Pricing
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All price changes →Indications & Uses
Lasgrain is indicated for:
Pharmacology
In the past, acute migraine headaches were treated by constricting the blood vessels of the brain, because the sudden widening of these vessels seen during a migraine was thought to cause the pain. The neurogenic hypothesis of migraine pathophysiology is an alternative to this vascular hypothesis. It suggests that cerebral vasodilation is a secondary mechanism in migraine pathogenesis, and that the main contributor to the headache pain is increased pathogenic firing of the trigeminal nerve pathways. While the precise mechanism of action of lasmiditan is unclear, it likely supports this neurogenic hypothesis, with its therapeutic effects coming from potent and selective agonism of the 5-HT1F receptor. These receptors are found in both the central and peripheral nervous system (on the central and peripheral ends of trigeminal neurons), and they appear to contribute to hyperpolarization of nerve terminals and inhibition of trigeminal neuronal activity. So lasmiditan's agonism at these receptors may inhibit the firing of the trigeminal nerves responsible for migraine headache pain. Lasmiditan has virtually no affinity for other 5-HT receptor subtypes or monoamine receptors (e.g. adrenergic, dopaminergic).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Lasmiditan is 50 mg, 100 mg or 200 mg, taken by mouth when needed. Take no more than one dose in 24 hours. Don't take Lasmiditan unless you can wait at least 8 hours between the dose and driving or operating machinery. A second dose has not been shown to work for the same migraine attack. The safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established. You can take Lasmiditan with or without food.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Hepatic Impairment
No dosage adjustment is needed for patients with mild or moderate hepatic impairment (Child-Pugh A or B). In patients with severe hepatic impairment (Child-Pugh C), use of Lasmiditan is not recommended.
Side Effects
The most common side effects of Lasmiditan Hemisuccinate are dizziness, fatigue, paresthesia and sedation.
Cautions & Contraindications
Warnings & Precautions
Driving impairment Patients should not drive or operate machinery until at least 8 hours after each dose of Lasmiditan Hemisuccinate. A patient who can't follow this advice should not take Lasmiditan Hemisuccinate. People may not be able to judge for themselves how competent their driving is, or how much impairment the medicine has caused. Central Nervous System (CNS) depression Lasmiditan Hemisuccinate may cause CNS depression. Use it with caution if it is taken together with alcohol or other CNS depressants. Serotonin syndrome Reactions consistent with serotonin syndrome have been reported in patients treated with Lasmiditan Hemisuccinate. If symptoms of serotonin syndrome occur, stop the medicine. Medication overuse headache Detoxification may be necessary.
Pregnancy & Breastfeeding
Pregnancy: There are no adequate data on the developmental risk of using Lasmiditan in pregnant women. In animal studies, harmful effects on development were seen. These were more fetal abnormalities, more deaths of the embryo, fetus and offspring, and lower fetal body weight. They occurred at maternal exposures lower than those seen clinically in rabbits and higher than those seen clinically in rats.
Lactation: There are no data on whether Lasmiditan is present in human milk, what it does to a breastfed infant, or what it does to milk production. In lactating rats given Lasmiditan by mouth, Lasmiditan and/or its metabolites passed into the milk at levels about 3 times those in the mother's plasma.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Lasmiditan Hemisuccinate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Lasgrain 100 mg
What is Lasgrain 100 mg Tablet?
Lasgrain 100 mg Tablet is a medicine that contains Lasmiditan Hemisuccinate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other drugs for migraine group of medicines.
What is Lasgrain used for?
Lasgrain is used for: Migraine.
What are the side effects of Lasgrain?
The most common side effects of Lasmiditan Hemisuccinate are dizziness, fatigue, paresthesia and sedation.
Can I take Lasgrain during pregnancy or while breastfeeding?
Pregnancy: There are no adequate data on the developmental risk of using Lasmiditan in pregnant women. In animal studies, harmful effects on development were seen. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Lasgrain?
Store Lasmiditan Hemisuccinate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Lasgrain?
Some medicines can interact with Lasmiditan Hemisuccinate, for example: Propranolol Hydrochloride, Dextromethorphan Hydrobromide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Lasgrain is already among the lowest-priced brands of Lasmiditan Hemisuccinate at this strength.
Do I need a prescription for Lasgrain?
Lasgrain is a prescription (Rx) medicine. Take it as your doctor advises.