Pricing
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All price changes →Indications & Uses
Medrina is indicated for:
Pharmacology
Pharmacodynamics: When given by intramuscular injection, Medroxyprogesterone Acetate provides a progestational effect that lasts for an extended period. It works by suppressing the pituitary gland's secretion of gonadotropins, which in turn prevents follicular maturation, producing long-term anovulation in women of reproductive age. In men, Medroxyprogesterone Acetate injection suppresses Leydig cell function, meaning it suppresses the body's own production of testosterone.
Pharmacokinetics: Given by injection, Medroxyprogesterone Acetate is a long-acting progestational steroid. The 150 mg/ml formulation takes about 27 days to fall to half its initial concentration. Its long duration of action comes from how slowly it is absorbed from the injection site. The main metabolite that has been identified is 6-alpha-methyl-6 beta 17 alpha, 21 trihydroxy-4-pregnene-3, 20-dione-17 acetate, which is excreted in the urine.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Ovulation suppression: Shake the Medroxyprogesterone Acetate injectable suspension gently just before use so that the dose given is a uniform suspension. The recommended dose is 150 mg/ml of this injectable suspension every three months, given by intramuscular injection into the gluteal or deltoid muscle. The first injection should be given during the first 5 days after the start of a menstrual period; within 5 days after delivery if not breastfeeding; or at or after six weeks after delivery if exclusively breastfeeding. Based on limited experience, some investigators prefer giving a second injection of Medroxyprogesterone Acetate before 90 days to control troublesome bleeding. The third and later injections should be given at separate 90-day intervals. If abnormal bleeding continues, appropriate investigations should be carried out to rule out the possibility of organic disease. Uterine curettage may be needed on rare occasions.
Side Effects
Weight gain, a feeling of heaviness and pain in the abdomen, pain, and anxiety may occur. Amenorrhea, spotting, or excessive bleeding can happen. There may be infection at the injection site, headache, blurring of vision, and pain in the back of the leg. Pregnancy may be delayed after stopping the injectable contraceptive.
Cautions & Contraindications
Warnings & Precautions
Caution is needed if unexpected vaginal bleeding occurs during therapy, in patients with a pre-existing medical condition that might be adversely affected by fluid retention, in patients with a history of treatment for clinical depression, and in diabetic patients. Medroxyprogesterone acetate may decrease the levels of certain endocrine biomarkers, including plasma or urinary steroids (such as cortisol, oestrogen, pregnanediol, progesterone and testosterone), plasma or urinary gonadotrophins (such as LH and FSH), and sex hormone-binding globulin (SHBG).
Contraindications
Medroxyprogesterone Acetate should not be used in known or suspected pregnancy, or when there is undiagnosed vaginal bleeding. It is also not for people with known or suspected malignancy of the breast (when used for ovulation suppression or gynaecology indications), or with severe liver dysfunction. Anyone with known hypersensitivity to medroxyprogesterone acetate or any component of the drug must not take it either.
Pregnancy & Breastfeeding
Not recommended during the first 4 months of pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Medroxyprogesterone Acetate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Medrina 5 mg
What is Medrina 5 mg Tablet?
Medrina 5 mg Tablet is a medicine that contains Medroxyprogesterone Acetate. It is made by Beacon Pharmaceuticals PLC. It belongs to the Female Sex hormones group of medicines.
What is Medrina used for?
Medrina is used for: Cancer.
What are the side effects of Medrina?
Weight gain, a feeling of heaviness and pain in the abdomen, pain, and anxiety may occur. Amenorrhea, spotting, or excessive bleeding can happen.
Can I take Medrina during pregnancy or while breastfeeding?
Not recommended during the first 4 months of pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Medrina?
Store Medroxyprogesterone Acetate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Medrina is already among the lowest-priced brands of Medroxyprogesterone Acetate at this strength.
Do I need a prescription for Medrina?
Medrina is a prescription (Rx) medicine. Take it as your doctor advises.