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Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Lubistone is indicated for:
Pharmacology
Lubiprostone is a locally acting chloride channel activator. It boosts the secretion of chloride-rich fluid into the intestine without changing sodium or potassium levels in the blood. It works by specifically activating ClC-2, a channel normally present in the apical membrane of the human intestinal lining. This rise in intestinal fluid secretion increases intestinal motility, which helps stool pass more easily and eases the symptoms of constipation. After a dose, lubiprostone and its metabolites are found only on the apical (luminal) side of the gastrointestinal lining. Its activation of ClC-2 also helps restore mucosal barrier function by rebuilding tight junction protein complexes. Symptom relief is typically felt within 24 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Chronic idiopathic constipation: 24 mcg taken by mouth twice daily with food and water.
Opioid-induced constipation: 24 mcg taken by mouth twice daily with food and water.
Irritable bowel syndrome with constipation: 8 mcg taken by mouth twice daily with food and water.
Side Effects
Possible side effects include nausea, vomiting, loose stools, dry mouth, stomach discomfort, headache and dizziness, among others.
Cautions & Contraindications
Warnings & Precautions
Nausea: Some people taking Lubigut may feel nauseous. If this happens, taking Lubigut together with food may help reduce the nausea. Diarrhea: Lubigut should not be prescribed to people who have severe diarrhea. Bowel obstruction: In people whose symptoms suggest a mechanical blockage of the gut, confirm that no such obstruction is present before starting treatment with Lubigut.
Contraindications
Lubiprostone should not be used in patients who have, or are suspected to have, a mechanical blockage of the gut (gastrointestinal obstruction).
Pregnancy & Breastfeeding
Pregnancy Category C. Lubiprostone should only be used during pregnancy if the potential benefit to the mother is judged to outweigh the possible risk to the unborn baby. It is not known whether Lubiprostone passes into human breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children and adolescents: Lubiprostone has not been studied for safety or effectiveness in children and adolescents.
Geriatric use: In Irritable Bowel Syndrome with Constipation, the safety and efficacy of Lubiprostone in elderly patients (over 65 years of age) remains the same as in younger patients.
Renal impairment: Lubiprostone has not been studied in patients with renal impairment.
Hepatic impairment: The dose should be reduced in patients with moderate and severe hepatic impairment.
Overdose
If someone takes too much Lubiprostone, the reactions to expect are nausea, diarrhea, vomiting, dizziness, headache and abdominal pain.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Lubiprostone out of the reach of children. Store it in a cool, dry place below 25°C and protect it from light.
Common questions about Lubistone 24 mcg
What is Lubistone 24 mcg Capsule?
Lubistone 24 mcg Capsule is a medicine that contains Lubiprostone. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other laxative preparations group of medicines.
What is Lubistone used for?
Lubistone is used for: Constipation, Irritable Bowel Syndrome.
What are the side effects of Lubistone?
Possible side effects include nausea, vomiting, loose stools, dry mouth, stomach discomfort, headache and dizziness, among others.
Can I take Lubistone during pregnancy or while breastfeeding?
Pregnancy Category C. Lubiprostone should only be used during pregnancy if the potential benefit to the mother is judged to outweigh the possible risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lubistone?
If someone takes too much Lubiprostone, the reactions to expect are nausea, diarrhea, vomiting, dizziness, headache and abdominal pain. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lubistone?
Keep Lubiprostone out of the reach of children. Store it in a cool, dry place below 25°C and protect it from light.
Is there a cheaper medicine with the same ingredient?
Lubistone is already among the lowest-priced brands of Lubiprostone at this strength.
Do I need a prescription for Lubistone?
Lubistone is a prescription (Rx) medicine. Take it as your doctor advises.