Pricing
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All price changes →Indications & Uses
Fludin is indicated for:
Pharmacology
Trifluridine is a fluorinated pyrimidine nucleoside analog that interferes with DNA synthesis in herpes simplex virus types 1 and 2, as well as vaccinia virus. It halts replication of the viral DNA through 3 mechanisms: competitive inhibition of viral DNA polymerase, incorporation into the growing viral DNA chain leading to its termination, and inactivation of the viral DNA polymerase.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Children over 6 years of age and adults: Instil 1 drop every 2 hours while awake, up to a maximum of 9 drops per day, until the corneal ulcer has completely re-epithelialised. After re-epithelialisation, instil 1 drop every 4 hours, or at least 5 drops per day, for 7 days. If there are no signs of improvement after 7 days of treatment, or if complete re-epithelialisation has not occurred after 14 days, other forms of treatment should be considered. Continuous use of Fludin eye drops for more than 21 days should be avoided because of the potential for ocular toxicity.
Use in children: Safety and effectiveness in children under 6 years of age have not been established.
Use in elderly patients: No overall differences in safety or effectiveness have been observed between elderly patients and other adults.
Side Effects
The most commonly reported side effect is a mild, short-lived burning or stinging sensation when the drops are put into the eye. Other side effects that have been reported include superficial punctate keratopathy, epithelial keratopathy, hypersensitivity reactions, stromal oedema, irritation, keratitis sicca (dry eye), hyperaemia (redness) and raised intraocular pressure.
Cautions & Contraindications
Warnings & Precautions
Fludin should only be prescribed for patients who have been clinically diagnosed with herpetic keratitis.
Contraindications
Do not use in patients with a known hypersensitivity to Trifluridine, or in those who have shown chemical intolerance to it.
Pregnancy & Breastfeeding
Pregnancy category C. No adequate, well-controlled studies have been conducted in pregnant women, so Trifluridine should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby.
Regarding breastfeeding, Trifluridine is unlikely to pass into human breast milk after the eye drops are instilled, since the dose absorbed is relatively small. Even so, it should not be given to breastfeeding mothers unless the potential benefits outweigh the potential risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Trifluridine in a refrigerator at 2 to 8°C. Once you have opened the bottle, don't use it for longer than 30 days. Keep it out of the reach of children.
Drug Interactions
Common questions about Fludin 1%
What is Fludin 1% Ophthalmic Solution?
Fludin 1% Ophthalmic Solution is a medicine that contains Trifluridine. It is made by Aristopharma Limited. It belongs to the Ophthalmic Anti-viral Products group of medicines.
What is Fludin used for?
Fludin is used for: Viral Infection.
What are the side effects of Fludin?
The most commonly reported side effect is a mild, short-lived burning or stinging sensation when the drops are put into the eye. Other side effects that have been reported include superficial punctate keratopathy, epithelial keratopathy, hypersensitivity reactions, stromal oedema, irritation, keratitis sicca (dry eye), hyperaemia (redness) and raised intraocular pressure.
Can I take Fludin during pregnancy or while breastfeeding?
Pregnancy category C. No adequate, well-controlled studies have been conducted in pregnant women, so Trifluridine should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Fludin?
Keep Trifluridine in a refrigerator at 2 to 8°C. Once you have opened the bottle, don't use it for longer than 30 days.
Can I take other medicines with Fludin?
Some medicines can interact with Trifluridine, for example: Trifluridine + Tipiracil. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Fludin?
Fludin is a prescription (Rx) medicine. Take it as your doctor advises.