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Indications & Uses
Pharmacology
Flucloxacillin is active against Gram-positive organisms, including strains that produce penicillinase, though it has little effect on Gram-negative bacilli. It works by blocking formation of the bacterial cell wall. As an isoxazolyl penicillin, it combines resistance to breakdown by penicillinase with stability in stomach acid and activity against Gram-positive bacteria, making it a bactericidal antibiotic that is especially useful against penicillinase-producing staphylococci.
More specifically, Flucloxacillin disrupts the bacterial cell wall by interfering with the synthesis of peptidoglycan, the heteropolymeric structure that gives the cell wall its mechanical strength. The final step of peptidoglycan synthesis is the cross-linking of the terminal glycine residue of the pentaglycine bridge to the fourth residue (D-alanine) of the pentapeptide, a step carried out by the transpeptidase enzyme. Flucloxacillin inhibits this enzyme, so the cell wall is weakened and the bacterial cell swells and eventually ruptures. It is thought to resist bacterial penicillinase because of steric hindrance from its acyl side chain, which prevents the beta-lactam ring from being opened.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
Oral administration: Adults take 250 mg four times daily. The dose may be doubled in severe infections. For osteomyelitis and endocarditis, up to 8 gm daily is used in divided doses given every 6 to 8 hours. Children aged 2 to 10 years are given half the adult dose, and children under 2 years are given a quarter of the adult dose.
Parenteral administration: Adults and elderly patients may receive 250 mg four times daily by intramuscular injection. By intravenous injection, 250 mg to 1 g is given four times daily, either as a slow injection over 3 to 4 minutes or by intravenous infusion. All systemic doses may be doubled in severe infections, and doses of up to 8 g daily have been suggested for endocarditis or osteomyelitis. Children aged 2 to 10 years are given half the adult dose, and children under 2 years are given a quarter of the adult dose.
Side Effects
Nausea, vomiting, diarrhoea, indigestion and other minor stomach upsets are among the side effects people have noticed with flucloxacillin. Rashes, hives, purple spots on the skin, fever, inflammation of the kidneys (interstitial nephritis), liver inflammation (hepatitis) and a yellowing of the skin and eyes from bile blockage (cholestatic jaundice) have also been reported.
Cautions & Contraindications
Warnings & Precautions
S-Fluclox should be used carefully in patients with signs of liver problems. It should also be used with caution when treating patients who have a tendency toward allergic reactions.
Contraindications
Flucloxacillin should not be used in patients who are hypersensitive to penicillin.
Pregnancy & Breastfeeding
Pregnancy and Breastfeeding: Flucloxacillin falls under US FDA Pregnancy Category B. There are no adequate, well-controlled studies of its use in pregnant women, and because animal studies don't always predict how humans will respond, it should only be used during pregnancy when clearly necessary. Flucloxacillin also passes into breast milk, so it should be given to breastfeeding mothers with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
If a patient has severe renal failure (creatinine clearance below 10 ml/min), the doctor should consider giving Flucloxacillin Sodium at a lower dose or leaving a longer gap between doses.
Storage
Store Flucloxacillin Sodium in a dry place, away from light and heat. Always keep it out of the reach of children.
Common questions about Floxason 125 mg/5 ml
What is Floxason 125 mg/5 ml Powder For Suspension?
Floxason 125 mg/5 ml Powder For Suspension is a medicine that contains Flucloxacillin Sodium. It is made by Hudson Pharmaceuticals Ltd. It belongs to the Narrow spectrum penicillin group of medicines.
What is Floxason used for?
Floxason is used for: Pneumonia, Sinusitis, Pharyngitis, Tonsillitis, Urinary Tract Infection, Respiratory Tract Infection, Skin and Soft Tissue Infection, Sepsis, Otitis Media, Acne Vulgaris.
What are the side effects of Floxason?
Nausea, vomiting, diarrhoea, indigestion and other minor stomach upsets are among the side effects people have noticed with flucloxacillin. Rashes, hives, purple spots on the skin, fever, inflammation of the kidneys (interstitial nephritis), liver inflammation (hepatitis) and a yellowing of the skin and eyes from bile blockage (cholestatic jaundice) have also been reported.
Can I take Floxason during pregnancy or while breastfeeding?
Pregnancy and Breastfeeding: Flucloxacillin falls under US FDA Pregnancy Category B. There are no adequate, well-controlled studies of its use in pregnant women, and because animal studies don't always predict how humans will respond, it should only be used during pregnancy when clearly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Floxason?
Store Flucloxacillin Sodium in a dry place, away from light and heat. Always keep it out of the reach of children.
Do I need a prescription for Floxason?
Floxason is a prescription (Rx) medicine. Take it as your doctor advises.