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These brands contain the same active ingredient (Febuxostat). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Febux
Other strengths and forms by Aristopharma Limited
Indications & Uses
Febux is indicated for:
Pharmacology
Febuxostat is a non-purine medicine that works by selectively blocking an enzyme called xanthine oxidase. This enzyme is normally responsible for breaking down hypoxanthine into xanthine, and then xanthine into uric acid. By inhibiting xanthine oxidase, febuxostat reduces the body's production of uric acid, thereby lowering serum uric acid levels. At the doses used for treatment, it is not expected to affect other enzymes involved in the synthesis and breakdown of purines and pyrimidines.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended starting dose is one Febuxostat 40 mg tablet once daily. For patients who do not achieve a serum uric acid level below 6 mg per dL after 2 weeks on Febuxostat 40 mg tablet, one Febuxostat 80 mg tablet once daily is recommended. If serum uric acid remains below 6 mg per dL after 2 to 4 weeks on Xanuric 80 (Febuxostat 80mg) tablet, then one Febuxostat 120 mg tablet once daily is recommended.
For Tumor Lysis Syndrome, the recommended dose is one Febuxostat 120 mg tablet once daily. The Febuxostat 120 mg tablet should be started two days before beginning cytotoxic therapy and continued for a minimum of 7 days. Treatment may, however, be prolonged up to 9 days depending on the duration of chemotherapy, based on clinical judgment.
Regarding gout flares, these may occur after starting Feboxostat tablets because changing serum uric acid levels can mobilize urate from tissue deposits. Flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended when starting Febuxostat tablets. If a gout flare occurs during treatment, Feboxostat tablets need not be discontinued; the flare should be managed concurrently, as appropriate for the individual patient.
In renal impairment, no dose adjustment is necessary when giving Febuxostat to patients with mild to moderate renal impairment. In hepatic impairment, no dose adjustment is necessary in patients with mild to moderate hepatic impairment.
For pediatric use, safety and effectiveness in patients under 18 years of age have not been established.
Side Effects
Gout flares, changes in liver function tests, diarrhoea, nausea, headache, rash and swelling were the most commonly reported side effects, generally mild to moderate in severity. Rare but serious allergic reactions to Feluric have also been observed.
Cautions & Contraindications
Warnings & Precautions
Gout Flare: An increase in gout flares is often observed when starting anti-hyperuricemic agents, including Feluric. If a gout flare occurs during treatment, Feluric does not need to be stopped. Preventive therapy (i.e., a non-steroidal anti-inflammatory drug (NSAID) or colchicine started along with treatment) may be helpful for up to six months. Cardiovascular Events: In clinical trials, patients treated with Feluric had a higher rate of cardiovascular thromboembolic events than those treated with allopurinol. Watch for signs and symptoms of heart attack and stroke. Liver Enzyme Elevation: Elevations in liver enzymes have been observed in patients treated with Feluric. Liver function tests should be monitored periodically.
Contraindications
Febuxostat should not be used by patients who are on azathioprine, mercaptopurine, or theophylline.
Pregnancy & Breastfeeding
Pregnancy Category C. No adequate, well-controlled studies have looked at Febuxostat's use in pregnant women, so it should only be given during pregnancy if the potential benefit is felt to outweigh the potential risk to the unborn child. Whether the drug passes into human breast milk is not known, so it should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Febustat (febuxostat) was studied in healthy subjects at doses of up to 300 mg daily for seven days, and no dose-limiting toxicities were seen.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Febuxostat below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Febux 40 mg
What is Febux 40 mg Tablet?
Febux 40 mg Tablet is a medicine that contains Febuxostat. It is made by Aristopharma Limited. It belongs to the Drugs used in Gout group of medicines.
What is Febux used for?
Febux is used for: Gout.
What are the side effects of Febux?
Gout flares, changes in liver function tests, diarrhoea, nausea, headache, rash and swelling were the most commonly reported side effects, generally mild to moderate in severity. Rare but serious allergic reactions to Feluric have also been observed.
Can I take Febux during pregnancy or while breastfeeding?
Pregnancy Category C. No adequate, well-controlled studies have looked at Febuxostat's use in pregnant women, so it should only be given during pregnancy if the potential benefit is felt to outweigh the potential risk to the unborn child. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Febux?
Febustat (febuxostat) was studied in healthy subjects at doses of up to 300 mg daily for seven days, and no dose-limiting toxicities were seen. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Febux?
Store Febuxostat below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Febux?
Some medicines can interact with Febuxostat, for example: Mercaptopurine, Azathioprine, Hydrochlorothiazide, Rosiglitazone, Naproxen, Indomethacin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Febulas by Delta Pharma PLC. has the same ingredient and strength for ৳8.00 per unit, compared with ৳11.00 for Febux. Ask your doctor or pharmacist before switching.
Do I need a prescription for Febux?
Febux is a prescription (Rx) medicine. Take it as your doctor advises.