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Indications & Uses
Indapril is indicated for:
Pharmacology
Perindopril is a nonsulphydryl ACE inhibitor used to treat hypertension. After it is taken by mouth, it is quickly hydrolysed to perindoprilat, its main active metabolite. ACE converts angiotensin I into angiotensin II, which narrows the blood vessels (a vasoconstrictor). Angiotensin II also stimulates the adrenal cortex to secrete aldosterone. When ACE activity is inhibited, angiotensin II levels fall, so there is less vasoconstriction and less aldosterone secretion. The drop in aldosterone may cause a small rise in serum potassium. Lower angiotensin II also means the body loses its negative feedback on renal renin secretion, and this raises plasma renin activity. Perindopril may also interfere with the breakdown of bradykinin, a vasodepressor peptide. It is not known whether this effect adds to the therapeutic action of perindopril. The way perindopril lowers BP appears to come mainly from suppression of the RAAS.
Indapamide is a sulphonamide derivative with an indole ring, and it is pharmacologically related to the thiazide group of diuretics. It inhibits the reabsorption of sodium in the cortical diluting segment. This increases the urinary excretion of sodium and chlorides and, to a lesser extent, of potassium and magnesium. Urine output goes up, and indapamide has an antihypertensive action as a result.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults take 1 to 2 tablets of Perindopril + Indapamide a day, preferably in the morning before a meal. If the patient has renal insufficiency, treatment should begin with an adequate dose.
Side Effects
Perindopril + Indapamide can cause nausea, vomiting, indigestion, diarrhoea and constipation. Some people get a headache, dizziness, trouble sleeping, weakness or a dry mouth. Low blood pressure (hypotension) is possible too. Other side effects are a persistent dry cough, angioedema and rash.
Cautions & Contraindications
Warnings & Precautions
Doctors should use Perindopril + Indapamide with caution in people with renal impairment, renal artery stenosis, heart failure, gout, diabetes or liver cirrhosis. The same care applies in elderly patients, and in those with atherosclerosis or with idiopathic or hereditary angioedema.
Contraindications
Perindopril + Indapamide must not be used in people who are hypersensitive to perindopril or indapamide, or to any other angiotensin-converting enzyme (ACE) inhibitor.
Pregnancy & Breastfeeding
No adequate and well-controlled studies have been done on pregnant women, so Perindopril + Indapamide is not recommended in pregnancy. Mothers taking Indapa- plus should not breastfeed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Perindopril + Indapamide can cause low blood pressure, nausea, vomiting, cramps, dizziness, sleepiness and mental confusion. Urine output may fall (oliguria) and can go on to stop altogether (anuria). Salt and water disturbances may also occur, such as low sodium and low potassium levels. To remove the medicine that has been swallowed, the stomach may be washed out (gastric lavage) or activated charcoal may be given. Fluid and electrolyte balance should be monitored and maintained.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Perindopril + Indapamide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Indapril 2 mg+0.625 mg
What is Indapril 2 mg+0.625 mg Tablet?
Indapril 2 mg+0.625 mg Tablet is a medicine that contains Perindopril + Indapamide. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Indapril used for?
Indapril is used for: Hypertension.
What are the side effects of Indapril?
Perindopril + Indapamide can cause nausea, vomiting, indigestion, diarrhoea and constipation. Some people get a headache, dizziness, trouble sleeping, weakness or a dry mouth.
Can I take Indapril during pregnancy or while breastfeeding?
No adequate and well-controlled studies have been done on pregnant women, so Perindopril + Indapamide is not recommended in pregnancy. Mothers taking Indapa- plus should not breastfeed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Indapril?
An overdose of Perindopril + Indapamide can cause low blood pressure, nausea, vomiting, cramps, dizziness, sleepiness and mental confusion. Urine output may fall (oliguria) and can go on to stop altogether (anuria). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Indapril?
Store Perindopril + Indapamide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Indapril is already among the lowest-priced brands of Perindopril + Indapamide at this strength.
Do I need a prescription for Indapril?
Indapril is a prescription (Rx) medicine. Take it as your doctor advises.