More from Lopamiro
Other strengths and forms by Popular Pharmaceuticals PLC
Indications & Uses
Neuroradiology: Lumbar myelography and thoraco-cervical myelography. Angiography: Used for cerebral angiography, selective coronary angiography, left ventriculography, aortography, angiocardiography, selective visceral arteriography, peripheral arteriography, digital subtraction angiography, venography, and urography. Other diagnostic procedures: Also used for contrast enhancement in CT scanning, as well as arthrography and fistulography.
Pharmacology
Iopamidol is an organic iodine compound used as a non-ionic, water-soluble contrast medium for X-ray imaging. It works by blocking X-rays as they pass through the body, which allows body structures that don't contain iodine to be seen more clearly. The more Iopamidol present in the path of the X-rays, the greater the opacity produced, and how well internal structures show up depends on how the drug is distributed through the body and later eliminated.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
Adults: In neurology, for lumbar myelography and thoraco-cervical myelography, Iopamidol 370 is given at 6 to 13 ml. For urography, Iopamidol 370 is given at 40 to 80 ml, or IV up to 1.5 ml/kg in severe renal disease.
Children: The usual dose is 1 to 2.5 ml/kg.
Other diagnostic procedures: For contrast enhancement in CT scanning, Iopamidol 370 is given at 0.5 to 2.0 ml/kg.
Angiography: For cerebral angiography, Iopamidol 370 is given at 6 to 13 ml. For selective coronary arteriography, 4 to 8 ml per artery. For peripheral arteriography, 20 to 50 ml. For venography, 24 to 60 ml. For angiocardiography, 30 to 80 ml. For left ventriculography, 30 to 80 ml. For percutaneous transfemoral or renal arteriography, 30 ml. For selective renal arteriography, 5 to 10 ml. For hepatic angiography, 70 ml. For coeliac angiography, 40 to 70 ml. For superior mesenteric angiography, 25 to 50 ml. For inferior mesenteric angiography, 5 to 30 ml. For digital subtraction angiography, 30 to 50 ml (10 to 20 ml per second) of Iopamidol 370 is given IV; for cardiac imaging, 25 ml is given for the left ventricle and 2 to 5 ml for the coronary arteries, at 15 ml per second, of Iopamidol 370 given intra-arterially.
Side Effects
Iopamidol belongs to the group of organic iodine compounds, and like others in this group it can cause unwanted side effects, including signs of anaphylaxis (a severe allergic reaction). The symptoms can include nausea, vomiting, widespread redness of the skin, a feeling of heat all over the body, headache, runny nose, fever, sweating, weakness, dizziness, paleness, shortness of breath, and moderate low blood pressure. Some people get skin reactions, which may appear as different types of rash or as widespread blisters. Some reactions affect the heart and blood circulation. These can include widening of the blood vessels with marked low blood pressure, a fast heartbeat, shortness of breath, agitation, a bluish colour of the skin or lips, and loss of consciousness. These more serious reactions may need emergency treatment. During heart or coronary artery imaging, an irregular heartbeat from the lower chambers of the heart (ventricular arrhythmia) may occasionally happen. People who have previously been treated for Graves' disease may find that their hyperthyroidism (an overactive thyroid) comes back.
Cautions & Contraindications
Warnings & Precautions
Amidol 370/300 should not be drawn into the syringe until immediately before it is used, and once the bottle has been opened it must be used at once. Because of the possibility of serious side effects, organoiodinate contrast media should be used only where there is a genuine need for a radiographic contrast examination, and this should be judged against the patient's clinical status, particularly with regard to any disease of the cardiovascular, urinary, or hepatobiliary system. Contrast media intended for cardioangiography in particular should be used only in hospitals or clinics equipped and staffed to handle intensive-care emergencies. For other diagnostic procedures that call for an iodinated contrast medium, the facility should have resuscitation equipment and emergency treatment on hand at all times. When examining small children or babies, fluid intake should not be restricted before a hypertonic contrast solution is given, and any existing water or electrolyte imbalance should be corrected beforehand. Where possible, X-ray examinations in women should also be carried out during the pre-ovulation phase of the menstrual cycle. For patients due to have a thyroid examination with a radioactive iodine tracer, it should be kept in mind that iodine uptake by the thyroid gland will be reduced for several days, and for up to two weeks, after a dose of an iodinated contrast medium that is cleared through the kidneys. Biguanide oral anti-diabetic agents, such as metformin, are excreted unchanged by the kidneys and so compete with contrast media for renal excretion, which can lead to a reduction in kidney function. Patients with NIDDM (non-insulin-dependent diabetes mellitus) who are taking metformin or another biguanide should therefore be told not to take the drug for 48 hours before and 48 hours after the X-ray examination.
Contraindications
There are no absolute contraindications for the use of Amidol, with the possible exception of Waldenström's macroglobulinemia, multiple myeloma, and severe liver or kidney disease.
Pregnancy & Breastfeeding
Pregnancy: Iopamidol injection should be given only if the physician considers the procedure essential. Studies have found no effect of Iopamidol on fertility or mutagenicity. Teratogenicity studies in rats and rabbits showed no effect at doses up to 8.2 g/kg (rat) and 4.1 g/kg (rabbit).
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone is given too much Iopamidol, treatment focuses on supporting all the vital functions of the body. Symptomatic therapy should also be started promptly.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Amidol away from light and store it below 30°C. In rare cases, crystals can form in Amidol injections. This has been traced to a damaged container, so don't use the product if you see it. Once a bottle has been opened, use it straight away. Throw away any contrast medium that is left over.
Drug Interactions
Common questions about Lopamiro 370 mg/ml
What is Lopamiro 370 mg/ml Injection?
Lopamiro 370 mg/ml Injection is a medicine that contains Iopamidol. It is made by Popular Pharmaceuticals PLC. It belongs to the Contrast medium for diagnostic procedures group of medicines.
What is Lopamiro used for?
Neuroradiology: Lumbar myelography and thoraco-cervical myelography. Angiography: Used for cerebral angiography, selective coronary angiography, left ventriculography, aortography, angiocardiography, selective visceral arteriography, peripheral arteriography, digital subtraction angiography, venography, and urography.
What are the side effects of Lopamiro?
Iopamidol belongs to the group of organic iodine compounds, and like others in this group it can cause unwanted side effects, including signs of anaphylaxis (a severe allergic reaction). The symptoms can include nausea, vomiting, widespread redness of the skin, a feeling of heat all over the body, headache, runny nose, fever, sweating, weakness, dizziness, paleness, shortness of breath, and moderate low blood pressure.
Can I take Lopamiro during pregnancy or while breastfeeding?
Pregnancy: Iopamidol injection should be given only if the physician considers the procedure essential. Studies have found no effect of Iopamidol on fertility or mutagenicity. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lopamiro?
If someone is given too much Iopamidol, treatment focuses on supporting all the vital functions of the body. Symptomatic therapy should also be started promptly. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lopamiro?
Keep Amidol away from light and store it below 30°C. In rare cases, crystals can form in Amidol injections.
Can I take other medicines with Lopamiro?
Some medicines can interact with Iopamidol, for example: Metformin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Lopamiro?
Lopamiro is a prescription (Rx) medicine. Take it as your doctor advises.