More from Idatix
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Idatix is indicated for:
Pharmacology
Indapamide is an oral antihypertensive agent. Exactly how it lowers blood pressure has not been fully worked out, but both vascular and renal actions have been implicated. The possible benefits of Indapamide in hypertension include a reduction in cardiac hypertrophy and in the thickening of arterial walls, and prevention of the build-up of the embryonic isoform of fibronectin in coronary vessels. They also include free radical scavenging, which leads to stimulation of vasodilator eicosanoid formation, and an interaction with renal carbonic anhydrase.
In the kidney, Indapamide acts on the proximal segment of the distal tubule. It appears to have natriuretic properties, with sodium and chloride excreted in equivalent amounts, and it has less effect on kaliuresis or uric acid excretion. A noticeable increase in urinary volume is seen in man only at doses above 1.5 mg of Indapamide sustained release tablet a day. Clinical studies have not shown significant changes in plasma sodium levels. Significant hypokalemia (plasma potassium <3.2 mmol/L) has been reported in 4% of patients.
Absorption: The released fraction of Indapamide is absorbed rapidly and completely from the gastrointestinal tract. Taking it with food slightly increases the rate and extent of absorption, but these changes are unlikely to matter clinically. After a single dose, the peak serum level occurs about 12 hours after ingestion. Repeated dosing reduces the variation in serum levels between 2 doses.
Distribution: Indapamide spreads widely through the body and binds extensively to some specific sites. In blood it is highly bound to red blood cells (80%), and more specifically to carbonic anhydrase (98%), without significantly inhibiting this enzyme. Binding to plasma proteins is 79%. The plasma elimination half-life is 14 to 24 hours (mean 18 hours), and the volume of distribution is approximately 60L. Steady state is reached after 7 days, and repeated dosing does not lead to accumulation.
Metabolism: The liver metabolizes Indapamide extensively. Only 5 to 7% of the dose is excreted in the urine as unchanged drug.
Elimination: Elimination is mainly through the urine (70% of the dose) and the faeces (22%), in the form of inactive metabolites.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take one tablet daily, preferably in the morning. In more severe cases, Indapamide can be combined with other categories of anti-hypertensive agents. The safety and effectiveness in pediatric patients have not been established.
Use in Pediatric Patients: The safety and effectiveness in pediatric patients have not been established.
Side Effects
Indapamide may cause dizziness, headache, loss of appetite (anorexia), nausea, vomiting, constipation, diarrhoea and postural hypotension (a drop in blood pressure on standing). Electrolyte disturbances may also occur, including hypochloraemic alkalosis, hyponatraemia (low sodium), hypokalaemia (low potassium) and hyperuricaemia (raised uric acid). Hypersensitivity reactions have been reported, including skin rashes, cholestatic jaundice and blood disorders (blood dyscrasias) such as thrombocytopenia, leucopenia and aplastic anaemia.
Cautions & Contraindications
Warnings & Precautions
Indapamide should be used with caution in people who have a disturbed water or electrolyte balance, diabetes, gout, or kidney problems. Monitoring of serum potassium and uric acid levels is also recommended.
Contraindications
Indapamide should not be used by anyone with a known allergy to indapamide or to sulphonamides, or by those with renal failure, serious liver disease, or hypokalemia (low blood potassium).
Pregnancy & Breastfeeding
There are no adequate, well-controlled studies of Indapamide use in pregnant women, so it is not recommended during pregnancy. Mothers taking Indapamide should not breastfeed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Indapamide in a cool, dry place. Protect it from light and moisture.
Drug Interactions
Common questions about Idatix 1.5 mg
What is Idatix 1.5 mg Tablet?
Idatix 1.5 mg Tablet is a medicine that contains Indapamide. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Thiazide diuretics & related drugs group of medicines.
What is Idatix used for?
Idatix is used for: Hypertension, Heart Failure, Edema.
What are the side effects of Idatix?
Indapamide may cause dizziness, headache, loss of appetite (anorexia), nausea, vomiting, constipation, diarrhoea and postural hypotension (a drop in blood pressure on standing). Electrolyte disturbances may also occur, including hypochloraemic alkalosis, hyponatraemia (low sodium), hypokalaemia (low potassium) and hyperuricaemia (raised uric acid).
Can I take Idatix during pregnancy or while breastfeeding?
There are no adequate, well-controlled studies of Indapamide use in pregnant women, so it is not recommended during pregnancy. Mothers taking Indapamide should not breastfeed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Idatix?
Keep Indapamide in a cool, dry place. Protect it from light and moisture.
Can I take other medicines with Idatix?
Some medicines can interact with Indapamide, for example: Noradrenaline. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Idatix?
Idatix is a prescription (Rx) medicine. Take it as your doctor advises.