Gadosol

Gadoterate is a paramagnetic molecule, which means it develops a magnetic moment when it sits in a magnetic field. That magnetic moment speeds up the relaxation rates of water protons close to it, so the signal intensity (the brightness) of the tissues goes up. In a magnetic field, gadoterate also shortens the T1 and T2 relaxation times in the target tissues.

Gadoteric Acid is Pregnancy Category C. No adequate and well-controlled studies have been done in pregnant women. There is limited published human data on other GBCAs given during pregnancy, and it showed no adverse effects in the exposed newborns. In animal studies, no effects on embryo fetal development were seen at doses up to 10 mmol/kg/day in rats and 3 mmol/kg/day in rabbits. Based on body surface area, these doses were 16 times the recommended human dose in rats and 10 times in rabbits. The medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: It is not known whether Gadoteric Acid is excreted in human milk. Limited case reports on GBCAs in nursing mothers indicate that 0.01 to 0.04% of the mother's gadolinium dose passes into breast milk. Many drugs are excreted in human milk, so use caution when giving it to a nursing woman. Nonclinical data show that gadoterate meglumine is excreted into breast milk in very small amounts (0.1% of the dose given intravenously), and absorption through the gastrointestinal tract is poor.

If someone has a real overdose of Gadoteric Acid, haemodialysis (blood cleaning) can remove it from the body.

Store Gadoteric Acid at 25°C. If the solution freezes or solidifies in the vial because it has been exposed to cold, bring it to room temperature before use. Left at room temperature for at least 90 minutes, it should go back to a clear solution that is colorless to yellow.

Before you use it, check that all the solids have dissolved and that the container and closure are not damaged. If any solids remain, discard the vial.