Indications & Uses
Mecobal is indicated for:
Pharmacology
Mecobalamin is one of the two active forms of vitamin B12 in the body. Unlike cyanocobalamin, it carries a methyl group in place of the cyano group attached to its cobalt atom. It acts as a cofactor for the enzyme methionine synthase, which transfers methyl groups to convert homocysteine back into methionine. This function makes it essential for maintaining the myelin sheath, supporting normal nerve activity, forming red blood cells properly, and synthesizing DNA. Mecobalamin also supports the production of lipids needed by nerve cells, aids in regenerating axonal nerves, promotes axonal transport, and provides protective effects for the nervous system.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For peripheral neuropathies, adults receive 1 ampoule (Mecobalamin 500 mcg) per dose, given by IM or IV injection three times a week. The dose may be adjusted depending on the patient's age and symptoms. For megaloblastic anemia, adults receive 1 ampoule (Mecobalamin 500 mcg) per dose, given by IM or IV injection three times a week. After 2 months of treatment, the dose should be reduced to a single 1 ampoule injection every 1 to 3 months as maintenance therapy.
Use in children: Not recommended.
Dosage for other forms (1)
Take one 0.5 mg tablet three times a day after meals. The dose should be adjusted according to the patient's age and the severity of the symptoms.
Side Effects
Dermatologic effects: Rash. If this occurs, treatment should be discontinued. Gastrointestinal effects: Anorexia (loss of appetite), nausea or vomiting, and diarrhea. Neurologic effects (central nervous system): Headache. Others: Anaphylactoid reaction, such as a decrease in blood pressure or dyspnea (difficulty breathing), may occur. Patients should be carefully observed. If these symptoms appear, treatment should be discontinued immediately and appropriate measures taken. Other reported effects include a hot sensation, diaphoresis (excessive sweating), and pain or induration (hardening) at the site of intramuscular injection.
Cautions & Contraindications
Warnings & Precautions
Mecomin should not be continued aimlessly for longer than one month unless it is clearly working. Prolonged use of higher doses of Mecomin is not advised for people whose work involves handling mercury or mercury compounds.
Contraindications
Known allergy to mecobalamin or any other ingredient in the product.
Pregnancy & Breastfeeding
There is no data on how mecobalamin behaves in pregnant women or in mothers who are breastfeeding. Even so, vitamin B12 passes into breast milk, and the American Academy of Pediatrics regards its use as usually compatible with breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Mecobalamin at room temperature, and keep it away from moisture and light.
Drug Interactions
Common questions about Mecobal 5 mg/ml
What is Mecobal 5 mg/ml Injection?
Mecobal 5 mg/ml Injection is a medicine that contains Mecobalamin. It is made by General Pharmaceuticals Ltd, Unit-2. It belongs to the Drugs for Megaloblastic Anemia group of medicines.
What is Mecobal used for?
Mecobal is used for: Neuropathic Pain, Parkinson's Disease, Anemia.
What are the side effects of Mecobal?
Dermatologic effects: Rash. If this occurs, treatment should be discontinued.
Can I take Mecobal during pregnancy or while breastfeeding?
There is no data on how mecobalamin behaves in pregnant women or in mothers who are breastfeeding. Even so, vitamin B12 passes into breast milk, and the American Academy of Pediatrics regards its use as usually compatible with breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Mecobal?
Keep Mecobalamin at room temperature, and keep it away from moisture and light.
Can I take other medicines with Mecobal?
Some medicines can interact with Mecobalamin, for example: Omeprazole, Colchicine, Neomycin Sulphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Mecobal?
Mecobal is a prescription (Rx) medicine. Take it as your doctor advises.