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Same active ingredient — pay up to 11% less
These brands contain the same active ingredient (Resmetirom). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Frehepta
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Resmetirom tablets are used together with diet and exercise to treat adults who have noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, consistent with stages F2 to F3 fibrosis.
Pharmacology
Resmetirom is a partial agonist of the thyroid hormone receptor-beta (THR-β). In an in vitro functional assay for THR-β activation, it produced 83.8% of the maximum response seen with triiodothyronine (T3), with an EC50 of 0.21 μM. The same kind of assay for thyroid hormone receptor alpha (THR-α) agonism showed 48.6% efficacy for resmetirom relative to T3, with an EC50 of 3.74 pM. THR-β is the major form of thyroid hormone receptor in the liver, and stimulating it there reduces intrahepatic triglycerides.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dose of Resmetirom depends on the patient's actual body weight. For patients weighing less than 100 kg, the recommended dose is 80 mg taken by mouth once daily. For patients weighing more than 100 kg, the recommended dose is 100 mg taken by mouth once daily. Resmetirom can be taken with or without food.
Side Effects
Resmetirom most often causes diarrhea and nausea. Vomiting, abdominal pain, dizziness, pruritus (itching) and constipation are also common.
Cautions & Contraindications
Warnings & Precautions
Hepatotoxicity Hepatotoxicity has been seen with Resmetirom. The patient needs to be monitored during treatment for rises in liver tests, for liver-related adverse reactions, and for signs and symptoms of hepatotoxicity. If hepatotoxicity is suspected, stop Resmetirom and keep monitoring the patient. If laboratory values return to baseline, weigh the potential risks against the benefits of restarting it. If they don't return to baseline, consider DI-ALH or autoimmune liver disease when evaluating the raised liver tests. Gallbladder-Related Adverse Reactions In clinical trials, cholelithiasis, acute cholecystitis and obstructive pancreatitis (gallstone) were seen in patients treated with Resmetirom. If cholelithiasis is suspected, gallbladder diagnostic studies and appropriate clinical follow-up are indicated. If an acute gallbladder event is suspected, treatment should be interrupted until the event has resolved. Drug Interaction with Certain Statins Exposure to Atorvastatin, Pravastatin, Rosuvastatin and Simvastatin went up when these were given together with Resmetirom, and this may raise the risk of adverse reactions related to those drugs. Dosage adjustment is recommended for certain statins.
Pregnancy & Breastfeeding
Pregnancy
There are no data on the use of Resmetirom in pregnant women, so it isn't possible to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby.
Lactation
Nothing is known about whether Resmetirom passes into human or animal milk, what it might do to a breast-fed infant, or whether it affects milk production. A mother and her doctor should weigh the developmental and health benefits of breastfeeding against her clinical need for Resmetirom. They should also consider any possible harm to the breast-fed infant, either from Resmetirom or from the mother's own underlying condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and effectiveness of Resmetirom have not been established in pediatric patients.
Geriatric use: Patients aged 65 years and older who took Resmetirom showed no difference in effectiveness compared with younger adults. They did have a numerically higher number of adverse reactions.
Renal impairment: The recommended dose for patients with mild or moderate renal impairment is the same as for patients with normal kidney function. Resmetirom has not been studied in patients with severe renal impairment.
Hepatic impairment: Resmetirom should be avoided in patients with decompensated cirrhosis (this is consistent with moderate to severe hepatic impairment). Moderate or severe hepatic impairment (Chiid-Pugh Class B or C) may increase the risk of adverse reactions. For patients with mild hepatic impairment (Child-Pugh Class A), no dose adjustment is recommended.
Storage
Keep Resmetirom below 30°C, in a cool and dry place. Protect it from light. Always keep it out of the reach of children.
Drug Interactions
Common questions about Frehepta 80 mg
What is Frehepta 80 mg Tablet?
Frehepta 80 mg Tablet is a medicine that contains Resmetirom. It is made by Incepta Pharmaceuticals Ltd.
What is Frehepta used for?
Resmetirom tablets are used together with diet and exercise to treat adults who have noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, consistent with stages F2 to F3 fibrosis.
What are the side effects of Frehepta?
Resmetirom most often causes diarrhea and nausea. Vomiting, abdominal pain, dizziness, pruritus (itching) and constipation are also common.
Can I take Frehepta during pregnancy or while breastfeeding?
Pregnancy There are no data on the use of Resmetirom in pregnant women, so it isn't possible to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. Lactation Nothing is known about whether Resmetirom passes into human or animal milk, what it might do to a breast-fed infant, or whether it affects milk production. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Frehepta?
Keep Resmetirom below 30°C, in a cool and dry place. Protect it from light.
Can I take other medicines with Frehepta?
Some medicines can interact with Resmetirom, for example: Cyclosporine, Gemfibrozil, Pioglitazone, Atorvastatin, Rosuvastatin, Clopidogrel. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Lipodes-L by Ziska Pharmaceuticals Ltd. has the same ingredient and strength for ৳40.00 per unit, compared with ৳45.00 for Frehepta. Ask your doctor or pharmacist before switching.
Do I need a prescription for Frehepta?
Frehepta is a prescription (Rx) medicine. Take it as your doctor advises.