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Indications & Uses
Safinamide Mesylate is a monoamine oxidase type B (MAO-B) inhibitor. Doctors use it as an add-on treatment alongside levodopa/carbidopa for people with Parkinson's disease who experience "off" episodes. It has not been shown to work when used alone, so it is not a treatment for Parkinson's disease on its own.
Pharmacology
Nobody knows exactly how Safinamide Mesylate works in Parkinson's disease. What is known is that it inhibits monoamine oxidase B (MAO-B). By blocking the breakdown of dopamine, this inhibition is thought to raise dopamine levels and so increase dopaminergic activity in the brain.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Usual Initial Dosage
The recommended starting dosage of Safinamide tablet is 50 mg taken by mouth once daily, at the same time each day. If you miss a dose, take the next one at the same time the next day.
Maintenance Dosage
After 2 weeks, the dose may be raised to 100 mg once daily, depending on the person's need and how well they tolerate it. Before stopping Safinamide 100 mg, the dose should be tapered by reducing it to 50 mg for one week.
Use in Children
Safety and effectiveness of Safinamide in infants and children have not been established.
Geriatric Use
Older patients showed no overall differences in safety or effectiveness compared with younger patients.
Hepatic Impairment
Safinamide plasma concentrations are increased in patients with hepatic impairment.
Side Effects
The most common side effects of Safinamide Mesylate are dyskinesia, falls, nausea and insomnia.
Cautions & Contraindications
Warnings & Precautions
Safinamide Mesylate may cause hypertension or make it worse. It may cause serotonin syndrome when it is used with MAO inhibitors, antidepressants or opioid drugs. Some people may fall asleep during activities of daily living. Dyskinesia can start or get worse, and a lower levodopa dose should be considered if that happens. Hallucinations and psychotic behaviour may also occur, as may problems with impulse control and compulsive behaviours. Withdrawal-emergent hyperpyrexia and confusion are possible too.
Contraindications
Safinamide is contraindicated in patients with any of the following. Concomitant use of these drugs: other monoamine oxidase inhibitors or other drugs that are potent inhibitors of monoamine oxidase (e.g., linezolid); opioid drugs (e.g., tramadol, meperidine and related derivatives); selective norepinephrine reuptake inhibitors; tri- or tetra-cyclic or triazolopyridine antidepressants; cyclobenzaprine; methylphenidate, amphetamine, and their derivatives; St. John's wort; and dextromethorphan. A history of hypersensitivity to safinamide. Severe hepatic impairment (Child-Pugh C: 10-15).
Pregnancy & Breastfeeding
Safinamide Mesylate (XADAGO) is Pregnancy Category C. There are no adequate and well-controlled studies of XADAGO in pregnant women. In animals, developmental toxicity, including teratogenic effects, was seen when safinamide was given during pregnancy at clinically relevant doses.
Rat pups that were exposed to safinamide indirectly, through the milk during the lactation period, showed skin discoloration. This was presumed to be caused by hyperbilirubinemia resulting from hepatobiliary toxicity.
It is not known whether the drug is present in human milk. Many drugs are excreted in human milk, and safinamide could cause serious adverse reactions in nursing infants. So a decision should be made whether to stop nursing or to stop the drug, taking into account how important the drug is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No one has reported experience of a Safinamide Mesylate overdose in humans. If a serious overdose does happen, stop the Safinamide Mesylate treatment and give supportive treatment as the clinical situation needs. The person should also avoid tyramine in the diet for several weeks.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Safinamide Mesylate below 30°C and away from light. Keep it out of the reach of children.
Common questions about Finapark 50 mg
What is Finapark 50 mg Tablet?
Finapark 50 mg Tablet is a medicine that contains Safinamide Mesylate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Antiparkinson drugs group of medicines.
What is Finapark used for?
Safinamide Mesylate is a monoamine oxidase type B (MAO-B) inhibitor. Doctors use it as an add-on treatment alongside levodopa/carbidopa for people with Parkinson's disease who experience "off" episodes.
What are the side effects of Finapark?
The most common side effects of Safinamide Mesylate are dyskinesia, falls, nausea and insomnia.
Can I take Finapark during pregnancy or while breastfeeding?
Safinamide Mesylate (XADAGO) is Pregnancy Category C. There are no adequate and well-controlled studies of XADAGO in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Finapark?
No one has reported experience of a Safinamide Mesylate overdose in humans. If a serious overdose does happen, stop the Safinamide Mesylate treatment and give supportive treatment as the clinical situation needs. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Finapark?
Store Safinamide Mesylate below 30°C and away from light. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Finapark is already among the lowest-priced brands of Safinamide Mesylate at this strength.
Do I need a prescription for Finapark?
Finapark is a prescription (Rx) medicine. Take it as your doctor advises.