Indications & Uses
Vasculex injection is used to treat significant low blood pressure that occurs mainly due to blood vessel widening during anesthesia.
Pharmacology
Phenylephrine is an alpha-1 adrenergic receptor agonist. Following intravenous administration of phenylephrine, increases in systolic and diastolic blood pressures and arterial blood pressure are observed. The onset of blood pressure increase is rapid, typically within minutes. Following intravenous administration of phenylephrine hydrochloride, increases in systolic and diastolic blood pressures, mean arterial blood pressure, and total peripheral vascular resistance are observed. The onset of blood pressure increase following an intravenous bolus dose of phenylephrine hydrochloride is rapid, typically within minutes. As blood pressure increases following intravenous administration, vagal activity also increases, resulting in reflex bradycardia. Phenylephrine acts on most vascular beds, including the renal, pulmonary, and splanchnic arteries.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosing to raise blood pressure during anaesthesia: The usual starting dose is 40 to 100 mcg given as an intravenous bolus. Further boluses may be given every 1-2 minutes as needed, but no more than 200 mcg should be given in any single dose. Do not use the solution if it appears coloured, cloudy, or contains visible particles. Discard any portion that is not used.
Side Effects
Side effects of Vasculex mainly result from its pharmacologic activity being stronger than intended. Reports from published clinical studies, observational trials, and case reports have noted reactions such as reflex bradycardia, ischemia, high blood pressure, vomiting, nausea, neck pain, and tremors, affecting various body systems.
Cautions & Contraindications
Warnings & Precautions
Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension Because Vasculex raises blood pressure, it can bring on angina in patients with severe arteriosclerosis or a history of angina. It can also worsen existing heart failure and increase pulmonary arterial pressure. Bradycardia Vasculex can cause severe bradycardia and reduce cardiac output. Renal Toxicity Vasculex can increase the need for renal replacement therapy in patients with septic shock. Renal function should be monitored.
Pregnancy & Breastfeeding
Data from randomized controlled trials and meta-analyses of Phenylephrine injection used during caesarean section have not shown a drug-related risk of major birth defects or miscarriage. No data are available on its use during the first or second trimester. It is also not known whether Phenylephrine injection or its metabolite passes into human or animal breast milk, nor whether it affects the breastfed infant or milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Too much Phenylephrine Hydrochloride can make blood pressure rise quickly. The signs of overdose are headache, vomiting, hypertension, reflex bradycardia, a feeling of fullness in the head, tingling in the hands and feet, and cardiac arrhythmias.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Phenylephrine Hydrochloride below 30°C, in a dry place and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Locotrix IV/IM/SC Inj 10 mg/ml
What is Locotrix IV/IM/SC Inj 10 mg/ml Injection?
Locotrix IV/IM/SC Inj 10 mg/ml Injection is a medicine that contains Phenylephrine Hydrochloride. It is made by General Pharmaceuticals Ltd, Unit-2. It belongs to the Alpha adrenoceptor blocking drugs group of medicines.
What is Locotrix IV/IM/SC Inj used for?
Vasculex injection is used to treat significant low blood pressure that occurs mainly due to blood vessel widening during anesthesia.
What are the side effects of Locotrix IV/IM/SC Inj?
Side effects of Vasculex mainly result from its pharmacologic activity being stronger than intended. Reports from published clinical studies, observational trials, and case reports have noted reactions such as reflex bradycardia, ischemia, high blood pressure, vomiting, nausea, neck pain, and tremors, affecting various body systems.
Can I take Locotrix IV/IM/SC Inj during pregnancy or while breastfeeding?
Data from randomized controlled trials and meta-analyses of Phenylephrine injection used during caesarean section have not shown a drug-related risk of major birth defects or miscarriage. No data are available on its use during the first or second trimester. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Locotrix IV/IM/SC Inj?
Too much Phenylephrine Hydrochloride can make blood pressure rise quickly. The signs of overdose are headache, vomiting, hypertension, reflex bradycardia, a feeling of fullness in the head, tingling in the hands and feet, and cardiac arrhythmias. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Locotrix IV/IM/SC Inj?
Keep Phenylephrine Hydrochloride below 30°C, in a dry place and away from light. Keep it out of the reach of children.
Can I take other medicines with Locotrix IV/IM/SC Inj?
Some medicines can interact with Phenylephrine Hydrochloride, for example: Oxytocin, Atropine Sulphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Locotrix IV/IM/SC Inj?
Locotrix IV/IM/SC Inj is a prescription (Rx) medicine. Take it as your doctor advises.