Pricing
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All price changes →Indications & Uses
Mefoglip DS is indicated for:
Pharmacology
Metformin belongs to the biguanide class of antihyperglycemic medicines. It improves glucose tolerance in people with type 2 diabetes by lowering both fasting and after-meal blood glucose levels, working through mechanisms that differ from those of other oral antihyperglycemic drug classes. Metformin reduces glucose production by the liver, lowers glucose absorption from the intestine, and improves the body's sensitivity to insulin, allowing tissues to take up and use glucose more effectively. Unlike sulfonylureas, metformin does not cause hypoglycemia in patients with type 2 diabetes or in people without diabetes, and it does not raise insulin levels in the blood.
Glipizide is a sulfonylurea that lowers blood glucose mainly by stimulating the pancreas to release insulin, an action that depends on functioning beta cells in the pancreatic islets. Effects outside the pancreas may also contribute to how sulfonylurea drugs work.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Glipizide & Metformin is usually taken once or twice a day with meals, starting at a low dose that is increased gradually as needed.
For patients starting on Glipizide & Metformin as initial therapy, the usual starting dose is 250 mg/2.5 mg once daily with a meal.
For patients switching to Glipizide & Metformin as second-line therapy, the usual starting dose is 500 mg/2.5 mg or 500 mg/5 mg twice daily, taken with the morning and evening meals.
The daily dose should not exceed 2000 mg of Metformin and 20 mg of Glipizide.
Side Effects
Glipizide & Metformin most commonly cause hypoglycemia (low blood sugar), diarrhea, nausea/vomiting, abdominal pain, headache, and musculoskeletal pain, among others.
Cautions & Contraindications
Warnings & Precautions
Metformin is largely cleared by the kidneys, so the risk of it building up in the body and causing lactic acidosis rises as kidney function declines. For this reason, patients whose serum creatinine is above the normal upper limit should not be given Metformin. Because kidney function tends to decline with age, older patients need their Metformin dose carefully titrated to find the lowest amount that still controls blood glucose adequately. Metformin should be stopped temporarily before any surgical procedure, and should not be restarted until the patient is eating normally again and kidney function has been confirmed to be normal. When Metformin is used together with a sulfonylurea, blood glucose levels should be monitored closely. If Metformin is combined with insulin therapy, this should be managed in a hospital setting until the right balance between the two medicines has been worked out. In patients with reduced kidney or liver function, Glipizide may be broken down and cleared from the body more slowly. Should hypoglycemia occur in these patients, it may last longer than usual, and it should be managed appropriately.
Contraindications
Renal impairment, diabetic coma and ketoacidosis, chronic kidney disease, congestive heart failure, trauma, dehydration, alcohol dependence, pregnancy, and breast-feeding are contraindications, as is known hypersensitivity to the drug.
Pregnancy & Breastfeeding
Contraindicated in pregnancy and during lactation
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Glipizide + Metformin Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Mefoglip DS 5 mg+500 mg
What is Mefoglip DS 5 mg+500 mg Tablet?
Mefoglip DS 5 mg+500 mg Tablet is a medicine that contains Glipizide + Metformin Hydrochloride. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Combination Oral hypoglycemic preparations group of medicines.
What is Mefoglip DS used for?
Mefoglip DS is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Mefoglip DS?
Glipizide & Metformin most commonly cause hypoglycemia (low blood sugar), diarrhea, nausea/vomiting, abdominal pain, headache, and musculoskeletal pain, among others.
Can I take Mefoglip DS during pregnancy or while breastfeeding?
Contraindicated in pregnancy and during lactation Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Mefoglip DS?
Store Glipizide + Metformin Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Mefoglip DS?
Some medicines can interact with Glipizide + Metformin Hydrochloride, for example: Nifedipine, Chloramphenicol, Cimetidine, Metformin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Mefoglip DS is already among the lowest-priced brands of Glipizide + Metformin Hydrochloride at this strength.
Do I need a prescription for Mefoglip DS?
Mefoglip DS is a prescription (Rx) medicine. Take it as your doctor advises.