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Same active ingredient — pay up to 40% less
These brands contain the same active ingredient (Nitroglycerin). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
GTN SR is indicated for:
Pharmacology
The main way nitroglycerin works is by relaxing the smooth muscle in blood vessels. It widens both arteries and veins, though the effect is stronger on the veins. When the small veins after the capillaries widen, more blood collects in the limbs and other parts of the body, so less blood returns to the heart. This lowers the left ventricular end-diastolic pressure, which is known as preload. Relaxation of the arterioles lowers systemic vascular resistance and arterial pressure, which is the afterload.
Nitroglycerin releases free radical nitric oxide (NO). This activates guanylate cyclase, which raises the level of cyclic GMP (guanosine 3',5'-monophosphate) in smooth muscle and other tissues. Over time this causes dephosphorylation of myosin light chains. These chains control how tightly smooth muscle contracts, so the result is vasodilation.
Absorption: Nitroglycerin is absorbed quickly, which is why it is so often used in emergencies.
Distribution: The volume of distribution of nitroglycerin is 3 L/kg.
Metabolism: The liver breaks nitroglycerin down quickly, using its enzymes, into di-nitrates and mononitrates.
Elimination: The kidneys remove nitroglycerin from the body, mainly as its 2 di-nitro metabolites.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dose should always be adjusted according to the individual patient's requirement, response and the severity of the anginal pain. 2.6 mg: 1 tablet 2 times a day before meals, in the morning and at noon. If necessary, the dose may be raised gradually to 2 or 3 tablets twice daily. 6.4 mg: One tablet twice daily, or as directed by the registered physician.
Dosage for other forms (2)
One tablet (0.5 mg) should be dissolved under the tongue as soon as an acute anginal attack begins. The dose may be repeated about every five minutes until relief is obtained. If pain continues after a total of 3 tablets taken within 15 minutes, prompt medical attention is recommended.
At the onset of an attack, one metered dose spray or two metered dose sprays should be given under the tongue. A spray may be repeated about every 5 minutes as needed, up to a maximum of 3 metered sprays within a 15 minute period. If chest pain continues after a total of 3 sprays, prompt medical attention is recommended. It may also be used beforehand, 5 to 10 minutes ahead of activities that might bring on an acute attack.
Side Effects
The most common side effects are headache, flushing, and low blood pressure.
Cautions & Contraindications
Warnings & Precautions
Nitrofix SR works best at the lowest dose that relieves the acute anginal attack; using more than needed raises the risk of tolerance developing. It should be used cautiously in patients who are, or may already be, volume-depleted or hypotensive.
Contraindications
Contraindicated in patients using PDE5 inhibitors (sildenafil, vardenafil, or tadalafil), as well as those with severe anemia, raised intracranial pressure, hypersensitivity to nitroglycerin or other nitrates/nitrites, or acute circulatory failure (shock).
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding: The safety of nitrates during pregnancy and breastfeeding has not been established, as there is no clear evidence to confirm it. For this reason, doctors should only prescribe nitrates to pregnant women or nursing mothers when they judge it truly necessary. It is also not known whether Nitroglycerin passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Nitroglycerin has not been shown to be safe or effective in children, so its use in this age group is not established.
Overdose
If someone takes too much Nitroglycerin, by accident or on purpose, the toxic effects can include vomiting, restlessness, low blood pressure (hypotension), cyanosis, methemoglobinemia, a fast heartbeat (tachycardia) and fainting (syncope).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Nitroglycerin out of reach of children. Store it in a dry place below 25°C, and protect it from light.
Drug Interactions
Common questions about GTN SR 2.6 mg
What is GTN SR 2.6 mg Tablet (Sustained Release)?
GTN SR 2.6 mg Tablet (Sustained Release) is a medicine that contains Nitroglycerin. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Nitrates: Coronary vasodilators group of medicines.
What is GTN SR used for?
GTN SR is used for: Angina Pectoris.
What are the side effects of GTN SR?
The most common side effects are headache, flushing, and low blood pressure.
Can I take GTN SR during pregnancy or while breastfeeding?
Pregnancy & Breastfeeding: The safety of nitrates during pregnancy and breastfeeding has not been established, as there is no clear evidence to confirm it. For this reason, doctors should only prescribe nitrates to pregnant women or nursing mothers when they judge it truly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much GTN SR?
If someone takes too much Nitroglycerin, by accident or on purpose, the toxic effects can include vomiting, restlessness, low blood pressure (hypotension), cyanosis, methemoglobinemia, a fast heartbeat (tachycardia) and fainting (syncope). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store GTN SR?
Keep Nitroglycerin out of reach of children. Store it in a dry place below 25°C, and protect it from light.
Can I take other medicines with GTN SR?
Some medicines can interact with Nitroglycerin, for example: Amlodipine Besilate + Telmisartan, Tadalafil, Dobutamine Hydrochloride, Aspirin, Amlodipine Besilate + Benazepril Hydrochloride, Collagen Type-I + Chondroitin Sulfate + Sodium Hyaluronate + L-Arginine + Vitamin C. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Xynocard SR by The White Horse Pharmaceuticals Ltd. has the same ingredient and strength for ৳3.00 per unit, compared with ৳5.00 for GTN SR. Ask your doctor or pharmacist before switching.
Do I need a prescription for GTN SR?
GTN SR is a prescription (Rx) medicine. Take it as your doctor advises.