Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 22% less
These brands contain the same active ingredient (Metformin Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Metsa XR
Other strengths and forms by Synovia Pharma PLC.
Indications & Uses
Metsa XR is indicated for:
Pharmacology
Metformin is a biguanide type oral antihyperglycemic drug used to manage type 2 diabetes. It lowers both basal and postprandial plasma glucose levels. Its mechanism of action differs from that of sulfonylureas, and it does not cause hypoglycemia. Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
the Metformin XR tablet should be swallowed whole and should never be crushed, cut or chewed. For adults, the usual starting dose of Metformin XR is 500 mg once a day, taken with the evening meal. The dose should be increased in steps of 500 mg every week, up to a maximum of 2000 mg once a day taken with the evening meal, or alternatively increased to 1000 mg twice a day taken with meals. A patient who is already taking Metformin immediate release tablets may be switched to Metformin extended release tablets, up to the maximum recommended daily dose. Metformin extended release tablets have not been studied in children.
For patients with impaired kidney function, Metformin should not be used if the eGFR is below 30 mL/min/1.73 m2. The risks and benefits of continuing treatment should be assessed if the eGFR falls below 45 mL/min/1.73 m2.
Dosage for other forms (1)
the dose of Metformin Hydrochloride must be individualized based on how well it controls blood sugar and how well it is tolerated, and the maximum recommended daily doses should not be exceeded. For adults, the usual starting dose of Metformin is 500 mg twice a day or 850 mg once a day, taken with meals. The dose can then be increased in steps of 500 mg every week or 850 mg every 2 weeks, up to a total of 2000 mg a day, taken in divided doses. Patients who need additional glycemic control may be given Glucomin up to a maximum daily dose of 2550 mg a day. Doses above 2000 mg a day may be tolerated better if split into three doses a day taken with meals. For children, the usual starting dose of Metformin is 500 mg twice a day, taken with meals, and the dose can be increased in steps of 500 mg every week up to a maximum of 2000 mg a day, given in divided doses.
Side Effects
Blood and lymphatic system disorders: Not known: Hemolytic anemia. Metabolism and nutrition disorders: Very rare: Lactic acidosis. Long-term use of metformin can lower vitamin B12 absorption and reduce its serum levels; this should be considered if a patient develops megaloblastic anemia. Cases of peripheral neuropathy in patients with vitamin B12 deficiency have been reported after the medicine reached the market (frequency not known). Nervous system disorders: Common: Taste disturbance. Not known: Encephalopathy. Gastrointestinal disorders: Very common: Gastrointestinal effects such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These effects occur most often when treatment is first started and usually go away on their own. To help prevent them, metformin should be taken in 2 or 3 doses a day, during or after meals, and raising the dose slowly can also help the stomach tolerate it better. Hepatobiliary disorders: Very rare: Isolated reports of abnormal liver function tests or hepatitis that resolved once metformin was stopped. Skin and subcutaneous tissue disorders: Very rare: Skin reactions such as redness, itching, and hives.
Cautions & Contraindications
Warnings & Precautions
Glunor OD is largely cleared from the body by the kidneys, and the risk of Glunor OD buildup and lactic acidosis rises as kidney function declines. Glunor OD may lower vitamin B12 levels, and it also raises the risk of hypoglycaemia when used together with insulin or an insulin secretagogue. Because Glunor OD is excreted by the kidneys, regular monitoring of renal function is advised for all diabetic patients. Glunor OD therapy should be stopped 2 to 3 days before surgery and before clinical investigations such as intravenous urography and intravenous angiography, and should only be restarted once renal function has been confirmed to be normal or has recovered. Glunor OD is not advised in conditions that may cause dehydration or in patients with serious infections or trauma. Patients on continuous Glunor OD therapy should have their vitamin B12 levels checked annually, since there have been reports of reduced vitamin B12 absorption. When Glunor OD is taken together with a sulphonylurea, blood glucose should be monitored, as the combination may cause hypoglycaemia. Stabilizing diabetic patients on both Glunor OD and insulin should be done in a hospital setting, given the risk of hypoglycaemia until the right balance between the two medicines has been established. Reduced renal clearance of Glunor OD has been reported during cimetidine therapy, so a dose reduction should be considered. As with a number of medicines, an interaction between Glunor OD and anticoagulants is possible, and the anticoagulant dose may need to be adjusted.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Any type of acute metabolic acidosis, including lactic acidosis and diabetic ketoacidosis. Severe renal failure, with GFR below 30 mL/min. Acute conditions that could affect kidney function, such as dehydration, severe infection, or shock. Any acute or chronic disease that may cause tissue hypoxia, including cardiac or respiratory failure, a recent heart attack, or shock. Hepatic insufficiency, acute alcohol intoxication, and alcoholism.
Pregnancy & Breastfeeding
Pregnancy: Uncontrolled diabetes during pregnancy, whether gestational or pre-existing, raises the risk of birth defects and death around the time of birth. For women planning a pregnancy and for those who are already pregnant, diabetes should be managed with insulin rather than metformin, keeping blood glucose levels as close to normal as possible to lower the risk of harm to the baby.
Breastfeeding: Metformin passes into human breast milk. No harmful effects have been seen in breastfed newborns or infants, but because the available data are limited, breastfeeding is not recommended while taking metformin. The decision to stop breastfeeding should weigh the benefits of breastfeeding against the potential risk of side effects in the child.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Elderly: Kidney function may be lower in elderly people, so the metformin dose should be adjusted according to renal function. Renal function needs to be assessed regularly.
Pediatric population: The diagnosis of type 2 diabetes mellitus should be confirmed before metformin is started. Controlled clinical studies lasting one year found no effect of metformin on growth and puberty, but there are no long-term data on these points. For this reason, children treated with metformin, especially prepubescent children, should be followed up carefully for any effect on growth and puberty.
Children aged between 10 and 12 years: Take particular care when prescribing to children in this age group.
Renal function: Metformin is excreted by the kidney, so creatinine clearance should be determined before treatment starts and regularly after that (it can be estimated from serum creatinine levels using the Cockcroft-Gault formula). Check it at least annually in patients with normal renal function, and at least two to four times a year in patients whose creatinine clearance is at the lower limit of normal and in elderly people. Decreased renal function is frequent in elderly people and gives no symptoms. Take special care in situations where renal function may become impaired, for example when antihypertensive therapy or diuretic therapy is started, and when a non-steroidal anti-inflammatory drug (NSAID) is started. GFR should be assessed before treatment begins and regularly after that. Metformin is contraindicated in patients with GFR<30 ml/min, and it should be stopped temporarily if any condition alters renal function.
Overdose
Doses of Metform up to 85 gm have not caused hypoglycemia, but lactic acidosis has occurred at these doses. Lactic acidosis is a medical emergency, so it must be treated in hospital. Hemodialysis is the most effective way to remove both lactate and Metform.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Metformin Hydrochloride below 30°C and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Metsa XR 1000 mg
What is Metsa XR 1000 mg Tablet (Extended Release)?
Metsa XR 1000 mg Tablet (Extended Release) is a medicine that contains Metformin Hydrochloride. It is made by Synovia Pharma PLC. It belongs to the Biguanides group of medicines.
What is Metsa XR used for?
Metsa XR is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Metsa XR?
Blood and lymphatic system disorders: Not known: Hemolytic anemia. Metabolism and nutrition disorders: Very rare: Lactic acidosis.
Can I take Metsa XR during pregnancy or while breastfeeding?
Pregnancy: Uncontrolled diabetes during pregnancy, whether gestational or pre-existing, raises the risk of birth defects and death around the time of birth. For women planning a pregnancy and for those who are already pregnant, diabetes should be managed with insulin rather than metformin, keeping blood glucose levels as close to normal as possible to lower the risk of harm to the baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Metsa XR?
Doses of Metform up to 85 gm have not caused hypoglycemia, but lactic acidosis has occurred at these doses. Lactic acidosis is a medical emergency, so it must be treated in hospital. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Metsa XR?
Store Metformin Hydrochloride below 30°C and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Metsa XR?
Some medicines can interact with Metformin Hydrochloride, for example: Nifedipine, Isoniazid, Digoxin, Vancomycin, Cimetidine, Trimethoprim. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Formet XR by Biopharma Ltd. has the same ingredient and strength for ৳7.00 per unit, compared with ৳9.00 for Metsa XR. Ask your doctor or pharmacist before switching.
Do I need a prescription for Metsa XR?
Metsa XR is a prescription (Rx) medicine. Take it as your doctor advises.