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Same active ingredient — pay up to 38% less
These brands contain the same active ingredient (Atorvastatin + Ezetimibe). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Liptor EZ
Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Liptor EZ is indicated for:
Pharmacology
Atorvastatin lowers plasma cholesterol and lipoprotein levels in animal models. It blocks HMG-CoA reductase, so the liver makes less cholesterol, and it increases the number of LDL receptors on the surface of liver cells, so more LDL is taken up and broken down. It also reduces LDL production and the number of LDL particles.
Ezetimibe lowers blood cholesterol by blocking its absorption in the small intestine. Its molecular target is the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), which takes up cholesterol and phytosterols in the intestine. In a 2-week clinical study in 18 patients with hypercholesterolemia, ezetimibe reduced intestinal cholesterol absorption by 54% compared with placebo. It had no clinically meaningful effect on plasma levels of the fat-soluble vitamins A, D and E, and it did not impair adrenocortical steroid hormone production. Ezetimibe does not block cholesterol synthesis in the liver, and it does not increase bile acid excretion. It sits at the brush border of the small intestine and stops cholesterol being absorbed, so less cholesterol from the intestine reaches the liver. The liver's cholesterol stores fall, and cholesterol is cleared from the blood faster. This mechanism is different from that of statins and complements it.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dosage range for Atorvastatin + Ezetimibe is 10/10 mg to 80/20 mg daily. Most people start on 10/10 mg or 20/10 mg daily. You can take it as a single dose at any time of the day, with or without food. If a patient needs a larger reduction in LDL-C (greater than 55%), the recommended starting dose is 40/10 mg daily. Lipid levels should be checked within 2 or more weeks after starting this medicine and after any change in dose, and the dose adjusted accordingly.
Patients with Homozygous Familial Hypercholesterolemia: The dose is 40/10 mg or 80/10 mg daily. In these patients, Atorvastatin + Ezetimibe should be used as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis), or when such treatments are unavailable.
Patients with Hepatic Impairment: This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels.
Patients with Renal Impairment: A history of renal impairment may be a risk factor for statin-associated myopathy, so these patients need closer monitoring for skeletal muscle effects. No dose adjustment is necessary in renal impairment.
Side Effects
Atorvastatin + Ezetimibe can cause rhabdomyolysis, myopathy, myalgia, abdominal pain, and liver enzyme abnormalities, including increased hepatic enzymes. These are the common side effects.
Cautions & Contraindications
Warnings & Precautions
Myopathy, including rhabdomyolysis, has been reported when atorvastatin is taken together with colchicine, so take care when prescribing Atorvastatin + Ezetimibe with colchicine. The medicine should be stopped for a while, or discontinued, in any patient who has an acute, serious condition suggestive of myopathy. The same applies to a patient with a risk factor that makes renal failure likely as a result of rhabdomyolysis. Liver Enzymes Liver enzyme tests are recommended before starting Atorvastatin + Ezetimibe, and they should be repeated as clinically indicated. If serious liver injury occurs during treatment, with clinical symptoms and/or hyperbilirubinemia or jaundice, interrupt the therapy promptly. If no other cause is found, don't restart Atorvastatin + Ezetimibe. Active liver disease or unexplained persistent transaminase elevations are contraindications to its use. Endocrine Function Take care if Atorvastatin + Ezetimibe is given together with drugs that may lower the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone and cimetidine.
Pregnancy & Breastfeeding
Atorvastatin + Ezetimibe is Pregnancy Category X. This tablet must not be used by women who are pregnant or who may become pregnant. Serum cholesterol and triglycerides rise during a normal pregnancy, and lipid-lowering drugs give no benefit at this time, because the fetus needs cholesterol and cholesterol derivatives to develop normally. Atherosclerosis is a chronic process, so stopping lipid-lowering drugs during pregnancy should have little effect on the long-term results of treatment for primary hypercholesterolemia.
For breastfeeding, it isn't known whether atorvastatin passes into human milk. A small amount of another drug in this class does pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: the safety and effectiveness of atorvastatin + ezetimibe have not been established in pediatric patients.
Older people: no dosage adjustment is necessary in geriatric patients.
Overdose
There's no specific treatment for an overdose of Atorvastatin + Ezetimibe. If someone takes too much, the doctor treats the symptoms as they appear and gives supportive care as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Atorvastatin + Ezetimibe below 30°C, in a dry place. Keep it away from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Liptor EZ 10 mg+10 mg
What is Liptor EZ 10 mg+10 mg Tablet?
Liptor EZ 10 mg+10 mg Tablet is a medicine that contains Atorvastatin + Ezetimibe. It is made by The ACME Laboratories Ltd. It belongs to the Other lipid regulating drugs group of medicines.
What is Liptor EZ used for?
Liptor EZ is used for: Hyperlipidemia.
What are the side effects of Liptor EZ?
Atorvastatin + Ezetimibe can cause rhabdomyolysis, myopathy, myalgia, abdominal pain, and liver enzyme abnormalities, including increased hepatic enzymes. These are the common side effects.
Can I take Liptor EZ during pregnancy or while breastfeeding?
Atorvastatin + Ezetimibe is Pregnancy Category X. This tablet must not be used by women who are pregnant or who may become pregnant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Liptor EZ?
There's no specific treatment for an overdose of Atorvastatin + Ezetimibe. If someone takes too much, the doctor treats the symptoms as they appear and gives supportive care as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Liptor EZ?
Store Atorvastatin + Ezetimibe below 30°C, in a dry place. Keep it away from light, and keep it out of the reach of children.
Can I take other medicines with Liptor EZ?
Some medicines can interact with Atorvastatin + Ezetimibe, for example: Gemfibrozil, Cyclosporine, Niacin, Clarithromycin, Digoxin, Itraconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
ATV Eze by Delta Pharma PLC. has the same ingredient and strength for ৳10.00 per unit, compared with ৳16.00 for Liptor EZ. Ask your doctor or pharmacist before switching.
Do I need a prescription for Liptor EZ?
Liptor EZ is a prescription (Rx) medicine. Take it as your doctor advises.