More from Estellis
Other strengths and forms by Renata PLC
Indications & Uses
Drospirenone + Estetrol is a contraceptive for women who are able to become pregnant. It is used to prevent pregnancy.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dosage of Drospirenone + Estetrol is one tablet daily for 28 consecutive days. Take one pink active tablet daily at the same time during the first 24 days, then one white inactive tablet daily during the 4 following days.
Instruction for missed doses
If one pink active tablet is missed, take it as soon as possible and take the next tablet at the scheduled time, even if that means two active tablets in one day. Continue taking one tablet a day until the pack is finished.
If two or more pink active tablets are missed in Week 1 or Week 2, take one of the missed tablets as soon as possible, then take the tablet for the current day (that means two tablets in one day). Discard the other missed tablets. Continue taking one tablet a day until the pack is finished. Use additional non-hormonal contraception as back-up until pink tablets have been taken for 7 consecutive days.
If two pink active tablets are missed in Week 3, take one of the missed tablets as soon as possible, then take the tablet for the current day (that means two tablets in one day). Discard the other missed tablets. Finish the active tablets and discard the inactive tablets in the pack, then start a new pack the next day. Use additional non-hormonal contraception as back-up until pink tablets have been taken for 7 consecutive days.
If one or more white inert tablets are missed, skip the missed pill days and continue taking one tablet a day until the pack is finished.
Administration recommendations after vomiting or acute diarrhea
If vomiting or acute diarrhea occurs within 3 to 4 hours after taking an active tablet, take the new active tablet (the one scheduled for the next day) as soon as possible. If you can, take it within 12 hours of the usual time of tablet-taking. If more than two tablets are missed, follow the advice for missed tablets, including the use of back-up non-hormonal contraception.
Side Effects
The most common side effects of Drospirenone + Estetrol, seen in 2% or more of users, are bleeding irregularities, mood disturbance, headache and breast symptoms. Dysmenorrhea, acne, weight increased and decreased libido are also commonly reported.
Cautions & Contraindications
Warnings & Precautions
Thromboembolic Disorders and Other Vascular Problems Stop LIANA if a thrombotic or thromboembolic event occurs. Don't start it earlier than 4 weeks after delivery. Look at all the cardiovascular risk factors before starting LIANA in any female, and take particular care when there are multiple risk factors. Hyperkalemia In females on long-term treatment with medicines that may raise serum potassium, check the serum potassium concentration during the first LIANA treatment cycle. Hypertension Monitor blood pressure from time to time. Stop LIANA if blood pressure rises significantly. Migraine Discontinue LIANA if new, recurrent, persistent or severe migraines occur. Hormonally Sensitive Malignancy If a hormonally sensitive malignancy is diagnosed, discontinue LIANA. Liver Disease Withhold LIANA or stop it permanently if liver enzymes stay raised or rise significantly. Glucose Tolerance and Hypertriglyceridemia Monitor glucose in females with prediabetes or diabetes. For females with hypertriglyceridemia, consider another contraceptive method. Gallbladder Disease and Cholestasis In females with symptomatic gallbladder or cholestatic disease, consider discontinuing LIANA. Bleeding Irregularities and Amenorrhea LIANA may cause irregular bleeding or amenorrhea. If these symptoms persist, look for other causes.
Contraindications
Drospirenone + Estetrol is contraindicated in females who develop, or are known to have, a high risk of arterial or venous thrombotic diseases, a current or past hormonally-sensitive malignancy (for example, breast cancer), hepatic adenoma, hepatocellular carcinoma, acute hepatitis or decompensated cirrhosis. It is also contraindicated when taken together with hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir. Abnormal uterine bleeding with an undiagnosed cause, renal impairment and adrenal insufficiency are contraindications as well.
Pregnancy & Breastfeeding
Stop taking Drospirenone + Estetrol if pregnancy occurs, as there is no reason to use hormonal contraceptives during pregnancy. The contraceptive hormones and/or their metabolites pass into human milk. COCs can also reduce milk production in breast-feeding women. This can happen at any time, but it is less likely once breast-feeding is well established. When possible, a nursing woman should be advised to use other methods of contraception until she stops breast-feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
LIANA has been shown to be safe and effective in females who can become pregnant. It is not indicated for use before menarche.
Geriatric Use
LIANA has not been studied in postmenopausal females, and it is not indicated for them.
Overdose
Taking too much of a combined hormonal contraceptive (CHC) can cause nausea, vomiting and severe headaches. There have been individual reports of thromboembolic complications and vaginal bleeding after an overdose. When children have swallowed a CHC by accident, they have reported nausea and vomiting, and some became irritable and drowsy. Vaginal bleeding was described in rare cases.
Overdosage Management Recommendations
For patients at high risk of VTE, consider short-term prophylactic anticoagulation therapy. Monitor serum potassium and sodium levels, and watch for signs of metabolic acidosis.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Drospirenone + Estetrol at 20°C to 25°C, in a place free from frost. Keep it away from light. Temperatures from 15°C to 30°C are permitted for short periods. Keep it out of the reach of children.
Common questions about Estellis 3 mg+14.2 mg
What is Estellis 3 mg+14.2 mg Tablet?
Estellis 3 mg+14.2 mg Tablet is a medicine that contains Drospirenone + Estetrol. It is made by Renata PLC. It belongs to the Oral Contraceptive preparations group of medicines.
What is Estellis used for?
Drospirenone + Estetrol is a contraceptive for women who are able to become pregnant. It is used to prevent pregnancy.
What are the side effects of Estellis?
The most common side effects of Drospirenone + Estetrol, seen in 2% or more of users, are bleeding irregularities, mood disturbance, headache and breast symptoms. Dysmenorrhea, acne, weight increased and decreased libido are also commonly reported.
Can I take Estellis during pregnancy or while breastfeeding?
Stop taking Drospirenone + Estetrol if pregnancy occurs, as there is no reason to use hormonal contraceptives during pregnancy. The contraceptive hormones and/or their metabolites pass into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Estellis?
Taking too much of a combined hormonal contraceptive (CHC) can cause nausea, vomiting and severe headaches. There have been individual reports of thromboembolic complications and vaginal bleeding after an overdose. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Estellis?
Store Drospirenone + Estetrol at 20°C to 25°C, in a place free from frost. Keep it away from light.
Do I need a prescription for Estellis?
Estellis is a prescription (Rx) medicine. Take it as your doctor advises.