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These brands contain the same active ingredient (Linezolid). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Lizox
Other strengths and forms by Aristopharma Limited
Indications & Uses
Lizox is indicated for:
Pharmacology
Linezolid is a synthetic antibacterial agent belonging to a newer class of antibiotics called the oxazolidinones. In laboratory testing it has shown activity against Gram-positive aerobic bacteria, some Gram-positive anaerobic bacteria, and certain Gram-negative bacteria. It works by selectively blocking bacterial protein synthesis, through a mechanism of action different from that of other antibacterial agents. Linezolid binds to the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, preventing the formation of a functional 70S initiation complex, an essential step in bacterial translation. Time-kill studies have shown Linezolid to be bacteriostatic against enterococci and staphylococci, while against streptococci it was found to be bactericidal for most strains.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Linezolid tablets can be taken by mouth, with or without food. Linezolid IV infusion should be given by intravenous infusion over 30 to 120 minutes. The recommended daily dosage for Linezolid tablets and IV infusion is as follows:
For nosocomial pneumonia: pediatric patients from birth through 11 years of age should receive 10 mg per kg orally or intravenously every 8 hours; adults and adolescents aged 12 years and older should receive 600 mg orally or intravenously every 12 hours; treatment should continue for 10 to 14 consecutive days.
For community acquired pneumonia (including cases with concurrent bacteremia) and for complicated skin and skin structure infections: pediatric patients from birth through 11 years of age should receive 10 mg per kg orally or intravenously every 8 hours; adults and adolescents aged 12 years and older should receive 600 mg orally or intravenously every 12 hours; treatment should continue for 14 to 28 consecutive days.
For uncomplicated skin and skin structure infections: children under 5 years should receive 10 mg per kg orally every 8 hours, and children aged 5 to 11 years should receive 10 mg per kg orally every 12 hours; adults should receive 400 mg orally every 12 hours, while adolescents should receive 600 mg orally every 12 hours; treatment should continue for 10 to 14 consecutive days.
Note on neonates under 7 days old: most pre-term neonates under 7 days of age (gestational age under 34 weeks) have lower systemic linezolid clearance and larger AUC values than many full term neonates and older infants. These neonates should start on 10 mg per kg every 12 hours. In neonates with a less than ideal clinical response, a regimen of 10 mg per kg every 8 hours may be considered. By 7 days of life, all neonatal patients should be receiving 10 mg per kg every 8 hours. No dose adjustment is needed when switching from intravenous to oral administration.
Regarding intravenous administration: the IV infusion should be checked visually against a light source for particulate matter before it is given. It may show a yellow color that can deepen over time without any loss of potency. Do not connect this IV infusion vial in series with other vials, and do not add any other substances to the solution. Any unused portion should be discarded after a single use.
Regarding hepatic impairment: no dose adjustment is needed for patients with mild to moderate hepatic impairment. Linezolid's pharmacokinetics have not been studied in patients with severe hepatic impairment.
Regarding use in children and adolescents: dosing for this age group is described above. Using linezolid as empiric treatment for pediatric patients with central nervous system infections is not recommended.
Side Effects
Most people who took Linwin experienced side effects that were mild to moderate rather than severe. Diarrhea, headache, and nausea were the ones seen most often. Less commonly, it may also cause oral or vaginal thrush (moniliasis), high blood pressure, indigestion, localized abdominal pain, itching, or a change in tongue color.
Cautions & Contraindications
Warnings & Precautions
Weekly complete blood counts are advised for patients on Linwin, especially those treated for more than two weeks, those with pre-existing myelosuppression, those taking other drugs that suppress the bone marrow, or those with a chronic infection who have had previous or concurrent antibiotic therapy. Patients who notice signs of visual trouble, such as blurred vision, changes in visual acuity or color vision, or a visual field defect, should have an eye examination promptly. Linwin is not approved for treating catheter-related bloodstream infections or catheter-site infections and should not be used for these. A careful medical history should be taken, since Clostridium difficile-associated Diarrhea (CDAD) has been reported more than two months after antibiotic use. If CDAD is suspected or confirmed, it may be necessary to stop any ongoing antibiotic that does not target C. difficile. Linwin should not be given to patients with uncontrolled hypertension, pheochromocytoma or thyrotoxicosis, or to those taking sympathomimetic, vasopressive or dopaminergic agents, unless blood pressure is being monitored. Patients who develop recurrent nausea or vomiting, unexplained acidosis or a low bicarbonate level while on Linwin should be evaluated by a doctor right away. If hypoglycemia occurs, the dose of insulin or an oral hypoglycemic agent may need to be reduced, or the oral hypoglycemic agent, insulin or Linwin may need to be stopped.
Contraindications
Linezolid must not be used in patients with known hypersensitivity to Linezolid or to any other component of the product. It should not be given to patients taking a medicinal product that inhibits monoamine oxidase A or B (such as Phenelzine or Isocarboxazid), or within two weeks of taking such a product. It should also not be given to patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis or carcinoid syndrome, or to patients taking directly or indirectly acting sympathomimetic agents (such as Pseudoephedrine), vasopressive agents (such as Epinephrine or Norepinephrine), dopaminergic agents (such as Dopamine or Dobutamine), serotonin re-uptake inhibitors, tricyclic antidepressants, serotonin 5-HT1 receptor agonists (triptans), meperidine or buspirone.
Pregnancy & Breastfeeding
Pregnancy: Available data on linezolid use in pregnant women have not shown a drug-associated risk of major birth defects, miscarriage, or adverse effects on the mother or fetus. Even so, linezolid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: Linezolid does pass into breast milk. When deciding whether a breastfeeding mother should take it, the developmental and health benefits of breastfeeding should be weighed against her clinical need for linezolid and any possible adverse effects on the nursing infant from the drug or from the mother's underlying condition. Breastfeeding mothers taking linezolid should be advised to watch their infant for diarrhea and vomiting.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No overdose cases have been reported with Ezolid. If one happens, the patient should get symptomatic and supportive care, and glomerular filtration should be maintained. About 30% of an Ezolid dose is removed during 3 hours of haemodialysis. There are no data on whether peritoneal dialysis or haemoperfusion removes Ezolid.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Linezolid at room temperature, between 15°C and 30°C, and away from light and moisture. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Lizox 400 mg
What is Lizox 400 mg Tablet?
Lizox 400 mg Tablet is a medicine that contains Linezolid. It is made by Aristopharma Limited. It belongs to the Macrolides group of medicines.
What is Lizox used for?
Lizox is used for: Pneumonia, Skin and Soft Tissue Infection.
What are the side effects of Lizox?
Most people who took Linwin experienced side effects that were mild to moderate rather than severe. Diarrhea, headache, and nausea were the ones seen most often.
Can I take Lizox during pregnancy or while breastfeeding?
Pregnancy: Available data on linezolid use in pregnant women have not shown a drug-associated risk of major birth defects, miscarriage, or adverse effects on the mother or fetus. Even so, linezolid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lizox?
No overdose cases have been reported with Ezolid. If one happens, the patient should get symptomatic and supportive care, and glomerular filtration should be maintained. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lizox?
Keep Linezolid at room temperature, between 15°C and 30°C, and away from light and moisture. As with all medicines, keep it out of the reach of children.
Can I take other medicines with Lizox?
Some medicines can interact with Linezolid, for example: Buspirone, Pethidine, Mirtazapine, Clindamycin + Benzoyl peroxide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Lizobest by One Pharma Ltd. has the same ingredient and strength for ৳50.00 per unit, compared with ৳60.00 for Lizox. Ask your doctor or pharmacist before switching.
Do I need a prescription for Lizox?
Lizox is a prescription (Rx) medicine. Take it as your doctor advises.