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Other brands with the same active ingredient
These brands contain the same active ingredient (Imeglimin Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Image 500 is indicated for:
Pharmacology
Imeglimin Hydrochloride works in two ways. (a) It amplifies glucose-stimulated insulin secretion (GSIS) and preserves β-cell mass. (b) It enhances insulin action, which includes the potential to inhibit hepatic glucose output and to improve insulin signalling in both liver and skeletal muscle. At the cellular and molecular level, Imeglimin may act by correcting mitochondrial dysfunction, a common underlying element of T2D pathogenesis. It has been observed to rebalance respiratory chain activity, with partial inhibition of Complex I and correction of deficient Complex III activity. This reduces reactive oxygen species formation (so oxidative stress falls) and prevents opening of the mitochondrial permeability transition pore, which is implicated in preventing cell death. In islets taken from diseased rodents with T2D, Imeglimin also enhances glucose-stimulated ATP generation and induces the synthesis of nicotinamide adenine dinucleotide (NAD+) through the 'salvage pathway'. NAD+ is a key mitochondrial co-factor, and its metabolites may also contribute to the increase in GSIS (via enhanced Ca++ mobilization). Imeglimin has also been shown to preserve β-cell mass in rodents with T2D. So it appears to target a key root cause of T2D, which is defective cellular energy metabolism. This potential mode of action is unique and has been shown to differ from that of other major therapeutic classes, including biguanides, sulphonylureas and glucagon-like peptide-1 receptor agonists.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults usually take 2 tablets (1,000 mg) at a time, twice a day, once in the morning and once in the evening. Please follow these instructions strictly.
If you miss a dose, take it as soon as you can. But if it's almost time for your next dose, skip the missed one and carry on with your regular schedule. Never take two doses at one time.
If you accidentally take more than the prescribed dose, consult your doctor immediately.
Side Effects
Nausea, diarrhea and constipation are the side effects people report most often with Imeglimin Hydrochloride. Some people may also feel weak or hungry and start sweating, which are signs of hypoglycaemia.
Cautions & Contraindications
Warnings & Precautions
Imeglimin Hydrochloride may cause hypoglycemic symptoms, so be careful if you work at heights, drive a car or operate dangerous machinery. If hypoglycemic symptoms do occur, take sugar-containing foods or sugar. If you are also taking an alfa-glucosidase inhibitor (acarbose, voglibose, miglitol) with this medicine, take glucose instead. For patients with renal impairment, eGFR<15 ml/min/1.73 m2, the dosage might need to be reduced.
Contraindications
Imeglimin tablets must not be used in patients who have hypersensitivity to the drug or any of its components. They are also contraindicated in severe ketosis, and in diabetic coma or pre-coma. The same applies when the aim is an immediate remedy for hyperglycemia in type 1 diabetes, where infusion and insulin are used.
Pregnancy & Breastfeeding
Pregnancy: The safety of Imeglimin in pregnant women hasn't been established. If a woman is pregnant or may possibly be pregnant, it should be used only when the expected benefits of treatment outweigh the possible risks.
Lactation: Breast-feeding must be stopped while a nursing mother is taking Imeglimin Hydrochloride, because transfer into milk has been reported in animal studies.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much Imeglimin Hydrochloride, the usual supportive measures are reasonable. These include removing any unabsorbed medicine from the gastrointestinal tract and monitoring the patient clinically, which includes taking an electrocardiogram. Supportive therapy should then be given if it is needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Imeglimin Hydrochloride below 30°C, in a dry place and away from light. As with all medicines, keep it out of reach of children.
Common questions about Image 500 500 mg
What is Image 500 500 mg Tablet?
Image 500 500 mg Tablet is a medicine that contains Imeglimin Hydrochloride. It is made by Everest Pharmaceuticals Ltd.
What is Image 500 used for?
Image 500 is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Image 500?
Nausea, diarrhea and constipation are the side effects people report most often with Imeglimin Hydrochloride. Some people may also feel weak or hungry and start sweating, which are signs of hypoglycaemia.
Can I take Image 500 during pregnancy or while breastfeeding?
Pregnancy: The safety of Imeglimin in pregnant women hasn't been established. If a woman is pregnant or may possibly be pregnant, it should be used only when the expected benefits of treatment outweigh the possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Image 500?
If someone takes too much Imeglimin Hydrochloride, the usual supportive measures are reasonable. These include removing any unabsorbed medicine from the gastrointestinal tract and monitoring the patient clinically, which includes taking an electrocardiogram. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Image 500?
Keep Imeglimin Hydrochloride below 30°C, in a dry place and away from light. As with all medicines, keep it out of reach of children.
Do I need a prescription for Image 500?
Image 500 is a prescription (Rx) medicine. Take it as your doctor advises.