More from Loraxen
Other strengths and forms by Techno Drugs Ltd., Satipara, Narshingdi
Indications & Uses
Loraxen is indicated for:
Pharmacology
Lorazepam is a short-acting tranquilizer from the benzodiazepine group. It works as an agonist at benzodiazepine receptors in the central nervous system (CNS). Its depressant effect on the CNS may come from strengthening the inhibitory action of GABA (gamma amino butyric acid) in the CNS. This in turn reduces the activity of the ascending activating systems, particularly the serotonergic and noradrenergic pathways that run from the brain stem or mid-brain up to the cerebral cortex.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Lorazepam is taken by mouth. For best results, the dose, how often it is taken, and how long treatment continues should be tailored to each patient's response. The usual range is 2 to 6 mg a day in divided doses, with the largest dose taken at bedtime, though the largest single dose may range from 1 to 10 mg a day. For anxiety, most patients need an initial dose of 2 to 3 mg a day, taken twice or three times daily. For elderly or frail patients, an initial dose of 1 to 2 mg a day in divided doses is recommended, adjusted as needed and tolerated. For insomnia, 1 to 2 mg is taken before bedtime; as a premedicant, 1 to 2 mg is given the night before surgery and again 1 to 2 hours before surgery.
Lorazepam injection can be given intravenously or intramuscularly. For premedication in adults: 0.05 mg/kg (3.5 mg for an average 70 kg person), given by IV 30 to 45 minutes before the procedure, or by IM 60 to 90 minutes before. For acute anxiety in adults: 0.025 to 0.03 mg/kg (1.75 to 2.1 mg for an average 70 kg person), repeated every 6 hours. For status epilepticus in adults: 4 mg intravenously; in children: 2 mg intravenously.
For intramuscular use, undiluted lorazepam injection should be given. For intravenous use, it must be diluted with an equal volume of a compatible solution, such as sterile water for injection, sodium chloride injection, or 5% dextrose injection. The rate of injection should not exceed 2 mg per minute.
Side Effects
Adverse effects with Lorapam tend to show up early in treatment and usually ease off as the body adjusts or once the dose is reduced. The most common issue is sedation, along with dizziness, weakness and unsteadiness on the feet. Less often, patients notice disorientation, low mood, nausea, changes in appetite, headache, disturbed sleep, or agitation. Skin reactions and vision-related disturbances can also occur, as can a range of gastrointestinal complaints and other autonomic effects.
Cautions & Contraindications
Warnings & Precautions
Cautions & Precautions In patients whose depression occurs alongside anxiety, the possibility of suicide should be kept in mind. Elderly or debilitated patients should start with no more than 2 mg a day, as higher doses can lead to over-sedation. The usual precautions taken when treating patients with impaired kidney or liver function, or with acute or chronic lung insufficiency, should be followed. Lorapam should be used with caution over extended periods in patients with gastric conditions, and such patients should be monitored regularly for signs of upper gastrointestinal disease. Patients should avoid operating machinery while taking Lorapam.
Contraindications
Lorazepam should not be used in patients who have shown previous sensitivity to benzodiazepines, nor in those with acute narrow-angle glaucoma or myasthenia gravis.
Pregnancy & Breastfeeding
Safety of Lorazepam during pregnancy has not been established. Since treatment with this medicine is rarely urgent, it should almost always be avoided during this period.
It is not known whether oral Lorazepam passes into breast milk, as other benzodiazepine sedatives do. As a general precaution, breastfeeding should be avoided while taking this medicine, since many drugs are known to pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Too much Lorazepam usually shows up as central nervous system depression, which can range from drowsiness all the way to coma. In mild cases, the person may be drowsy, mentally confused and lethargic. In more serious cases, especially when other drugs or alcohol were taken as well, the symptoms may include ataxia, hypotonia, hypotension, hypnotic states (stages I to III) and coma.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Lorazepam below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Loraxen 2 mg/ml
What is Loraxen 2 mg/ml Injection?
Loraxen 2 mg/ml Injection is a medicine that contains Lorazepam. It is made by Techno Drugs Ltd., Satipara, Narshingdi. It belongs to the Benzodiazepine hypnotics group of medicines.
What is Loraxen used for?
Loraxen is used for: Nausea and Vomiting, Anxiety, Insomnia, Cancer.
What are the side effects of Loraxen?
Adverse effects with Lorapam tend to show up early in treatment and usually ease off as the body adjusts or once the dose is reduced. The most common issue is sedation, along with dizziness, weakness and unsteadiness on the feet.
Can I take Loraxen during pregnancy or while breastfeeding?
Safety of Lorazepam during pregnancy has not been established. Since treatment with this medicine is rarely urgent, it should almost always be avoided during this period. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Loraxen?
Too much Lorazepam usually shows up as central nervous system depression, which can range from drowsiness all the way to coma. In mild cases, the person may be drowsy, mentally confused and lethargic. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Loraxen?
Store Lorazepam below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Loraxen?
Some medicines can interact with Lorazepam, for example: Bilastine, Mirogabalin Besylate, Moxonidine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Loraxen?
Loraxen is a prescription (Rx) medicine. Take it as your doctor advises.