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These brands contain the same active ingredient (Levamlodipine Maleate). Same strength and form. Confirm the switch with your doctor or pharmacist.
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Other strengths and forms by Renata PLC
Indications & Uses
Levamlodipine Maleate is a calcium channel blocker. Doctors prescribe it for hypertension, to lower blood pressure, and it can be used alone or together with other antihypertensive agents. Bringing blood pressure down reduces the risk of fatal and nonfatal cardiovascular events, mainly strokes and myocardial infarctions.
Pharmacology
Levamlodipine is used to treat hypertension, to lower blood pressure, in adults and in children aged 6 years and older. Amlodipine is a dihydropyridine calcium antagonist (also called a calcium ion antagonist or slow channel blocker). It stops calcium ions from moving across the cell membrane into vascular smooth muscle and cardiac muscle. This effect is selective, and it is greater on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a 1:1 racemic mixture of levamlodipine and dextro amlodipine, and levamlodipine has been shown to be the pharmacologically active, anti-hypertensive isomer.
Absorption: Taken by mouth, levamlodipine has a Tmax of 6 to 12 h and a bioavailability of 64 to 90%. Food does not significantly affect its absorption.
Distribution: The volume of distribution of levamlodipine is similar to that of amlodipine, which is 21 L/kg.
Metabolism and Excretion: About 90% of levamlodipine is metabolized to inactive metabolites. Tests with liver microsomes showed that this metabolism is mainly mediated by CYP3A4. The derivative can be oxidatively deaminated or O-dealkylated further, but it doesn't seem to undergo O-demethylation the way racemic amlodipine does. Levamlodipine is 60% eliminated in urine, and 10% is eliminated as the unmetabolized drug.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Levamlodipine is taken by mouth.
Dosage: for high blood pressure, the usual starting oral dose of Levamlodipine is 2.5 mg once daily, and the maximum dose is 5 mg once daily.
Adult and elderly patients: elderly patients, or those with hepatic insufficiency, may be started on 1.25 mg once daily. The same dose may be used when Levamlodipine is added to other antihypertensive therapy. The dosage needs to be adjusted according to blood pressure goals, with a waiting period of 7 to 14 days between titration steps. Titration needs to be done more rapidly if clinically warranted, provided the patient is assessed frequently.
Use in children and adolescents: the effective antihypertensive oral dose in pediatric patients aged 6 to 17 years is 1.25 mg to 2.5 mg once daily. Doses above 2.5 mg daily have not been studied in pediatric patients.
Side Effects
Common side effects of Levamlodipine Maleate are difficulty in breathing, dizziness, reflex tachycardia, hypotension, abdominal pain and edema. Rare ones are diarrhea, back pain, headache, fatigue and nausea.
Cautions & Contraindications
Warnings & Precautions
Hypotension Symptomatic hypotension is possible with levamlodipine maleate, particularly in patients with severe aortic stenosis. The effect comes on gradually, so a sudden fall in blood pressure is unlikely. Increased angina or myocardial infarction Angina can get worse, and acute myocardial infarction can develop, after amlodipine is started or the dose is increased. This is more likely in patients with severe obstructive coronary artery disease. Patients with hepatic failure Amlodipine is broken down largely by the liver, and in patients with impaired liver function its plasma elimination half-life (t½) is 56 hours. So when amlodipine is given to a patient with severe hepatic impairment, the dose should be increased slowly.
Contraindications
Levamlodipine Maleate (S-amlodipine) must not be given to anyone who is already known to be sensitive to amlodipine.
Pregnancy & Breastfeeding
There isn't much post-marketing data on amlodipine use in pregnant women, and what exists isn't enough to say whether the medicine carries a risk of major birth defects or miscarriage. For breastfeeding, no adverse effects of amlodipine have been seen in the breastfed infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of levamlodipine maleate would be expected to cause widespread widening of the blood vessels, with a marked fall in blood pressure and possibly a fast heartbeat as a reflex response.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Levamlodipine Maleate in a cool, dry place, away from light and moisture. And keep all medicines out of reach of children.
Drug Interactions
Common questions about Esodip 5 mg
What is Esodip 5 mg Tablet?
Esodip 5 mg Tablet is a medicine that contains Levamlodipine Maleate. It is made by Renata PLC. It belongs to the Calcium-channel blockers group of medicines.
What is Esodip used for?
Levamlodipine Maleate is a calcium channel blocker. Doctors prescribe it for hypertension, to lower blood pressure, and it can be used alone or together with other antihypertensive agents.
What are the side effects of Esodip?
Common side effects of Levamlodipine Maleate are difficulty in breathing, dizziness, reflex tachycardia, hypotension, abdominal pain and edema. Rare ones are diarrhea, back pain, headache, fatigue and nausea.
Can I take Esodip during pregnancy or while breastfeeding?
There isn't much post-marketing data on amlodipine use in pregnant women, and what exists isn't enough to say whether the medicine carries a risk of major birth defects or miscarriage. For breastfeeding, no adverse effects of amlodipine have been seen in the breastfed infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Esodip?
An overdose of levamlodipine maleate would be expected to cause widespread widening of the blood vessels, with a marked fall in blood pressure and possibly a fast heartbeat as a reflex response. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Esodip?
Keep Levamlodipine Maleate in a cool, dry place, away from light and moisture. And keep all medicines out of reach of children.
Can I take other medicines with Esodip?
Some medicines can interact with Levamlodipine Maleate, for example: Cyclosporine, Amlodipine, Tacrolimus, Simvastatin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
L-Amlo by Navana Pharmaceuticals Ltd. has the same ingredient and strength for ৳9.00 per unit, compared with ৳10.00 for Esodip. Ask your doctor or pharmacist before switching.
Do I need a prescription for Esodip?
Esodip is a prescription (Rx) medicine. Take it as your doctor advises.