Pricing
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Same active ingredient — pay up to 1% less
These brands contain the same active ingredient (Dexketoprofen). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Keto-D is indicated for:
Pharmacology
Dexketoprofen is the S(+)-enantiomer of ketoprofen and accounts for ketoprofen's analgesic and anti-inflammatory effects. The inactive R(-)-enantiomer plays no part in these therapeutic effects but does add to the metabolic burden. Dexketoprofen is formulated as a trometamol salt, and its high water solubility allows it to be absorbed rapidly through the gut wall, giving it a faster onset of action than ketoprofen. Peak plasma concentrations are reached more quickly than with other widely used analgesics, with an onset of action of 30 minutes. Given as a tablet, dexketoprofen trometamol is absorbed rapidly, reaching maximum plasma concentration (tmax) within 0.25 to 0.75 hours, compared with a tmax of 0.5 to 3 hours for the S-enantiomer when the racemic drug is given as tablets or capsules made with the free acid. Peak plasma concentrations of 1.4 mg/L and 3.1 mg/L are reached after doses of dexketoprofen trometamol 12.5 mg and 25 mg, respectively. Between 70% and 80% of the administered dose is recovered in the urine within the first 12 hours, mostly as the acyl-glucuronoconjugated parent drug. No R(-)-ketoprofen appears in the urine after dexketoprofen (S(+)-ketoprofen) is given, confirming that the S(+)-enantiomer does not undergo bioinversion in humans. The anti-inflammatory potency of dexketoprofen has consistently matched that of twice the dose of ketoprofen.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dose of Dexketoprofen 25 mg tablets depends on the type, severity, and duration of the pain. The usual recommended dose is 1 tablet every 8 hours, with no more than 3 tablets in a day. Elderly patients and those with kidney or liver impairment should begin treatment with a total daily dose of no more than 2 tablets. The tablets are normally taken with food. For acute pain, it is recommended that the tablets be taken at least 30 minutes before a meal. Dexketoprofen is not recommended for children.
Side Effects
As with all medicines, Actidex 25 mg tablets may cause some unwanted effects in some patients. These are listed below and are typical of non-steroidal anti-inflammatory drugs. Common (1-10%): nausea, vomiting, diarrhoea, stomach pain or heartburn. Uncommon (0.1-1%): sleep disorders, nervousness, headache, dizziness, vertigo, palpitations, constipation, dry mouth, flatulence, skin rash, fatigue, hot flushes, shivering and general malaise. Rare (0.01-0.1%): stomach ulceration, gastric haemorrhage or perforation; pins and needles, high blood pressure, water retention, slowed breathing rate, raised hepatic enzymes and increased sweating. Very rare or isolated cases (below 0.01%): blurred vision, ringing in the ear, low blood pressure, haematological reactions, hepatic or renal damage, dermatological and photosensitivity reactions, bronchospasm or anaphylaxis. In patients with systemic lupus erythematosus or mixed connective tissue disease, anti-inflammatory medicines may rarely cause isolated cases of fever, headache and rigidity of the nape (back of the neck).
Cautions & Contraindications
Warnings & Precautions
Use Actidex tablets with caution in patients who are allergic to any other NSAIDs; in those with kidney disease, liver disease, heart disease or conditions causing fluid retention; and in those with a blood disorder, systemic lupus erythematosus or mixed connective tissue disease.
Contraindications
Dexketoprofen tablets should not be used by people who are allergic to this product, to aspirin, or to other non-steroidal anti-inflammatory medicines. They are also unsuitable for anyone who has had attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria or angioedema (swelling of the face, eyes, lips or tongue, or difficulty breathing) after taking aspirin or other non-steroidal anti-inflammatory medicines. The tablets should not be taken by people who have, or have previously had, a peptic ulcer or chronic gastro-intestinal disorders, or who have had gastro-intestinal haemorrhage (bleeding) in the past. They are not recommended for people who have suffered from bronchial asthma, or who have severe heart failure, moderate to severe kidney dysfunction, or severely impaired liver function. People with a bleeding disorder or a blood clotting disorder, and those taking an anticoagulant, should also avoid them. Finally, Dexketoprofen tablets should not be used during pregnancy or while breast-feeding.
Pregnancy & Breastfeeding
Dexketoprofen tablets are not advised for use during pregnancy or while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Dexketoprofen should not be given to children.
Storage
Store Dexketoprofen below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Keto-D 25 mg
What is Keto-D 25 mg Tablet?
Keto-D 25 mg Tablet is a medicine that contains Dexketoprofen. It is made by The ACME Laboratories Ltd. It belongs to the Drugs for Osteoarthritis group of medicines.
What is Keto-D used for?
Keto-D is used for: Pain, Inflammation.
What are the side effects of Keto-D?
As with all medicines, Actidex 25 mg tablets may cause some unwanted effects in some patients. These are listed below and are typical of non-steroidal anti-inflammatory drugs.
Can I take Keto-D during pregnancy or while breastfeeding?
Dexketoprofen tablets are not advised for use during pregnancy or while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Keto-D?
Store Dexketoprofen below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Keto-D?
Some medicines can interact with Dexketoprofen, for example: Cyclosporine, Zidovudine, Methotrexate, Pentoxifylline, Tacrolimus, Mifepristone. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Actidex by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳4.00 per unit, compared with ৳4.03 for Keto-D. Ask your doctor or pharmacist before switching.
Do I need a prescription for Keto-D?
Keto-D is a prescription (Rx) medicine. Take it as your doctor advises.