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Other brands with the same active ingredient
These brands contain the same active ingredient (Itraconazole). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Itratab 200 is indicated for:
Pharmacology
Itraconazole works by inhibiting Cytochrome P-450 dependent enzymes, which impairs the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells. Because ergosterol is important for the cell membrane to function properly, blocking its synthesis leads to a cascade of abnormalities in permeability, membrane bound enzyme activity, and coordination of chitin synthesis. This results in inhibition of growth, abnormal cell wall formation, and accumulation of intracellular lipids and membranous vesicles.
SUBA (Super Bio available) technology is a novel technology for enhancing the bioavailability of poorly soluble drugs. It uses a solid dispersion of drug in a polymer that improves the dissolution of poorly soluble drugs compared to their normal crystalline form. Itraconazole made with SUBA technology is an orally active triazole antifungal drug that has demonstrated a broad spectrum of activity and a favorable pharmacokinetic profile.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
100 mg and 200 mg preparations. For non-systemic fungal disease: vulvovaginal candidiasis, 200 mg twice daily for 01 day. Pityriasis versicolor, 200 mg once daily for 07 days. Tinea corporis and tinea cruris, 100 mg once daily for 15 days or 200 mg once daily for 7 days. Tinea pedis and tinea manuum, 100 mg once daily for 30 days. Oropharyngeal candidiasis, 100 mg once daily for 15 days; in AIDS or neutropenic patients the dose is increased to 200 mg once daily for 15 days because absorption is impaired in these groups. Onychomycosis (toenails with or without fingernail involvement), either 200 mg daily for 3 months, or a course (pulse) of 200 mg twice daily for 7 days, with subsequent courses repeated after a 21 day interval; fingernails need two courses and toenails three courses. For systemic fungal disease: aspergillosis, 200 mg once daily for 2 to 5 months, increased to 200 mg twice daily in invasive or disseminated disease. Candidiasis, 100 to 200 mg once daily for 3 weeks to 7 months, increased to 200 mg twice daily in invasive or disseminated disease. Non-meningeal cryptococcosis, 200 mg once daily for 10 weeks. Cryptococcal meningitis, 200 mg twice daily for 2 to 6 months. Histoplasmosis, 200 mg once daily to twice daily for 8 months. Maintenance in AIDS, 200 mg once daily until immune recovery. Prophylaxis in neutropenia, 200 mg once daily until immune recovery. The dose and duration of treatment for systemic fungal disease should be adjusted according to the clinical response.
65 mg and 130 mg preparations. For non-systemic fungal disease: vulvovaginal candidiasis, 130 mg twice daily for 1 day. Pityriasis versicolor, 65 mg twice daily for 7 days. Tinea corporis and tinea cruris, 65 mg daily for 15 days or 65 mg twice daily for 7 days. Tinea pedis and tinea manuum, 65 mg once daily for 30 days. Oropharyngeal candidiasis, 65 mg once daily for 15 days; in AIDS or neutropenic patients the dose is increased to 65 mg twice daily for 15 days because absorption is impaired in these groups. Onychomycosis (toenails with or without fingernail involvement), either 65 mg twice daily for 3 months, or a course (pulse) of 130 mg twice daily for 7 days, with subsequent courses repeated after a 21 day interval; fingernails need two courses and toenails three courses. For systemic fungal disease: aspergillosis, 65 mg twice daily for 2 to 5 months, increased to 130 mg twice daily in invasive or disseminated disease. Candidiasis, 65 to 130 mg once daily for 3 weeks to 7 months, increased to 65 mg twice daily in invasive or disseminated disease. Non-meningeal cryptococcosis, 65 mg twice daily for 10 weeks. Cryptococcal meningitis, 130 mg twice daily for 2 to 6 months. Histoplasmosis, 130 mg once daily to twice daily for 8 months. Maintenance in AIDS, 65 mg twice daily until immune recovery. Prophylaxis in neutropenia, 65 mg twice daily until immune recovery. The dose and duration of treatment for systemic antifungal disease should be adjusted according to the clinical response.
50 mg capsule. For non-systemic fungal disease (pityriasis versicolor, tinea corporis and tinea cruris, tinea pedis and tinea manuum, oropharyngeal candidiasis, and onychomycosis of the toenails with or without fingernail involvement), the dose and duration are as follows. Treatment doses: children older than 4 weeks and younger than 12 years, usual dose 1.25 to 2 mg/kg per dose (to a maximum initial dose of 100 mg) given twice daily, adjusted on the basis of therapeutic drug monitoring. For severe infections the dose may be increased to 5 mg/kg per dose (to a maximum initial dose of 100 mg) given twice daily, and the maximum daily dose may be raised further on the basis of therapeutic drug monitoring in discussion with the physicians. The dose should be rounded to the nearest 50 mg to make administration easier. Children 12 years and older, usual dose 50 mg to 100 mg once daily, which may be increased to 100 mg twice daily in severe infections. Prophylaxis doses: children 2 years and older, 2.5 mg/kg per dose given once daily (to a maximum initial dose of 200 mg daily), adjusted on the basis of therapeutic drug monitoring. For systemic fungal disease (aspergillosis, candidiasis, non-meningeal cryptococcosis, cryptococcal meningitis, and histoplasmosis), the dose and duration are as follows. Treatment doses: children older than 4 weeks and younger than 12 years, usual dose 1.25 to 2 mg/kg per dose (to a maximum initial dose of 100 mg) given twice daily, adjusted on the basis of therapeutic drug monitoring. For severe infections the dose may be increased to 5 mg/kg per dose (to a maximum initial dose of 100 mg) given twice daily, and the maximum daily dose may be raised further on the basis of therapeutic drug monitoring in discussion with the physicians. The dose should be rounded to the nearest 50 mg to make administration easier. Children 12 years and older, usual dose 50 mg to 100 mg once daily, which may be increased to 100 mg twice daily in severe infections. Prophylaxis doses: children 2 years and older, 2.5 mg/kg per dose given once daily (to a maximum initial dose of 200 mg daily), adjusted on the basis of therapeutic drug monitoring.
Side Effects
Nausea, abdominal pain, indigestion (dyspepsia), constipation, headache and dizziness have been reported with itraconazole. Some people also see raised liver enzymes, menstrual problems or allergic reactions. These can include itching, rash, hives and angioedema. Hepatitis and cholestatic jaundice have been reported, as have peripheral neuropathy and Stevens-Johnson syndrome. With longer use, low potassium (hypokalaemia), swelling (oedema) and hair loss have also been seen.
Cautions & Contraindications
Warnings & Precautions
Itraconazole is not absorbed properly when stomach acid is reduced. If you are taking medicines that neutralise stomach acid (for example, aluminium hydroxide), take them at least 2 hours after your dose of Canditra SB. Take this medicine straight after a full meal. In rare cases, hepatitis and jaundice have been reported, mostly in people treated for longer than one month. For this reason, liver function should be monitored in anyone on continuous treatment lasting more than one month.
Contraindications
Itraconazole should not be used by anyone with a known allergy to the drug or to any ingredient in the formulation. It is also not recommended for patients with severe liver disease. It should not be taken together with rifampin, which appears to first inhibit and then increase the breakdown of Itraconazole.
Pregnancy & Breastfeeding
Itraconazole should not be used during pregnancy, as it is contraindicated in this condition. Mothers taking Itraconazole are also advised against breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Itraconazole below 25°C, in a cool and dry place, and away from light. Keep all medicines out of the reach of children.
Drug Interactions
Common questions about Itratab 200 200 mg
What is Itratab 200 200 mg Tablet?
Itratab 200 200 mg Tablet is a medicine that contains Itraconazole. It is made by Albion Laboratories Ltd. It belongs to the Drugs for subcutaneous and mycoses group of medicines.
What is Itratab 200 used for?
Itratab 200 is used for: Fungal Infection, Vaginal Candidiasis.
What are the side effects of Itratab 200?
Nausea, abdominal pain, indigestion (dyspepsia), constipation, headache and dizziness have been reported with itraconazole. Some people also see raised liver enzymes, menstrual problems or allergic reactions.
Can I take Itratab 200 during pregnancy or while breastfeeding?
Itraconazole should not be used during pregnancy, as it is contraindicated in this condition. Mothers taking Itraconazole are also advised against breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Itratab 200?
Keep Itraconazole below 25°C, in a cool and dry place, and away from light. Keep all medicines out of the reach of children.
Can I take other medicines with Itratab 200?
Some medicines can interact with Itraconazole, for example: Lercanidipine Hydrochloride, Midazolam, Terfenadine, Simvastatin, Crizotinib, Osimertinib. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Itratab 200?
Itratab 200 is a prescription (Rx) medicine. Take it as your doctor advises.