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Fenazine is prescribed for the long-term management of psychotic disorders, including schizophrenia, mania, and organic brain syndrome.
Pharmacology
Fluphenazine decanoate works by blocking dopamine D1 and D2 receptors after the synapse in the brain's mesolimbic pathway, and it also cuts down the release of hypothalamic and pituitary hormones. This action brings on a sense of calm, eases aggressive behaviour, and clears away hallucinations and delusions. As a derivative of the phenothiazine group, fluphenazine decanoate is a highly potent antipsychotic given by intramuscular injection, valued for how long its effects last. Attaching decanoic acid to the fluphenazine molecule through esterification is what stretches out this duration of action, and it does so without making the drug any less effective.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Fluphenazine Decanoate is given by deep intramuscular injection into the gluteal muscle. A test dose of 12.5 mg is given first (6.25 mg in the elderly), then, after 4 to 7 days, 12.5 to 100 mg is given at intervals of 14 to 35 days, adjusted according to response. It is not recommended for children.
Side Effects
Tardive dyskinesia, sedation, and mental confusion can occur, along with a drop in blood pressure. By raising prolactin levels, the medicine may cause galactorrhoea and amenorrhoea in women, and reduced libido, impotence, or sterility in men. Allergic reactions, cholestatic jaundice, deposits in the cornea and lens, and skin pigmentation are also seen. Less commonly, it may lead to agranulocytosis or neuroleptic malignant syndrome.
Cautions & Contraindications
Warnings & Precautions
Special caution is needed for patients with convulsive disorders or hepatic, renal, cerebrovascular, respiratory, or cardiovascular disease. Caution should also be used in pheochromocytoma, bone marrow suppression, and in elderly or debilitated patients.
Contraindications
Fluphenazine Decanoate oily injection should not be used in patients known to be hypersensitive to it. It should also be avoided in those who are comatose or in a state of severe depression, as well as in patients with blood disorders (blood dyscrasias) or liver disease. It should not be used during the 3rd trimester of pregnancy or while breastfeeding.
Pregnancy & Breastfeeding
Safety during pregnancy has not been established for Fluphenazine decanoate, so it should only be given to pregnant patients after weighing the potential benefits against the possible risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If too much Fluphenazine Decanoate is taken, the signs can include muscle weakness, an irregular heart rhythm and difficulty in breathing.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Fluphenazine Decanoate in a cool, dry place, below 30°C, and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Fenazine 25 mg/ml
What is Fenazine 25 mg/ml IM/SC Injection?
Fenazine 25 mg/ml IM/SC Injection is a medicine that contains Fluphenazine Decanoate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Phenothiazine drugs group of medicines.
What is Fenazine used for?
Fenazine is prescribed for the long-term management of psychotic disorders, including schizophrenia, mania, and organic brain syndrome.
What are the side effects of Fenazine?
Tardive dyskinesia, sedation, and mental confusion can occur, along with a drop in blood pressure. By raising prolactin levels, the medicine may cause galactorrhoea and amenorrhoea in women, and reduced libido, impotence, or sterility in men.
Can I take Fenazine during pregnancy or while breastfeeding?
Safety during pregnancy has not been established for Fluphenazine decanoate, so it should only be given to pregnant patients after weighing the potential benefits against the possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Fenazine?
If too much Fluphenazine Decanoate is taken, the signs can include muscle weakness, an irregular heart rhythm and difficulty in breathing. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Fenazine?
Keep Fluphenazine Decanoate in a cool, dry place, below 30°C, and away from light. Keep it out of the reach of children.
Can I take other medicines with Fenazine?
Some medicines can interact with Fluphenazine Decanoate, for example: Clonidine Hydrochloride, Methyldopa. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Fenazine?
Fenazine is a prescription (Rx) medicine. Take it as your doctor advises.