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Same active ingredient — pay up to 21% less
These brands contain the same active ingredient (Diclofenac Sodium + Misoprostol). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Miclofenac
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Miclofenac is indicated for:
Pharmacology
It is a combination product containing Diclofenac Sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and Misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E1 analog. Like other NSAIDs, the exact mechanism of action of Diclofenac Sodium is not completely understood, but it may be related to inhibition of prostaglandin synthetase. NSAIDs inhibit prostaglandin synthesis, and a deficiency of prostaglandins within the gastric and duodenal mucosa may reduce bicarbonate and mucosal secretion, contributing to the mucosal damage caused by NSAIDs. Misoprostol helps counter this GI effect by increasing bicarbonate and mucous production, thereby helping to prevent gastric and duodenal ulcers.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Osteoarthritis: For the greatest protection of the GI (gastrointestinal) lining, the recommended dose is Diclofenac Sodium 50 mg with Misoprostol 200 µg three times daily. Patients who cannot tolerate this may take Diclofenac Sodium 75 mg with Misoprostol 200 µg twice daily, or Diclofenac Sodium 50 mg with Misoprostol 200 µg twice daily.
Rheumatoid arthritis: The recommended dose is Diclofenac Sodium 50 mg with Misoprostol 200 µg three or four times daily. Patients who cannot tolerate this may take Diclofenac Sodium 75 mg with Misoprostol 200 µg twice daily, or Diclofenac Sodium 50 mg with Misoprostol 200 µg twice daily.
Side Effects
The most commonly reported side effects are abdominal pain, diarrhoea and other GI (gastrointestinal) symptoms. Diarrhoea and abdominal pain tend to appear early in treatment and usually settle on their own within 2 to 7 days. In rare cases, patients taking Misoprostol have experienced severe diarrhoea leading to serious dehydration.
Cautions & Contraindications
Warnings & Precautions
If Diclofenac Sodium plus Misoprostol is prescribed, patients with an underlying condition such as inflammatory bowel disease, or those at risk of dehydration, should be monitored carefully.
Contraindications
Do not use this medicine if you are allergic to Diclofenac, Misoprostol or to other prostaglandins. It should also not be given to anyone who has had asthma, urticaria (hives) or other allergic-type reactions after taking aspirin or other NSAIDs.
Pregnancy & Breastfeeding
Because the Misoprostol component can cause miscarriage, this combination must not be used by women who are pregnant. Diclofenac Sodium does pass into breast milk, so Diclofenac Sodium plus Misoprostol is not advised for mothers who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Paediatric use
The safety and effectiveness of the Diclofenac Sodium and Misoprostol combination haven't been established in paediatric patients.
Geriatric use
Studies found no overall differences in safety or effectiveness between elderly and younger subjects, and other reported clinical experience hasn't found different responses between the two groups either. Still, a greater sensitivity in some elderly people can't be ruled out. As with any NSAID, the elderly are likely to tolerate adverse events less well than younger patients.
Overdose
Misoprostol overdose can cause convulsions, sedation, tremor, dyspnoea, diarrhoea, abdominal pain, fever, palpitations, hypotension and bradycardia. Management is supportive treatment.
Diclofenac overdose can cause lethargy, drowsiness, nausea, vomiting, epigastric pain and GI bleeding. Less often, HTN, acute renal failure, respiratory depression, anaphylactoid reactions and coma may occur.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep it in a cool, dry place below 25º C, and protect it from light.
Drug Interactions
Common questions about Miclofenac 50 mg+200 mcg
What is Miclofenac 50 mg+200 mcg Tablet?
Miclofenac 50 mg+200 mcg Tablet is a medicine that contains Diclofenac Sodium + Misoprostol. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Drugs for Osteoarthritis group of medicines.
What is Miclofenac used for?
Miclofenac is used for: Osteoarthritis, Rheumatoid Arthritis.
What are the side effects of Miclofenac?
The most commonly reported side effects are abdominal pain, diarrhoea and other GI (gastrointestinal) symptoms. Diarrhoea and abdominal pain tend to appear early in treatment and usually settle on their own within 2 to 7 days.
Can I take Miclofenac during pregnancy or while breastfeeding?
Because the Misoprostol component can cause miscarriage, this combination must not be used by women who are pregnant. Diclofenac Sodium does pass into breast milk, so Diclofenac Sodium plus Misoprostol is not advised for mothers who are breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Miclofenac?
Misoprostol overdose can cause convulsions, sedation, tremor, dyspnoea, diarrhoea, abdominal pain, fever, palpitations, hypotension and bradycardia. Management is supportive treatment. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Miclofenac?
Keep it in a cool, dry place below 25º C, and protect it from light.
Can I take other medicines with Miclofenac?
Some medicines can interact with Diclofenac Sodium + Misoprostol, for example: Diclofenac Sodium, Aspirin, Diclofenac, Warfarin Sodium, Misoprostol, Digoxin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Mifenac by Rephco Pharmaceuticals Ltd. has the same ingredient and strength for ৳8.00 per unit, compared with ৳10.07 for Miclofenac. Ask your doctor or pharmacist before switching.
Do I need a prescription for Miclofenac?
Miclofenac is a prescription (Rx) medicine. Take it as your doctor advises.