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Other brands with the same active ingredient
These brands contain the same active ingredient (Saxagliptin). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Glyza 2.5 is indicated for:
Pharmacology
Saxagliptin is an orally active inhibitor of the DPP4 enzyme. It works by competitively blocking DPP4, which slows the breakdown of incretin hormones. This raises their levels in the bloodstream and, in a glucose-dependent manner, lowers both fasting and after-meal (postprandial) glucose concentrations in people with type 2 diabetes mellitus.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose is 2.5 mg or 5 mg once daily, taken without regard to meals.
Patients with Renal Impairment: No dosage adjustment is recommended for patients with mild renal impairment (creatinine clearance >50 mL/min). For patients with moderate or severe renal impairment, or with end-stage renal disease (ESRD) requiring hemodialysis (creatinine clearance <50 mL/min), the dose is 2.5 mg once daily. Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis.
Because the dose of Saxagliptin should be limited to 2.5 mg based on renal function, assessment of renal function is recommended before starting Saxagliptin and periodically thereafter. Renal function can be estimated from serum creatinine using the Cockcroft-Gault formula or the Modification of Diet in Renal Disease formula.
Side Effects
Adverse reactions occurred in more than 5% of patients taking Glyza, and more often than with placebo, included upper respiratory tract infection, urinary tract infection, and headache. Swelling of the hands, ankles, or feet (peripheral edema) was more common when Glyza was combined with a thiazolidinedione (TZD) than with placebo plus a TZD. Low blood sugar (hypoglycemia) occurred more often when Glyza was combined with a sulfonylurea than with placebo plus a sulfonylurea. Allergic-type reactions, such as hives or swelling of the face, were also reported more frequently with Glyza than with placebo.
Cautions & Contraindications
Warnings & Precautions
Dosage adjustment of Glyza isn't needed when it's taken alongside rifampin, diltiazem, amprenavir, aprepitant, erythromycin, fluconazole, fosamprenavir, grapefruit juice, or verapamil. However, if it's given together with ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, or telithromycin, the Glyza dose should be limited to 2.5 mg.
Contraindications
Saxagliptin should not be used by anyone who has previously had an allergic reaction to it.
Pregnancy & Breastfeeding
Pregnancy Category B. Well-controlled studies in pregnant women are lacking, so, as with other antidiabetic medicines, Saxagliptin should be used in pregnancy only when clearly necessary. Whether Saxagliptin passes into human breast milk is not known; since many medicines do pass into breast milk, it should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
In a controlled clinical trial, healthy people took Saxagliptin by mouth once daily at doses up to 400 mg daily for 2 weeks (80 times the MRHD). There were no dose-related clinical adverse reactions, and no clinically meaningful effect on QTc interval or heart rate. If an overdose happens, start appropriate supportive treatment based on the patient's clinical status. Saxagliptin and its active metabolite are removed by hemodialysis (23% of the dose over 4 hours).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Saxagliptin at 20-25°C. Protect it from light and moisture, and keep it out of the reach of children.
Drug Interactions
Common questions about Glyza 2.5 2.5 mg
What is Glyza 2.5 2.5 mg Tablet?
Glyza 2.5 2.5 mg Tablet is a medicine that contains Saxagliptin. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Dipeptidyl Peptidase-4 (DPP-4) inhibitor group of medicines.
What is Glyza 2.5 used for?
Glyza 2.5 is used for: Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Glyza 2.5?
Adverse reactions occurred in more than 5% of patients taking Glyza, and more often than with placebo, included upper respiratory tract infection, urinary tract infection, and headache. Swelling of the hands, ankles, or feet (peripheral edema) was more common when Glyza was combined with a thiazolidinedione (TZD) than with placebo plus a TZD.
Can I take Glyza 2.5 during pregnancy or while breastfeeding?
Pregnancy Category B. Well-controlled studies in pregnant women are lacking, so, as with other antidiabetic medicines, Saxagliptin should be used in pregnancy only when clearly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Glyza 2.5?
In a controlled clinical trial, healthy people took Saxagliptin by mouth once daily at doses up to 400 mg daily for 2 weeks (80 times the MRHD). There were no dose-related clinical adverse reactions, and no clinically meaningful effect on QTc interval or heart rate. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Glyza 2.5?
Keep Saxagliptin at 20-25°C. Protect it from light and moisture, and keep it out of the reach of children.
Can I take other medicines with Glyza 2.5?
Some medicines can interact with Saxagliptin, for example: Carbamazepine, Atazanavir, Ritonavir, Ketoconazole, Phenobarbital. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Glyza 2.5?
Glyza 2.5 is a prescription (Rx) medicine. Take it as your doctor advises.