More from Fedrin
Other strengths and forms by Jayson Pharmaceuticals Ltd.
Indications & Uses
Asmaphen is used to correct low blood pressure caused by spinal or epidural anaesthesia. It is of limited benefit in hypotensive crises arising from shock, circulatory collapse, or haemorrhage.
Pharmacology
Ephedrine belongs to a class of medicines called sympathomimetics, meaning it stimulates the body in ways similar to the "fight-or-flight" hormones. It acts directly on both alpha and beta adrenergic receptors, and it also prompts the body to release more of its own norepinephrine, a naturally occurring hormone that strongly activates alpha receptors. In this way, ephedrine works much like epinephrine (adrenaline), the body's main adrenergic hormone, which similarly acts on both alpha and beta receptors. Once taken, ephedrine heightens activity in the central nervous system and also produces a stimulating effect on other tissues throughout the body.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Ephedrine Hydrochloride is used to reverse low blood pressure caused by spinal or epidural anaesthesia. In adults, the usual approach is a slow intravenous injection of 3 to 6 mg (up to 9 mg at most), which may be repeated every 3 to 4 minutes as needed, up to a maximum total dose of 30 mg. It may also be given by intramuscular or subcutaneous injection.
Side Effects
Adverse effects that have been reported include nausea, vomiting, and loss of appetite. Effects on the heart and circulation include a fast heartbeat (occasionally a slow one), irregular heartbeat, chest pain, narrowing of blood vessels with raised blood pressure, or widening of blood vessels with lowered blood pressure, along with dizziness and flushing. Breathlessness may also occur. Other reported effects include headache, anxiety, restlessness, confusion, psychotic reactions, insomnia, and tremor; difficulty passing urine or retaining urine; sweating and excessive salivation; and changes in blood-glucose levels. Very rarely, it may trigger angle-closure glaucoma.
Cautions & Contraindications
Warnings & Precautions
Asmaphen should be used cautiously in patients with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, or angle-closure glaucoma. In men with an enlarged prostate, it may make urination more difficult. During pregnancy and breastfeeding: injectable Asmaphen has been linked to a faster fetal heart rate, and breast-fed infants of mothers taking it have shown irritability and disturbed sleep.
Contraindications
Ephedrine should not be used by anyone with coronary thrombosis. It should also be used carefully in patients who have organic heart disease, cardiac decompensation, hyperthyroidism, high blood pressure, or angina pectoris, as well as in those who are taking digitalis.
Pregnancy & Breastfeeding
Pregnancy: Category C. In animal studies, adverse effects have been seen on the foetus (such as teratogenic or embryocidal effects), and controlled studies in pregnant women are not available, or studies in both women and animals have not been done. This medicine should be given only if the potential benefit justifies the potential risk to the foetus.
Lactation: Ephedrine Hydrochloride passes into breast milk. For this reason, Ephedrine Hydrochloride Injection is not recommended during lactation, due to the risk of adverse effects in the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Most patients who take large enough doses of Ephedrine Hydrochloride get some minor reactions: giddiness, headache, nausea, vomiting, sweating, palpitations, difficulty in micturition, tremors, anxiety, restlessness and insomnia. Some patients may show these same symptoms even at the usual therapeutic dose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Ephedrine Hydrochloride in a cool, dry place and away from light. As with all medicines, keep it out of reach of children.
Drug Interactions
Common questions about Fedrin 25 mg
What is Fedrin 25 mg Injection?
Fedrin 25 mg Injection is a medicine that contains Ephedrine Hydrochloride. It is made by Jayson Pharmaceuticals Ltd. It belongs to the Other adrenoceptor stimulants group of medicines.
What is Fedrin used for?
Asmaphen is used to correct low blood pressure caused by spinal or epidural anaesthesia. It is of limited benefit in hypotensive crises arising from shock, circulatory collapse, or haemorrhage.
What are the side effects of Fedrin?
Adverse effects that have been reported include nausea, vomiting, and loss of appetite. Effects on the heart and circulation include a fast heartbeat (occasionally a slow one), irregular heartbeat, chest pain, narrowing of blood vessels with raised blood pressure, or widening of blood vessels with lowered blood pressure, along with dizziness and flushing.
Can I take Fedrin during pregnancy or while breastfeeding?
Pregnancy: Category C. In animal studies, adverse effects have been seen on the foetus (such as teratogenic or embryocidal effects), and controlled studies in pregnant women are not available, or studies in both women and animals have not been done. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Fedrin?
Most patients who take large enough doses of Ephedrine Hydrochloride get some minor reactions: giddiness, headache, nausea, vomiting, sweating, palpitations, difficulty in micturition, tremors, anxiety, restlessness and insomnia. Some patients may show these same symptoms even at the usual therapeutic dose. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Fedrin?
Keep Ephedrine Hydrochloride in a cool, dry place and away from light. As with all medicines, keep it out of reach of children.
Can I take other medicines with Fedrin?
Some medicines can interact with Ephedrine Hydrochloride, for example: Halothane, Oxytocin, Dexamethasone, Doxophylline, Dexamethasone + Chloramphenicol, Betamethasone. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Fedrin?
Fedrin is a prescription (Rx) medicine. Take it as your doctor advises.