Indications & Uses
Fonidel is indicated for:
Pharmacology
Fondaparinux Sodium works against clots by selectively inhibiting Factor Xa. It binds selectively to antithrombin III (ATIII), and this raises (by about 300 times) the natural neutralization of Factor Xa that ATIII already carries out. Once Factor Xa is neutralized, the blood coagulation cascade is interrupted, so thrombin formation and thrombus development are held back.
Fondaparinux Sodium does not inactivate thrombin (activated Factor II), and it has no known effect on platelet function. At the recommended dose, it doesn't affect fibrinolytic activity or bleeding time.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Prophylaxis of deep vein thrombosis: the dose of Fondaparinux is 2.5 mg subcutaneously once daily, given after hemostasis has been established. The first dose should be given no earlier than 6 to 8 hours after surgery, and treatment continues for 5 to 9 days. For patients undergoing hip fracture surgery, extended prophylaxis of up to 24 additional days is recommended.
Treatment of deep vein thrombosis and pulmonary embolism: Fondaparinux is given subcutaneously once daily, and the dose depends on body weight. It is 5 mg for patients under 50 kg (<50 kg), 7.5 mg for 50 to 100 kg, and 10 mg for over 100 kg (>100 kg). Treatment should continue for at least 5 days, until an INR of 2 to 3 is achieved with warfarin sodium.
Pediatric use: the safety and effectiveness of Fondaparinux Sodium in pediatric patients have not been established.
Geriatric use: in clinical trials, Fondaparinux Sodium worked about as well in the elderly (65 years or older) as in patients younger than 65 years, however, serious adverse events increased with age.
Use in renal or hepatic impairment: the risk of bleeding is higher when renal or hepatic function is reduced.
Side Effects
The most common side effects of Fondaparinux Sodium are bleeding complications and mild local irritation after the subcutaneous injection (bleeding at the injection site, rash and pruritus). Other common reactions are anemia, insomnia, hypokalemia, dizziness, hypotension, confusion, bullous eruption, hematoma and post-operative hemorrhage.
Cautions & Contraindications
Warnings & Precautions
Use Fondaparinux Sodium with caution in patients who have conditions that increase the risk of hemorrhage, or who are taking other medicines that do. Bleeding risk is higher in renal impairment and in patients with low body weight (<50 kg). Consider the potential risks and benefits before neuraxial intervention in patients who are anticoagulated, or who are going to be anticoagulated, for thromboprophylaxis. Thrombocytopenia can occur when Fondaparinux Sodium is given. Periodic routine complete blood counts (including platelet counts), serum creatinine level and stool occult blood tests are recommended.
Contraindications
Fondaparinux Sodium must not be used in people with severe renal impairment (creatinine clearance <30 mL/min), active major bleeding, bacterial endocarditis or thrombocytopenia. It is also contraindicated when body weight is <50 kg, but this applies to venous thromboembolism (VTE) prophylaxis only. And anyone with a history of serious hypersensitivity reaction to Fondaparinux Sodium should not take it.
Pregnancy & Breastfeeding
Fondaparinux sodium is Pregnancy Category B. Nobody knows yet whether it passes into human breast milk, so a nursing mother should be given Fondaparinux Sodium with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Fondaparinux Sodium below 25° C. Don't let it freeze. As with all medicines, keep it out of reach of children.
Common questions about Fonidel 2.5 mg/0.5 ml
What is Fonidel 2.5 mg/0.5 ml Ophthalmic Solution?
Fonidel 2.5 mg/0.5 ml Ophthalmic Solution is a medicine that contains Fondaparinux Sodium. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Parenteral anti-coagulants group of medicines.
What is Fonidel used for?
Fonidel is used for: Deep Vein Thrombosis.
What are the side effects of Fonidel?
The most common side effects of Fondaparinux Sodium are bleeding complications and mild local irritation after the subcutaneous injection (bleeding at the injection site, rash and pruritus). Other common reactions are anemia, insomnia, hypokalemia, dizziness, hypotension, confusion, bullous eruption, hematoma and post-operative hemorrhage.
Can I take Fonidel during pregnancy or while breastfeeding?
Fondaparinux sodium is Pregnancy Category B. Nobody knows yet whether it passes into human breast milk, so a nursing mother should be given Fondaparinux Sodium with caution. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Fonidel?
Keep Fondaparinux Sodium below 25° C. Don't let it freeze.
Do I need a prescription for Fonidel?
Fonidel is a prescription (Rx) medicine. Take it as your doctor advises.