Pricing
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Indications & Uses
Giran is indicated for:
Pharmacology
Candesartan Cilexetil is an ester prodrug that is hydrolysed to its active form, Candesartan, during absorption from the gastrointestinal tract. Candesartan is an angiotensin II receptor (type AT1) antagonist. It blocks the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Hypertension: Start with 8 mg once daily. In hepatic impairment, start with 2 mg; in renal impairment or intravascular volume depletion, start with 4 mg. If necessary, the dose may be increased at intervals of 4 weeks, up to a maximum of 32 mg once daily. The usual maintenance dose is 8 mg once daily.
Heart failure: Start with 4 mg once daily. The dose may be increased at intervals of at least 2 weeks, up to the target dose of 32 mg once daily or the maximum tolerated dose.
Side Effects
Side effects are usually mild. Symptomatic low blood pressure (hypotension), including dizziness, may occur, particularly in patients whose fluid volume is depleted (for example, those taking high-dose diuretics). High blood potassium (hyperkalaemia) occurs occasionally, and angioedema has been reported with some angiotensin II receptor antagonists. Other reported effects include vertigo and headache, and, rarely, hepatitis, blood disorders, low blood sodium (hyponatraemia), back pain, joint pain (arthralgia), muscle pain (myalgia), rash, hives (urticaria) and itching (pruritus).
Cautions & Contraindications
Warnings & Precautions
Giran should be used with caution in patients with renal artery stenosis, aortic or mitral valve stenosis, or obstructive hypertrophic cardiomyopathy. Plasma potassium levels should be monitored, particularly in elderly patients and in those with renal impairment; a lower starting dose may be appropriate for these patients.
Contraindications
Do not use if you are allergic to any ingredient in this product. Also not for use during pregnancy, while breastfeeding, or in cholestasis.
Pregnancy & Breastfeeding
Discontinue Candesartan Cilexetil as soon as pregnancy is confirmed. The medicine may be used while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in children: the safety and effectiveness of Candesartan Cilexetil in pediatric patients have not been established.
Storage
Keep Candesartan Cilexetil in a cool, dry place. Protect it from light and moisture.
Drug Interactions
Common questions about Giran 16 mg
What is Giran 16 mg Tablet?
Giran 16 mg Tablet is a medicine that contains Candesartan Cilexetil. It is made by Aristopharma Limited. It belongs to the Angiotensin-ll receptor blocker group of medicines.
What is Giran used for?
Giran is used for: Hypertension, Heart Failure.
What are the side effects of Giran?
Side effects are usually mild. Symptomatic low blood pressure (hypotension), including dizziness, may occur, particularly in patients whose fluid volume is depleted (for example, those taking high-dose diuretics).
Can I take Giran during pregnancy or while breastfeeding?
Discontinue Candesartan Cilexetil as soon as pregnancy is confirmed. The medicine may be used while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Giran?
Keep Candesartan Cilexetil in a cool, dry place. Protect it from light and moisture.
Can I take other medicines with Giran?
Some medicines can interact with Candesartan Cilexetil, for example: Nifedipine, Hydrochlorothiazide, Digoxin, Candesartan Cilexetil + Hydrochlorothiazide, Glibenclamide, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Giran is already among the lowest-priced brands of Candesartan Cilexetil at this strength.
Do I need a prescription for Giran?
Giran is a prescription (Rx) medicine. Take it as your doctor advises.