children, the dose is 0.15 to 0.20 mg per kg. For elderly and debilitated patients, the dose is 0.025 to 0.05 mg per kg.
Rectal administration in children. For preoperative sedation, the ampoule solution is given rectally at 0.35 to 0.45 mg per kg, 20 to 30 minutes before induction of general anesthesia.
Side Effects
When treatment begins, daytime drowsiness, confusion, tiredness, headache and muscle weakness may occur; these usually settle as dosing continues. After parenteral (IV or IM) administration of Sedaquil, changes in vital signs have been reported, including respiratory depression, apnoea, and variations in blood pressure and pulse rate.
Cautions & Contraindications
Warnings & Precautions
Midazolam (Sedaquil IV) should be given very slowly.
Contraindications
Midazolam must not be used in patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, or sleep apnoea syndrome, or in those with known hypersensitivity to benzodiazepines or to any component of the product.
Pregnancy & Breastfeeding
Midazolam is generally avoided during pregnancy unless no safer option is available. It also passes into breast milk, so breastfeeding mothers should not take it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
A very large overdose of Midazolam can lead to coma, loss of reflexes (areflexia), depression of the heart and breathing, and apnea, which means breathing stops. The effects of an overdose can be controlled with flumazenil, a benzodiazepine antagonist.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Midazolam away from light and moisture, and store it in a cool, dry place. Keep it out of the reach of children.
Drug Interactions
Common questions about Midorest 15 mg
What is Midorest 15 mg Tablet?
Midorest 15 mg Tablet is a medicine that contains Midazolam. It is made by Benham Pharmaceuticals Ltd. It belongs to the Benzodiazepine hypnotics group of medicines.
What is Midorest used for?
Midorest is used for: Insomnia.
What are the side effects of Midorest?
When treatment begins, daytime drowsiness, confusion, tiredness, headache and muscle weakness may occur; these usually settle as dosing continues. After parenteral (IV or IM) administration of Sedaquil, changes in vital signs have been reported, including respiratory depression, apnoea, and variations in blood pressure and pulse rate.
Can I take Midorest during pregnancy or while breastfeeding?
Midazolam is generally avoided during pregnancy unless no safer option is available. It also passes into breast milk, so breastfeeding mothers should not take it. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Midorest?
A very large overdose of Midazolam can lead to coma, loss of reflexes (areflexia), depression of the heart and breathing, and apnea, which means breathing stops. The effects of an overdose can be controlled with flumazenil, a benzodiazepine antagonist. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Midorest?
Keep Midazolam away from light and moisture, and store it in a cool, dry place. Keep it out of the reach of children.
Can I take other medicines with Midorest?
Some medicines can interact with Midazolam, for example: Lercanidipine Hydrochloride, Itraconazole, Ceritinib, Lopinavir + Ritonavir, Armodafinil, Elagolix Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Midorest is already among the lowest-priced brands of Midazolam at this strength.
Do I need a prescription for Midorest?
Midorest is a prescription (Rx) medicine. Take it as your doctor advises.