Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Loteflam G is indicated for:
Pharmacology
Loteprednol etabonate and other corticosteroids are thought to act by inducing phospholipase A2 inhibitory proteins, which are collectively called lipocortins. These proteins are believed to control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. They do this by stopping the release of arachidonic acid, the common precursor of both. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Gatifloxacin is an 8-methoxyfluoroquinolone with a 3-methylpiperazinyl substituent at C7. It kills bacteria by inhibiting DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is known to play a key part in separating the chromosomal DNA when a bacterial cell divides.
Fluoroquinolones, gatifloxacin included, work differently from aminoglycoside, macrolide and tetracycline antibiotics. So gatifloxacin may be active against pathogens that are resistant to those antibiotics, and those antibiotics may be active against pathogens that are resistant to gatifloxacin.
Gatifloxacin has been shown to be active against most isolates of the following organisms, both microbiologically and clinically.
Aerobic Gram-Positive Bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae.
Aerobic Gram-Negative Bacteria: Haemophilus influenza.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Put one or two drops of the sterile ophthalmic suspension into the conjunctival sac of the affected eye or eyes, every four to six hours. In the first 24 to 48 hours the doctor may increase this to every one to two hours. As the signs of the eye problem improve, bring the frequency down gradually. Take care not to stop the treatment too early.
Side Effects
Side effects can come from the steroid part, the anti-infective part, or the two together in steroid and anti-infective combination medicines like loteprednol etabonate with gatifloxacin. The reactions linked with ophthalmic steroids include raised IOP, which may occasionally go with optic nerve damage and defects in visual acuity and visual field. Other reactions are posterior sub capsular cataract formation and delayed wound healing. Secondary eye infections can also develop from pathogens including herpes simplex, and the globe may perforate where the cornea or sclera has thinned. For gatifloxacin, the most frequently reported adverse effects in the overall study population were conjunctival irritation, increased lacrimation, keratitis and papillary conjunctivitis. These occurred in approximately 5 to 10% of patients. Other reactions, seen in 1 to 4% of patients, were chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye irritation, eye pain, eyelid edema, headache, red eye, reduced visual acuity and taste disturbance. Redness was the most commonly observed adverse event, at 6%. Itching, discharge, photophobia and blurred vision were seen in less than 2% of cases.
Cautions & Contraindications
Warnings & Precautions
Don't inject this preparation under the conjunctiva, and don't put it directly into the anterior chamber of the eye. If Loteprednol Etabonate + Gatifloxacin is used for 10 days or longer, the intraocular pressure should be monitored. Where a corneal ulcer persists and a steroid has been or is still being used, think of a fungal invasion. If redness or itching gets worse, the patient should be told to see a physician. Patients who wear soft contact lenses and whose eyes are not red should be told to wait at least ten minutes after instilling it before they put their lenses in.
Contraindications
Don't use this sterile eye suspension of Loteprednol Etabonate + Gatifloxacin if you have most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex. It is also not for mycobacterial infection of the eye, or for fungal diseases of the ocular structures. The suspension must not be used by anyone who is known to be hypersensitive to any of its ingredients. The same applies to patients with a history of hypersensitivity to other quinolones, acetylsalicylic acid and other non-steroidal anti-inflammatory medicines.
Pregnancy & Breastfeeding
Loteprednol Etabonate + Gatifloxacin is Pregnancy Category C. No adequate and well-controlled studies have been done in pregnant women, so it should be used in pregnancy only if the likely benefit justifies the possible risk to the fetus.
It is not known whether this medicine passes into human milk. Many drugs do pass into milk, so caution is needed when Loteprednol Etabonate + Gatifloxacin is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep the Loteprednol Etabonate + Gatifloxacin bottle at room temperature and away from light. Don't let the dropper tip touch any surface. It's best not to use the contents more than one month after the bottle is first opened. Don't let it freeze.
Common questions about Loteflam G 0.5%+0.3%
What is Loteflam G 0.5%+0.3% Ophthalmic Suspension?
Loteflam G 0.5%+0.3% Ophthalmic Suspension is a medicine that contains Loteprednol Etabonate + Gatifloxacin. It is made by General Pharmaceuticals Ltd. It belongs to the Ophthalmic Steroid preparations group of medicines.
What is Loteflam G used for?
Loteflam G is used for: Viral Infection, Acne Vulgaris, Conjunctivitis, Inflammation.
What are the side effects of Loteflam G?
Side effects can come from the steroid part, the anti-infective part, or the two together in steroid and anti-infective combination medicines like loteprednol etabonate with gatifloxacin. The reactions linked with ophthalmic steroids include raised IOP, which may occasionally go with optic nerve damage and defects in visual acuity and visual field.
Can I take Loteflam G during pregnancy or while breastfeeding?
Loteprednol Etabonate + Gatifloxacin is Pregnancy Category C. No adequate and well-controlled studies have been done in pregnant women, so it should be used in pregnancy only if the likely benefit justifies the possible risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Loteflam G?
Keep the Loteprednol Etabonate + Gatifloxacin bottle at room temperature and away from light. Don't let the dropper tip touch any surface.
Do I need a prescription for Loteflam G?
Loteflam G is a prescription (Rx) medicine. Take it as your doctor advises.